Notes on research into some aspects of stall-warning devices

The problems of detecting and indicating an approaching stall have been investigated in flight on an “Anson” aircraft. A lower-surface flap near the leading-edge of the wing detects the approaching stall at a speed which depends critically on the length of the flap and on its location, but the margin of warning speed over stalling-speed is reasonably independent of landing-flap position and throttle setting. Continues

The Global Mobilities of Russian Museums: The State Russian Museum Goes to Málaga

Museums are establishing foreign branches and satellite museums abroad, illustrating a growing trend among both public and private museums. Guggenheim, Louvre, Centre Pompidou, The State Hermitage Museum and Victoria and Albert Museum are a few of the cultural institutions that have presence abroad in the form of physical exhibition sites. In addition to creating permanent venues in foreign countries, many museums also cooperate internationally through temporary circulating exhibitions that engage expert exchanges and diplomatic relations. This article frames the discussion about the role of art museums as practitioners and actors of international cultural diplomacy and cultural relations. It delves into the interplay between the state actors and non-state actors that are involved in the museums’ trajectories, further extending the understanding of constituent and influential actors in international relations. In particular, the focus is on the State Russian Museum’s first foreign branch that was opened in Málaga, Spain in March 2015. First, the paper identifies the key actors, who contributed to the project, paying attention to both the state actors and non-state actors. Second, the paper reviews the purpose of establishing the museum in Málaga in the context of the interests of each of the selected actors. The paper concludes with a brief discussion on how the analysis of foreign branches and satellite museums could be deepened and what methodological instruments would be beneficial for further research

Venäjän Venetsian-paviljongin paradoksaalinen valta

Artikkeli käsittelee Venetsian nykytaidebiennaalia, taidemaailman megatapahtumaa. Sen lähtökohtana on huomio megatapahtumien paradoksaalisuudesta. Tarkastelemme Venäjän kansallisen Venetsian-paviljongin paradokseja analysoimalla, miten yksityisen taidesäätiön johtaja ja ”oligarkin vaimo” Stella Kesajeva nousi Venäjän kansallisen Venetsian-paviljonginkomissaariksi kaudelle 2011–2015. Esitämme, että biennaali tarjosi olosuhteet yhteiskunnalliselle ja poliittiselle alkemialle, jossa taloudellista pääomaa on mahdollista muuntaa symboliseksi pääomaksi tai symbolista taloudelliseksi. Venetsian biennaalin paradoksaalisuutta voidaan selittää sillä, että kyseessä on Pierre Bourdieun käsittein heteronominen tila. Yhteiskunnan eri kenttien arvostusperiaatteet risteävät biennaalissa, mikä synnyttää paradokseja. Pohdimme artikkelissa myös nykytaiteen ja Venetsian-paviljongin muutosvoimaa suhteessa Venäjän kleptokratiseen järjestelmään, jossa vauraan bisneseliitin ja valtion suhteet ovat kietoutuneet yhteen sekä varallisuus huomattavan epätasaisesti jakautunutta

Development of a cloud-based Bioinformatics Training Platform

First published online: April 15, 2016The Bioinformatics Training Platform (BTP) has been developed to provide access to the computational infrastructure required to deliver sophisticated hands-on bioinformatics training courses. The BTP is a cloud-based solution that is in active use for delivering next-generation sequencing training to Australian researchers at geographically dispersed locations. The BTP was built to provide an easy, accessible, consistent and cost-effective approach to delivering workshops at host universities and organizations with a high demand for bioinformatics training but lacking the dedicated bioinformatics training suites required. To support broad uptake of the BTP, the platform has been made compatible with multiple cloud infrastructures. The BTP is an open-source and open-access resource. To date, 20 training workshops have been delivered to over 700 trainees at over 10 venues across Australia using the BTP.Jerico Revote, Nathan S. Watson-Haigh, Steve Quenette, Blair Bethwaite, Annette McGrath and Catherine A. Shan

P008 Fracture liaison service management of patients aged 85 and older who sustain fragility fractures: audit and quality improvement

