319 research outputs found
Effects of intermediate scales on renormalization group running of fermion observables in an SO(10) model
In the context of non-supersymmetric SO(10) models, we analyze the
renormalization group equations for the fermions (including neutrinos) from the
GUT energy scale down to the electroweak energy scale, explicitly taking into
account the effects of an intermediate energy scale induced by a Pati--Salam
gauge group. To determine the renormalization group running, we use a numerical
minimization procedure based on a nested sampling algorithm that randomly
generates the values of 19 model parameters at the GUT scale, evolves them, and
finally constructs the values of the physical observables and compares them to
the existing experimental data at the electroweak scale. We show that the
evolved fermion masses and mixings present sizable deviations from the values
obtained without including the effects of the intermediate scale.Comment: Comments: 20 pages, 3 figures. Final version published in JHE
Supersymmetric 3-branes on smooth ALE manifolds with flux
We construct a new family of classical BPS solutions of type IIB supergravity
describing 3-branes transverse to a 6-dimensional space with topology R^2*ALE.
They are characterized by a non-trivial flux of the supergravity 2-forms
through the homology 2-cycles of a generic smooth ALE manifold. Our solutions
have two Killing spinors and thus preserve N=2 supersymmetry. They are
expressed in terms of a quasi harmonic function H (the ``warp factor''), whose
properties we study in the case of the simplest ALE, namely the Eguchi-Hanson
manifold. The equation for H is identified as an instance of the confluent Heun
equation. We write explicit power series solutions and solve the recurrence
relation for the coefficients, discussing also the relevant asymptotic
expansions. While, as in all such N=2 solutions, supergravity breaks down near
the brane, the smoothing out of the vacuum geometry has the effect that the
warp factor is regular in a region near the cycle. We interpret the behavior of
the warp factor as describing a three-brane charge ``smeared'' over the cycle
and consider the asymptotic form of the geometry in that region, showing that
conformal invariance is broken even when the complex type IIB 3-form field
strength is assumed to vanish. We conclude with a discussion of the basic
features of the gauge theory dual.Comment: latex, 36 pages (26 + appendix). Some statements on the gauge dual
made more precise. Final version to appear on NP
Strings in AdS_4 x CP^3: finite size spectrum vs. Bethe Ansatz
We compute the first curvature corrections to the spectrum of light-cone
gauge type IIA string theory that arise in the expansion of about a plane-wave limit. The resulting spectrum is shown to
match precisely, both in magnitude and degeneration that of the corresponding
solutions of the all-loop Gromov--Vieira Bethe Ansatz. The one-loop dispersion
relation correction is calculated for all the single oscillator states of the
theory, with the level matching condition lifted. It is shown to have all
logarithmic divergences cancelled and to leave only a finite exponentially
suppressed contribution, as shown earlier for light bosons. We argue that there
is no ambiguity in the choice of the regularization for the self-energy sum,
since the regularization applied is the only one preserving unitarity.
Interaction matrices in the full degenerate two-oscillator sector are
calculated and the spectrum of all two light magnon oscillators is completely
determined. The same finite-size corrections, at the order 1/J, where is
the length of the chain, in the two-magnon sector are calculated from the all
loop Bethe Ansatz. The corrections obtained by the two completely different
methods coincide up to the fourth order in . We
conjecture that the equivalence extends to all orders in and to
higher orders in 1/J.Comment: 32 pages. Published version; journal reference adde
The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect
This is the final version. Available from American Society for Microbiology via the DOI in this record. Aspergillus fumigatus is an opportunistic fungal pathogen that causes
invasive aspergillosis (IA), a life-threatening disease in immunocompromised humans.
The echinocandin caspofungin, adopted as a second-line therapy in combating IA, is
a -1,3-glucan synthase inhibitor, which, when used in high concentrations, reverts
the anticipated A. fumigatus growth inhibition, a phenomenon called the “caspofungin
paradoxical effect” (CPE). The CPE has been widely associated with increased chitin
content in the cell wall due to a compensatory upregulation of chitin synthaseencoding
genes. Here, we demonstrate that the CPE is dependent on the cell wall
integrity (CWI) mitogen-activated protein kinase MpkAMPK1 and its associated transcription
factor (TF) RlmARLM1, which regulate chitin synthase gene expression in response
to different concentrations of caspofungin. Furthermore, the calcium- and
calcineurin-dependent TF CrzA binds to and regulates the expression of specific chitin
synthase genes during the CPE. These results suggest that the regulation of cell
wall biosynthetic genes occurs by several cellular signaling pathways. In addition,
CrzA is also involved in cell wall organization in the absence of caspofungin. Differences
in the CPE were also observed between two A. fumigatus clinical isolates,
which led to the identification of a novel basic leucine zipper TF, termed ZipD. This
TF functions in the calcium-calcineurin pathway and is involved in the regulation of
cell wall biosynthesis genes. This study therefore unraveled additional mechanisms
and novel factors governing the CPE response, which ultimately could aid in developing
more effective antifungal therapies.CNPqFAPES
A realistic pattern of fermion masses from a five-dimensional SO(10) model
We provide a unified description of fermion masses and mixing angles in the
framework of a supersymmetric grand unified SO(10) model with anarchic Yukawa
couplings of order unity. The space-time is five dimensional and the extra flat
spatial dimension is compactified on the orbifold ,
leading to Pati-Salam gauge symmetry on the boundary where Yukawa interactions
are localised. The gauge symmetry breaking is completed by means of a rather
economic scalar sector, avoiding the doublet-triplet splitting problem. The
matter fields live in the bulk and their massless modes get exponential
profiles, which naturally explain the mass hierarchy of the different fermion
generations. Quarks and leptons properties are naturally reproduced by a
mechanism, first proposed by Kitano and Li, that lifts the SO(10) degeneracy of
bulk masses in terms of a single parameter. The model provides a realistic
pattern of fermion masses and mixing angles for large values of . It
favours normally ordered neutrino mass spectrum with the lightest neutrino mass
below 0.01 eV and no preference for leptonic CP violating phases. The right
handed neutrino mass spectrum is very hierarchical and does not allow for
thermal leptogenesis. We analyse several variants of the basic framework and
find that the results concerning the fermion spectrum are remarkably stable.Comment: 30 pages, 7 figures, 4 table
Neutrino masses from new generations
We reconsider the possibility that Majorana masses for the three known
neutrinos are generated radiatively by the presence of a fourth generation and
one right-handed neutrino with Yukawa couplings and a Majorana mass term. We
find that the observed light neutrino mass hierarchy is not compatible with low
energy universality bounds in this minimal scenario, but all present data can
be accommodated with five generations and two right-handed neutrinos. Within
this framework, we explore the parameter space regions which are currently
allowed and could lead to observable effects in neutrinoless double beta decay,
conversion in nuclei and experiments. We
also discuss the detection prospects at LHC.Comment: 28 pages, 4 figures. Version to be published. Some typos corrected.
