7,785 research outputs found
Hybridization gap and anisotropic far-infrared optical conductivity of URu2Si2
We performed far-infrared optical spectroscopy measurements on the heavy
fermion compound URu 2 Si 2 as a function of temperature. The light's
electric-field was applied along the a-axis or the c-axis of the tetragonal
structure. We show that in addition to a pronounced anisotropy, the optical
conductivity exhibits for both axis a partial suppression of spectral weight
around 12 meV and below 30 K. We attribute these observations to a change in
the bandstructure below 30 K. However, since these changes have no noticeable
impact on the entropy nor on the DC transport properties, we suggest that this
is a crossover phenomenon rather than a thermodynamic phase transition.Comment: To be published in Physical Review
bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish.
Hematopoiesis maintains the entire blood system, and dysregulation of this process can lead to malignancies (leukemia), immunodeficiencies or red blood cell diseases (anemia, polycythemia vera). We took advantage of the zebrafish model that shares most of the genetic program involved in hematopoiesis with mammals to characterize a new gene of unknown function, si:ch73-299h12.2, which is expressed in the erythroid lineage during primitive, definitive and adult hematopoiesis. This gene, required during primitive and definitive erythropoiesis, encodes a C2H2 zinc-finger protein that inhibits BMP signaling. We therefore named this gene blood-inducing factor 1 and BMP inhibitory factor 1 (bif1). We identified a bif1 ortholog in Sinocyclocheilus rhinocerous, another fish, and in the mouse genome. Both genes also inhibit BMP signaling when overexpressed in zebrafish. In conclusion, we have deorphanized a new zebrafish gene of unknown function: bif1 codes for a zinc-finger protein that inhibits BMP signaling and also regulates primitive erythropoiesis and definitive hematopoiesis
Hydraulic interactions between fractures and bedding planes in a carbonate aquifer studied by means of experimentally induced water-table fluctuations (Coaraze experimental site, southeastern France)
International audienceIn aquifers with variable permeability, the water exchanges between high and low permeability regions are controlled by the hydraulic head gradient. Past studies have addressed this problem mainly considering steadystate hydraulic conditions. To study such exchanges during water-table fluctuations, a spring was equipped with a water-gate that creates 10-meter artificial fluctuations of the water table. The water exchanges are discussed with respect to hydrochemical and pressure measurements in the groundwater. With successive water-table fluctuations the mineralization and pH decrease, but the bicarbonate content increases in response to carbon dioxide dissolution . At this scale of single fractures and surroundings, the hydrochemistry allows water flows from low or high permeability discontinuities to be discriminated. During hydraulic head fluctuations, the waters from low and high permeability discontinuities become mixed. During water-table rise, the low-permeability matrix contributed to the refilling of the permeable faults and to the mixing of the waters. Dynamic flows in the opposite direction to the hydraulic gradient can expel mineralized water, pushing it towards permeable discontinuities. This mechanism could be the cause of the peak in the mineralisation recorded in some karst springs at the start of flood events
A New Tool Preliminary Assessment on Temporal-Comorbidity Adjusted Risk of Emergency Readmission (T-CARER)
Patients’ comorbidities, operations and complications can be associated with reduced long-term survival probability and increased healthcare utilisation. The aim of this research was to produce an adjusted case-mix model of comorbidity risk and develop a user-friendly toolkit to encourage public adaptation and incremental development.It has been shown in healthcare research that demographics, temporal dimensions, length-of-stay and time between admissions, can noticeably improve the statistical measures related to comorbidities. The proposed model incorporates temporal aspects, medical procedures, demographics, and admission details, as well as diagnoses.The research resulted in the development of Temporal-Comorbidity Adjusted Risk of Emergency Readmission (T-CARER) model using routinely collected hospital data
Test engineering education in Europe: the EuNICE-Test project
The paper deals with a European experience of education in industrial test of ICs and SoCs using remote testing facilities. The project addresses the problem of the shortage in microelectronics engineers aware with the new challenge of testing mixed-signal SoCs far multimedia/telecom market. It aims at providing test training facilities at a European scale in both initial and continuing education contexts. This is done by allowing the academic and industrial partners of the consortium to train engineers using the common test resources center (CRTC) hosted by LIRMM (Laboratoire d'Informatique, de Robotique et de Microelectronique de Montpellier, France). CRTC test tools include up-to-date/high-tech testers that are fully representative of real industrial testers as used on production testfloors. At the end of the project, it is aimed at reaching a cruising speed of about 16 trainees per year per center. Each trainee will have attend at least one one-week training using the remote test facilities of CRTC
Mesoscopic rings with Spin-Orbit interactions
A didactic description of charge and spin equilibrium currents on mesoscopic
rings in the presence of Spin-Orbit interaction is presented. Emphasis is made
on the non trivial construction of the correct Hamiltonian in polar
coordinates, the calculation of eigenvalues and eigenfunctions and the
symmetries of the ground state properties. Spin currents are derived following
an intuitive definition and then a more thorough derivation is built upon the
canonical Lagrangian formulation that emphasizes the SU(2) gauge structure of
the transport problem of spin 1/2 fermions in spin-orbit active media. The
quantization conditions that follow from the constraint of single-valued Pauli
spinors are also discussed. The targeted students are those of a graduate
Condensed Matter Physics course
Diffusion over a saddle with a Langevin equation
The diffusion problem over a saddle is studied using a multi-dimensional
Langevin equation. An analytical solution is derived for a quadratic potential
and the probability to pass over the barrier deduced. A very simple solution is
given for the one dimension problem and a general scheme is shown for higher
dimensions.Comment: 13 pages, use revTeX, to appear in Phys. Rev. E6
Dynamic ferromagnetic proximity effect in photoexcited semiconductors
The spin dynamics of photoexcited carriers in semiconductors in contact with
a ferromagnet is treated theoretically and compared with time-dependent Faraday
rotation experiments. The long time response of the system is found to be
governed by the first tens of picoseconds in which the excited plasma interacts
strongly with the intrinsic interface between semiconductor and ferromagnet in
spite of the existence of a Schottky barrier in equilibrium
Potentials for hyper-Kahler metrics with torsion
We prove that locally any hyper-K\"ahler metric with torsion admits an HKT
potential.Comment: 9 page
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates
During development, hematopoietic stem cells (HSCs) are produced from the hemogenic endothelium and will expand in a transient hematopoietic niche. Prostaglandin E2 (PGE2) is essential during vertebrate development and HSC specification, but its precise source in the embryo remains elusive. Here, we show that in the zebrafish embryo, PGE2 synthesis genes are expressed by distinct stromal cell populations, myeloid (neutrophils, macrophages), and endothelial cells of the caudal hematopoietic tissue. Ablation of myeloid cells, which produce the PGE2 precursor prostaglandin H2 (PGH2), results in loss of HSCs in the caudal hematopoietic tissue, which could be rescued by exogeneous PGE2 or PGH2 supplementation. Endothelial cells contribute by expressing the PGH2 import transporter slco2b1 and ptges3, the enzyme converting PGH2 into PGE2. Of note, differential niche cell expression of PGE2 biosynthesis enzymes is also observed in the mouse fetal liver. Taken altogether, our data suggest that the triad composed of neutrophils, macrophages, and endothelial cells sequentially and synergistically contributes to blood stem cell expansion during vertebrate development
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