Longitudinal associations between monetary value of the diet, DASH diet score and the allostatic load among middle-aged urban adults

Lower cost can lead to poorer-quality diets, potentially worsening metabolic profiles. We explored these pathways among urban adults. Longitudinal data were extracted from 1224-1479 participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. DASH(mean) (Dietary Approaches to Stop Hypertension) score was computed using four 24 h recalls (v1/v2: 2004-2013) linked with a national food price database to estimate monetary value of the diet [MVD(mean)]. Allostatic load (AL) was measured at visits 2 (v2) and 3 (v3) in 2009-2018. Mixed-effects regression and structural equation modeling (SEM) were conducted, linking MVD(mean)/DASH(mean) to AL [v2 and annual change(v3-v2)] and exploring mediating pathways between MVD(mean) and AL(v3) through DASH(mean), stratifying by sex, race and poverty status. MVD(mean) tertiles were linearly associated with contemporaneous DASH(mean), after energy adjustment. In mixed-effects regression models, DASH(mean) was consistently linked to lower AL(v2). DASH(mean) and MVD(mean) were positively associated with higher serum albumin(v2). In SEM, MVD(mean) was linked to AL(v3) through DASH(mean), mainly among Whites and specifically for the cholesterol and Waist-Hip-Ratio AL components. In summary, energy and other covariate-adjusted increase in MVD may have a sizeable impact on DASH which can reduce follow-up AL among urban White middle-aged adults. More studies are needed to replicate findings in comparable samples of urban adults

Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis

While dementia affects 6-10% of persons 65 years or older, industrialized countries have witnessed an alarming rise in obesity. However, obesity\u27s influence on dementia remains poorly understood. The conducted a systematic review and meta-analysis. PUBMED search (1995-2007) resulted in 10 relevant prospective cohort studies of older adults (40-80 years at baseline) with end points being dementia and predictors including adiposity measures, such as body mass index (BMI) and waist circumference (WC). There was a significant U-shaped association between BMI and dementia (P= 0.034), with dementia risk increased for obesity and underweight. Pooled odds ratios (OR) and 95% confidence intervals (CI) for underweight, overweight and obesity compared with normal weight in relation to incident dementia were: 1.36 (1.07, 1.73), 0.88 (0.60, 1.27) and 1.42 (0.93, 2.18) respectively. Pooled ORs and 95% CI for obesity and incident Alzheimer\u27s disease (AD) and vascular dementia were 1.80 (1.00, 3.29) vs. 1.73 (0.47, 6.31) and were stronger in studies with long follow-up (>10 years) and young baseline age

The role of multiple weak lithologies in the deformation of cover units in the northwestern segment of the zagros fold-and-thrust belt

The geometry, kinematics and dynamics of fold-and-thrust belts are strongly influenced by the mechanical behaviour of the basal decollement. However, many fold-and-thrust belts also include mechanically weak lithologies such as evaporites and marls or mudstones at different levels within the shortened stratigraphy. The kinematics and dynamic evolution of these thrust belts are controlled by the mechanical behaviour both of the basal decollement and of the weak units embedded within the overlying stratigraphic succession. In the Zagros fold-and-thrust belt (ZFTB), the shortened sedimentary cover is between 7 and 12 km thick and mechanically weak lithologies compartmentalize the stratigraphic column at shallow and intermediate levels. In this paper, satellite, field and seismic data from the Kurdistan Region of Iraq are used to identify structures of different sizes and surface traces. The observations are used to underline the role of mechanically weak horizons within the Zagros stratigraphy and the decoupling of deformation both laterally and with depth in the belt. The decoupling between shallow and deeper structures observed in seismic profiles from the Kurdistan Region of Iraq is also reported from field observations from the Iranian part of the Zagros fold-and-thrust belt, where folds with different surface traces occur. Decoupling between shallow and deep layers by incompetent lithologies at intermediate depths (e.g. marls, mudstones and evaporites) results in the formation of disharmonic folds. The geometry, size and location of such folds may differ between outcropping and subsurface structures. Decoupling may have a significant impact on hydrocarbon exploration in different parts of the Zagros fold-and-thrust belt due to potential offsets between outcropping and subsurface structures and their associated traps