The Atacama Cosmology Telescope: Physical Properties and Purity of a Galaxy Cluster Sample Selected via the Sunyaev-Zel'dovich Effect

We present optical and X-ray properties for the first confirmed galaxy cluster sample selected by the Sunyaev-Zel'dovich Effect from 148 GHz maps over 455 square degrees of sky made with the Atacama Cosmology Telescope. These maps, coupled with multi-band imaging on 4-meter-class optical telescopes, have yielded a sample of 23 galaxy clusters with redshifts between 0.118 and 1.066. Of these 23 clusters, 10 are newly discovered. The selection of this sample is approximately mass limited and essentially independent of redshift. We provide optical positions, images, redshifts and X-ray fluxes and luminosities for the full sample, and X-ray temperatures of an important subset. The mass limit of the full sample is around 8e14 Msun, with a number distribution that peaks around a redshift of 0.4. For the 10 highest significance SZE-selected cluster candidates, all of which are optically confirmed, the mass threshold is 1e15 Msun and the redshift range is 0.167 to 1.066. Archival observations from Chandra, XMM-Newton, and ROSAT provide X-ray luminosities and temperatures that are broadly consistent with this mass threshold. Our optical follow-up procedure also allowed us to assess the purity of the ACT cluster sample. Eighty (one hundred) percent of the 148 GHz candidates with signal-to-noise ratios greater than 5.1 (5.7) are confirmed as massive clusters. The reported sample represents one of the largest SZE-selected sample of massive clusters over all redshifts within a cosmologically-significant survey volume, which will enable cosmological studies as well as future studies on the evolution, morphology, and stellar populations in the most massive clusters in the Universe.Comment: 20 pages, 15 figures, 6 tables. Accepted for publication in ApJ. Higher resolution figures available at: http://peumo.rutgers.edu/~felipe/e-prints

An iconic language for the graphical representation of medical concepts

<p>Abstract</p> <p>Background</p> <p>Many medication errors are encountered in drug prescriptions, which would not occur if practitioners could remember the drug properties. They can refer to drug monographs to find these properties, however drug monographs are long and tedious to read during consultation. We propose a two-step approach for facilitating access to drug monographs. The first step, presented here, is the design of a graphical language, called VCM.</p> <p>Methods</p> <p>The VCM graphical language was designed using a small number of graphical primitives and combinatory rules. VCM was evaluated over 11 volunteer general practitioners to assess if the language is easy to learn, to understand and to use. Evaluators were asked to register their VCM training time, to indicate the meaning of VCM icons and sentences, and to answer clinical questions related to randomly generated drug monograph-like documents, supplied in text or VCM format.</p> <p>Results</p> <p>VCM can represent the various signs, diseases, physiological states, life habits, drugs and tests described in drug monographs. Grammatical rules make it possible to generate many icons by combining a small number of primitives and reusing simple icons to build more complex ones. Icons can be organized into simple sentences to express drug recommendations. Evaluation showed that VCM was learnt in 2 to 7 hours, that physicians understood 89% of the tested VCM icons, and that they answered correctly to 94% of questions using VCM (versus 88% using text, <it>p </it>= 0.003) and 1.8 times faster (<it>p </it>< 0.001).</p> <p>Conclusion</p> <p>VCM can be learnt in a few hours and appears to be easy to read. It can now be used in a second step: the design of graphical interfaces facilitating access to drug monographs. It could also be used for broader applications, including the design of interfaces for consulting other types of medical document or medical data, or, very simply, to enrich medical texts.</p

La PIPAC (Pressurised IntraPeritoneal Aerosol Chemotherapy) en traitement des carcinoses péritonéales d’origine digestive : résultats