Improved figures 3 and
Lepton flavour violation in the MSSM
We derive new constraints on the quantities delta_{XY}^{ij}, X,Y=L,R, which
parametrise the flavour-off-diagonal terms of the charged slepton mass matrix
in the MSSM. Considering mass and anomalous magnetic moment of the electron we
obtain the bound |delta^{13}_{LL} delta^{13}_{RR}|<0.1 for tan beta=50, which
involves the poorly constrained element delta^{13}_{RR}. We improve the
predictions for the decays tau -> mu gamma, tau -> e gamma and mu -> e gamma by
including two-loop corrections which are enhanced if tan beta is large. The
finite renormalisation of the PMNS matrix from soft SUSY-breaking terms is
derived and applied to the charged-Higgs-lepton vertex. We find that the
experimental bound on BR(tau -> e gamma) severely limits the size of the MSSM
loop correction to the PMNS element U_{e3}, which is important for the proper
interpretation of a future U_{e3} measurement. Subsequently we confront our new
values for delta^{ij}_{LL} with a GUT analysis. Further, we include the effects
of dimension-5 Yukawa terms, which are needed to fix the Yukawa unification of
the first two generations. If universal supersymmetry breaking occurs above the
GUT scale, we find the flavour structure of the dimension-5 Yukawa couplings
tightly constrained by mu -> e gamma.Comment: 37 pages, 15 figures; typo in Equation (35) and (49) correcte
Flavor Physics in an SO(10) Grand Unified Model
In supersymmetric grand-unified models, the lepton mixing matrix can possibly
affect flavor-changing transitions in the quark sector. We present a detailed
analysis of a model proposed by Chang, Masiero and Murayama, in which the
near-maximal atmospheric neutrino mixing angle governs large new b -> s
transitions. Relating the supersymmetric low-energy parameters to seven new
parameters of this SO(10) GUT model, we perform a correlated study of several
flavor-changing neutral current (FCNC) processes. We find the current bound on
B(tau -> mu gamma) more constraining than B(B -> X_s gamma). The LEP limit on
the lightest Higgs boson mass implies an important lower bound on tan beta,
which in turn limits the size of the new FCNC transitions. Remarkably, the
combined analysis does not rule out large effects in B_s-B_s-bar mixing and we
can easily accomodate the large CP phase in the B_s-B_s-bar system which has
recently been inferred from a global analysis of CDF and DO data. The model
predicts a particle spectrum which is different from the popular Constrained
Minimal Supersymmetric Standard Model (CMSSM). B(tau -> mu gamma) enforces
heavy masses, typically above 1 TeV, for the sfermions of the degenerate first
two generations. However, the ratio of the third-generation and
first-generation sfermion masses is smaller than in the CMSSM and a (dominantly
right-handed) stop with mass below 500 GeV is possible.Comment: 44 pages, 5 figures. Footnote and references added, minor changes,
Fig. 2 corrected; journal versio
Recommended from our members
All-sky search for short gravitational-wave bursts in the second Advanced LIGO and Advanced Virgo run
We present the results of a search for short-duration gravitational-wave transients in the data from the second observing run of Advanced LIGO and Advanced Virgo. We search for gravitational-wave transients with a duration of milliseconds to approximately one second in the 32-4096 Hz frequency band with minimal assumptions about the signal properties, thus targeting a wide variety of sources. We also perform a matched-filter search for gravitational-wave transients from cosmic string cusps for which the waveform is well modeled. The unmodeled search detected gravitational waves from several binary black hole mergers which have been identified by previous analyses. No other significant events have been found by either the unmodeled search or the cosmic string search. We thus present the search sensitivities for a variety of signal waveforms and report upper limits on the source rate density as a function of the characteristic frequency of the signal. These upper limits are a factor of 3 lower than the first observing run, with a 50% detection probability for gravitational-wave emissions with energies of ∼10-9 Mc2 at 153 Hz. For the search dedicated to cosmic string cusps we consider several loop distribution models, and present updated constraints from the same search done in the first observing run
- …