Abstract Background/Aims Osteoporosis is a burdensome disease internationally, that is commonly diagnosed following fragility fracture. In line with national guidance, in 2018 the North Staffordshire Fracture Liaison Service (FLS) changed their management policy of patients aged ≥85 years who sustain fragility fractures. Instead of calling these patients for a dual-energy X-ray absorptiometry (DXA) scan, a letter was sent to the patient’s General Practitioner, advising the empirical commencement of oral bisphosphonates. This audit aimed to evaluate whether the recommendations in this letter were enacted by GPs. Following audit, the text of the letter was changed, and a re-audit conducted to evaluate changes in practice. Methods Patients aged ≥85 years sustaining a fragility fracture between December 2018 and October 2020 were identified from FLS records. Summary Care Records (SCRs) were used to identify whether each patient was receiving a bisphosphonate prescription at time of audit (October 2020). Analysis was descriptive, to report the proportion of patients prescribed a bisphosphonate. Quality improvement methodology informed changes to the standard letter, using GP feedback. Re-audit of fragility fractures occurring between December 2020 and May 2021 was undertaken in July 2021 to assess possible impact. Results 408 eligible patients were identified in the initial audit, of which 79% were female. SCR data was available for 396 patients; median time between fracture and data collection was 9 months. 160 patients (40%) had a bisphosphonate prescribed as an acute or repeat prescription, of which &amp;gt;90% were alendronic acid. Following the first audit cycle, the letter was changed to address barriers to clinical decision-making including advice on relative contraindications and referral. 74 patient SCRs were reviewed in the 2nd audit cycle (85% female) and 38 (51%) were recorded as prescribed a bisphosphonate (median time between fracture and assessment 5-months). Conclusion Rates of bisphosphonate prescribing, in people aged ≥85 following a recommendation letter sent to the GP, have increased from 40% to 51% following quality improvement initiative. Furthermore, the proportion of patients prescribed a bisphosphonate is similar to previous national data in patients post-DXA. This is of interest, particularly given the de-prioritisation of non-communicable diseases during the COVID-19 pandemic, and demonstrates that an intervention which requires little time, can result in changes in practice. Limitations of this work include that the SCR only includes contemporaneous prescribing data so the period of time between drug recommendation and audit was different in 1st and 2nd cycles, meaning that adherence may be expected to be higher in the 2nd cycle, because the period of time between letter and data collection was shorter, and not because of a change in our intervention. Disclosure T. Appleyard: None. K. Bethwaite: None. N. Dale: None. F. Manning: None. Z. Paskins: None. </jats:sec

Low density of CD3+, CD4+ and CD8+ cells is associated with increased risk of relapse in squamous cell cervical cancer

The purpose of this study was to investigate the prognostic value of the primary in situ cellular immune response in cervical squamous cell carcinoma. A study of 102 women treated for stage IB and IIA disease, between 1990 and 2000, was performed. Paraffin-embedded cervical tissue processed at the time of diagnosis was immunostained for CD3+ (T cells), CD4+ (T helper/regulatory T cells) and CD8+ (cytotoxic T cells) cells. Immune cell profile densities were estimated using stereology. Both intra- and peritumoural cell densities were estimated. Using Cox's proportional hazards regression modelling we found an increase in cell density to decrease the risk of relapse for all three cell types. The density of peritumoural CD3+ cells seems to have the strongest potential for predicting relapse. An increase in CD3+ cell density from 795 to 2043 cells per mm2 (25–75 percentile) reduced the hazard ratio to 0.27

Overview of the National Occupational Mortality Surveillance (NOMS) System: Leukemia and Acute Myocardial Infarction Risk by Industry and Occupation in 30 US States 1985–1999, 2003–2004, and 2007

Background Cancer and chronic disease are leading causes of death in the US with an estimated cost of $46 billion. Methods We analyzed 11 million cause-specific deaths of US workers age 18–64 years in 30 states during 1985–1999, 2003–2004, and 2007 by occupation, industry, race, gender, and Hispanic origin. Results The highest significantly elevated proportionate leukemia mortality was observed in engineers, protective service, and advertising sales manager occupations and in banks/savings &loans/credit agencies, public safety, and public administration industries. The highest significantly elevated smoking-adjusted acute myocardial infarction mortality was noted in industrial and refractory machinery mechanics, farmers, mining machine operators, and agricultural worker occupations; and wholesale farm supplies, agricultural chemical, synthetic rubber, and agricultural crop industries. Conclusions Significantly elevated risks for acute myocardial infarction and leukemia were observed across several occupations and industries that confirm existing reports and add new information