79 research outputs found
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study
C-reactive protein (CRP) is a circulating biomarker indicative of systemic inflammation. We aimed to evaluate genetic associations with CRP levels among non-European-ancestry populations through discovery, fine-mapping and conditional analyses. A total of 30 503 non-European-ancestry participants from 6 studies participating in the Population Architecture using Genomics and Epidemiology study had serum high-sensitivity CRP measurements and ~200 000 single nucleotide polymorphisms (SNPs) genotyped on the Metabochip. We evaluated the association between each SNP and log-transformed CRP levels using multivariate linear regression, with additive genetic models adjusted for age, sex, the first four principal components of genetic ancestry, and study-specific factors. Differential linkage disequilibrium patterns between race/ ethnicity groups were used to fine-map regions associated with CRP levels. Conditional analyses evaluated for multiple independent signals within genetic regions. One hundred and sixty-three unique variants in 12 loci in overall or race/ ethnicity-stratified Metabochip-wide scans reached a Bonferroni-corrected P-value<2.5E-7. Three loci have no (HACL1, OLFML2B) or only limited (PLA2G6) previous associations with CRP levels. Six loci had different top hits in race/ethnicityspecific versus overall analyses. Fine-mapping refined the signal in six loci, particularly in HNF1A. Conditional analyses provided evidence for secondary signals in LEPR, IL1RN and HNF1A, and for multiple independent signals in CRP and APOE. We identified novel variants and loci associated with CRP levels, generalized known CRP associations to a multiethnic study population, refined association signals at several loci and found evidence for multiple independent signals at several well-known loci. This study demonstrates the benefit of conducting inclusive genetic association studies in large multiethnic populations
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Report of biological investigations at the Los Medanos Waste Isolation Pilot Plant (WIPP) area of New Mexico during FY 1978
The US Department of Energy is considering the construction of a Waste Isolation Pilot Plant (WIPP) in Eddy County, NM. This location is approximately 40 km east of Carlsbad, NM. Biological studies during FY 1978 were concentrated within a 5-mi radius of drill hole ERDA 9. Additional study areas have been established at other sites in the vicinity, e.g., the Gnome site, the salt lakes and several stations along the Pecos River southward from Carlsbad, NM, to the dam at Red Bluff Reservoir in Texas. The precise locations of all study areas are presented and their biology discussed
[O III] emission line as a tracer of star-forming galaxies at high redshifts: comparison between Hα and [O III] emitters at z=2.23 in HiZELS
We investigate the properties of z = 2.23 Hα and [O III] λ5007 emitters using the narrow-band-selected samples obtained from the High-z Emission Line Survey. We construct two samples of the Hα and [O III] emitters and compare their integrated physical properties. We find that the distribution of stellar masses, dust extinction, star formation rates (SFRs), and specific SFRs (sSFRs) is not statistically different between the two samples. When we separate the full galaxy sample into three subsamples according to the detections of the Hα and/or [O III] emission lines, most of the sources detected with both Hα and [O III] show log(sSFRUV) ≳ −9.5. The comparison of the three subsamples suggests that sources with strong [O III] line emission tend to have the highest star-forming activity out all galaxies that we study. We argue that the [O III] emission line can be used as a tracer of star-forming galaxies at high redshift, and that it is especially useful to investigate star-forming galaxies at z > 3, for which Hα emission is no longer observable from the ground
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