Médecine. Chirurgie viscérale et digestiventroduction : la PIPAC (Pressurized IntraPeritonal Aerosol Chemothérapy) est une technique récente, qui entre dans l’arsenal thérapeutique des patients atteints de carcinose péritonéale (CP). L’objectif de ce travail est d’évaluer, dans un premier temps, la réponse tumorale en termes de régression histologique et dans un deuxième temps, d’étudier la survie et la qualité de vie. Méthode : nous avons inclus prospectivement tous les patients atteints d’une CP d’origine digestive ou de tumeur primitive du péritoine, non éligibles à une chirurgie de cytoréduction complète et traités par PIPAC. Nous avons recueilli les données démographiques, pathologiques, chirurgicales et de survie. Au cours de chaque intervention, des biopsies ont été réalisées pour effectuer un examen anatomopathologique et une analyse du score de régression histologique (PRGS). Un questionnaire (SF36 et QLQ30) a été complété par les patients, lors de chaque hospitalisation.Résultats : de janvier 2018 à mai 2020, 52 patients ont été inclus. Nous avons comptabilisé 184 procédures de PIPAC, soit une moyenne de 3,5 procédures par patient. L’inaccessibilité à la cavité abdominale, a concerné seulement 9 patients. Les complications ont comporté 1 bronchospasme allergique (0,5%), une péritonite chez 2 patients (1%). Il n’y a pas eu de décès. Le score PRGS était en régression pour 30% des patients et stabilisé pour 55% des patients. Deux patients (3,7%) ont pu bénéficier d’une chirurgie de cytoréduction complète, après des cycles de PIPAC. Nous avons pu noter, une amélioration de la qualité de vie, en analysant le questionnaire SF36, au fur et à mesure des procédures. Conclusion : la PIPAC est une technique sûre, pouvant entrainer une régression tumorale histologique, tout en maintenant une qualité de vie satisfaisante.Introduction : PIPAC (Pressurized IntraPeritonal Aerosol Chemothérapy) is a novel approach for treating patient with peritoneal carcinomatosis. The aim of this study is to access first tumor respons in term of histological regression et second the survey and the quality of life. Method : we included prospectively all patients with visceral peritonal carcinomatosis or primitiv peritoneal tumor, not eligible for a complete cytoreduction surgery and treted by PIPAC. We collected the demographic, pathologic, surgical and survey data. During each procedure, biopsie were realised to perform an histopathological examination and analysed the Peritoneal Regression Score (PRGS). A quality of life questionnary (SF 36 ans QLQ 30) was completed by patient in each hospitalization. Result : from January 2018 to May 2020, 52 patients were included. We recorded 184 PIPAC (average 3.5 procedure by patient). the no access rate to the abdominal cavity concerned only 9 patients. Complications were included 1 allergic bronchospasme (0.5%), 2 peritonitis (1%). There wasn't death. The PRGS score was in regression in 30% patient ans stabilised in 55% of patients. Two patients (3.7%) received complete cytoreduction surgery after PIPAC procedure. We noticed an improvement quality of life to analyses SF 36 questionnary during PIPAC. Conclusion : PIPAC is a strong technique, with histopatological tumoral regression while maintaining sufficient quality of life in case of peritoneal seading from digestive of gynecologic origi

Eugénie-les-Bains. Traitement de l'entérocolite muco-membraneuse par ses eaux sulfatées calciques

Thèse : Médecine : Université de Bordeaux : 1911N° d'ordre : 8

Analyse diallele du rendement graines par hectare et du poids de 1000 graines chez le soja (Glycine max (l.) merrill

Une analyse diallèle complète selon les méthodes de Griffing et Hayman sur le rendement en graines (kg/ha) et le poids des mille graines (g) de six variétés de soja (Glycine max (L.) Merrill) a été menée à Kamboinsé au Burkina Faso en 2009 et 2010. L’objectif de l’étude était d’analyser le potentiel génétique du matériel mis en compétition et de déterminer les mécanismes génétiques de transmission de ces deux caractères chez des parents à leurs descendances.L’analyse de variance associée aux aptitudes générales et spécifiques à la combinaison (AGC, ASC) et aux effets réciproques (ERC) montre que des effets génétiques de type additif sont à l’origine de la variabilité génétique totale pour les caractères étudiés.Ce travail a permis l’étude de l’hérédité quantitative des deux caractères à améliorer et l’estimation d’un certain nombre de leurs paramètres dont l’héritabilité.Mots clés: Soja, diallèle, rendement graines, poids de mille graines, héritabilitéEnglish Title: Diallel analysis of grain yield and thousand seed weight of soyabean (Glycine max (l.) merrill)English AbstractA complete diallel analysis of grain yield and thousand seeds weight of six soybean varieties were conducted according to Griffing and Hayman methods for diallel analysis at Kamboinsé in Burkina Faso in 2009 and 2010. The objective of the study was to analyse the genetic potential of material sep up in competition and to determine how these characters of parents are transmitted to their descendants. The analysis of variance for the general and specific combining abilities (GCA, SCA) and the reciprocal effects suggested that the part of the genetic variability due to the studied characters was under additive gene control. This work allows study of the quantitative inheritance of the two characters to be improved and estimation of a number of their parameters such as heritability.Keywords: Diallel, soyabean, grain yield, 1000 seeds weight, heritabilit

Quantification of Bound CO2 in various carbonated

CO2STO2019, International Workshop CO2 storage in concrete , Champs-sur-Marne, FRANCE, 24-/06/2019 - 25/06/2019For economic and ecological reasons, supplementary cementitious materials (SCM) are increasingly used in concrete. Although having a lot of advantages, these concretes have different cement matrices and do not have the same evolution as they are carbonated. In this paper, comparison between various carbonated cement pastes with/without SCM (slag, fly ash and metakaolin), has been investigated. Samples are carbonated in accelerated conditions (1.5 % CO2 , RH 65% and T=20°C) until constant mass but in order to be relatively close to the natural conditions and to simulate a carbonation process in the long term. The microstructure was characterized not only by usual techniques such as XRD and TGA-DTA, but also by 29Si and 27Al NMR spectroscopy. The use of a combination of techniques for microstructural Characterization allows to quantify the proportion of each cementitious phase and to determine how much there are carbonated in comparison to reference cement pastes.This quantification shows the evolution of the carbonated cementitious matrix as a function of the binder content. In addition, the results show that the quantity of bound CO2 is not just dependent of portlandite amount. All phases with calcium participate to the fixation of CO2. However, all these phases are not completely carbonated. Bound CO2 is almost only CaCO3. Four CaCO3 polymorphs are detected : calcite, vaterite, aragonite and amorphous

Quantification of Bound CO2 in various carbonated

CO2STO2019, International Workshop CO2 storage in concrete , Champs-sur-Marne, FRANCE, 24-/06/2019 - 25/06/2019For economic and ecological reasons, supplementary cementitious materials (SCM) are increasingly used in concrete. Although having a lot of advantages, these concretes have different cement matrices and do not have the same evolution as they are carbonated. In this paper, comparison between various carbonated cement pastes with/without SCM (slag, fly ash and metakaolin), has been investigated. Samples are carbonated in accelerated conditions (1.5 % CO2 , RH 65% and T=20°C) until constant mass but in order to be relatively close to the natural conditions and to simulate a carbonation process in the long term. The microstructure was characterized not only by usual techniques such as XRD and TGA-DTA, but also by 29Si and 27Al NMR spectroscopy. The use of a combination of techniques for microstructural Characterization allows to quantify the proportion of each cementitious phase and to determine how much there are carbonated in comparison to reference cement pastes.This quantification shows the evolution of the carbonated cementitious matrix as a function of the binder content. In addition, the results show that the quantity of bound CO2 is not just dependent of portlandite amount. All phases with calcium participate to the fixation of CO2. However, all these phases are not completely carbonated. Bound CO2 is almost only CaCO3. Four CaCO3 polymorphs are detected : calcite, vaterite, aragonite and amorphous

Outcomes of Simultaneous Resection of Small Bowel Neuroendocrine Tumors with Synchronous Liver Metastases

International audienceBackgroundThis study evaluated the short- and long-term outcomes of synchronous resection of liver metastases (LM) from small bowel neuroendocrine tumors (SB-NET).MethodsA retrospective review of patients undergoing resection for LMs from SB-NETs from January 1997 and December 2018 was performed.ResultsThere were 44 patients with synchronous SB-NET and LMs. Perioperative and 90-day mortality values were zero, and the morbidity rate was 27%. The median overall survival (OS) was 128.4 months (CI 95% 74.0–161.5 months) with 1-, 3-, 5-, and 10-year survival rates of 100%, 83%, 79%, and 60%, respectively. Not achieving surgical treatment for LM was the unique independent factor for survival (HR 6.50; CI 95% 1.54–27.28; p = 0.01) in patients with unresected LMs having OS and 10-year survival rates (42 months, 33%) versus patients undergoing liver resection (152 months, 66%)(p = 0.0008). The recurrence rate was 81.8% and associated with longer OS and 5-year survival rates when limited to the liver [223 months (61%) vs 94 months (87%)].ConclusionsSimultaneous resection of SB-NETs with synchronous LMs was safe and associated with considerable long-term survival even in the presence of bilobar disease. However, recurrence after resection was common (81%) but associated with longer survival rates when limited to the liver

Limitation of High Water Levels in Bays and Estuaries During Storm Flood Events

International audienceThis study, which involves process-based numerical models validated with reference to tide gauge measurements, tends to specify in what extent the flooding behind the coastline may limit the water levels reached during exceptional events

Brief report of Anti-PD1 in HIV setting: relevant and breaking results in first-line Non Small Cell Lung Cancer therapy

International audienceIn the recent past, we observed an increased risk of cancer in the HIV population due to the development of antiretroviral therapies that decreased mortality caused by HIV-specific infections. This particularly fragile population is frequently excluded from clinical trials, and up-to-date recommendations for these patients are lacking. Only few cases of HIV patients suffering from cancer and undergoing first-line immunotherapy have been reported so far. Here we report the largest known study of HIV patients with non-small cell lung cancer (NSCLC) (5 patients) undergoing first-line immunotherapy by pembrolizumab, following CANCERVIH group selection. Our results are consistent with previous case reports concerning safety of immunotherapy in HIV patients, showing no severe or fatal toxicity, opportunistic infections, or immune reconstitution inflammatory syndrome (IRIS). Moreover, pembrolizumab did not seem to modify HIV viral parameters. We also assessed effectiveness of immunotherapy in these HIV-immunosuppressed patients: the average survival was 9.8 months, with three patients showing rapid progression and two partial response. However, as well as safety and drug-to-drug interactions, the effectiveness of first-line immunotherapy in people living with HIV (PLWHIV) needs to be supported by larger studies