1,079 research outputs found
Odkrycie i zastosowanie pegwisomantu: antagonisty hormonu wzrostu
Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation,
and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions
where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel
drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along
with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional
properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective
GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.
(Pol J Endocrinol 2007; 58 (4): 322-329)Hormon wzrostu (GH, growth hormone) uczestniczy w wielu fizjologicznych procesach dotyczących wzrastania, różnicowania
i metabolizmu. Leczenie rekombinowanym ludzkim GH jest akceptowane w wielu schorzeniach wiążących się
z całkowitym brakiem lub zmniejszeniem działania GH. Wynika stąd znaczne zainteresowanie rozwojem nowych leków
mogących modyfikować czynność GH. Dopiero niedawno wyjaśniono dokładną strukturę GH i jego interakcje z receptorem.
W niniejszej pracy autorzy podsumowują wiedzę dotyczącą podstawowej budowy GH, jego receptora i interakcji
między nimi. Ponadto, omówiono odkrycie i rozwój skutecznego antagonisty receptora GH, pegvisomantu i przedstawiono
potencjalne możliwości zastosowania terapeutycznego tego leku
Numerical model for granular compaction under vertical tapping
A simple numerical model is used to simulate the effect of vertical taps on a
packing of monodisperse hard spheres. Our results are in agreement with an
experimantal work done in Chicago and with other previous models, especially
concerning the dynamics of the compaction, the influence of the excitation
strength on the compaction efficiency, and some ageing effects. The principal
asset of the model is that it allows a local analysis of the packings. Vertical
and transverse density profiles are used as well as size and volume
distributions of the pores. An interesting result concerns the appearance of a
vertical gradient in the density profiles during compaction. Furthermore, the
volume distribution of the pores suggests that the smallest pores, ranging in
size between a tetrahedral and an octahedral site, are not strongly affected by
the tapping process, in contrast to the largest pores which are more sensitive
to the compaction of the packing.Comment: 8 pages, 15 figures (eps), to be published in Phys. Rev. E. Some
corrections have been made, especially in paragraph IV
Geometry of Frictionless and Frictional Sphere Packings
We study static packings of frictionless and frictional spheres in three
dimensions, obtained via molecular dynamics simulations, in which we vary
particle hardness, friction coefficient, and coefficient of restitution.
Although frictionless packings of hard-spheres are always isostatic (with six
contacts) regardless of construction history and restitution coefficient,
frictional packings achieve a multitude of hyperstatic packings that depend on
system parameters and construction history. Instead of immediately dropping to
four, the coordination number reduces smoothly from as the friction
coefficient between two particles is increased.Comment: 6 pages, 9 figures, submitted to Phys. Rev.
Nonlinear equation for anomalous diffusion: unified power-law and stretched exponential exact solution
The nonlinear diffusion equation is analyzed here, where , and , and are real parameters.
This equation unifies the anomalous diffusion equation on fractals ()
and the spherical anomalous diffusion for porous media (). Exact
point-source solution is obtained, enabling us to describe a large class of
subdiffusion (), normal diffusion () and
superdiffusion (). Furthermore, a thermostatistical basis
for this solution is given from the maximum entropic principle applied to the
Tsallis entropy.Comment: 3 pages, 2 eps figure
Exceptional uranium(VI)-nitride triple bond covalency from <sup>15</sup>N nuclear magnetic resonance spectroscopy and quantum chemical analysis.
From Europe PMC via Jisc Publications RouterHistory: ppub 2021-09-01, epub 2021-09-24Publication status: PublishedFunder: RCUK | Engineering and Physical Sciences Research Council (EPSRC); Grant(s): EP/M027015/1, EP/K024000/1, EP/S033181/1Funder: European Research Council; Grant(s): 612724Determining the nature and extent of covalency of early actinide chemical bonding is a fundamentally important challenge. Recently, X-ray absorption, electron paramagnetic, and nuclear magnetic resonance spectroscopic studies have probed actinide-ligand covalency, largely confirming the paradigm of early actinide bonding varying from ionic to polarised-covalent, with this range sitting on the continuum between ionic lanthanide and more covalent d transition metal analogues. Here, we report measurement of the covalency of a terminal uranium(VI)-nitride by 15N nuclear magnetic resonance spectroscopy, and find an exceptional nitride chemical shift and chemical shift anisotropy. This redefines the 15N nuclear magnetic resonance spectroscopy parameter space, and experimentally confirms a prior computational prediction that the uranium(VI)-nitride triple bond is not only highly covalent, but, more so than d transition metal analogues. These results enable construction of general, predictive metal-ligand 15N chemical shift-bond order correlations, and reframe our understanding of actinide chemical bonding to guide future studies
Covalent bond shortening and distortion induced by pressurization of thorium, uranium, and neptunium tetrakis aryloxides
Covalency involving the 5f orbitals is regularly invoked to explain the reactivity, structure and spectroscopic properties of the actinides, but the ionic versus covalent nature of metal-ligand bonding in actinide complexes remains controversial. The tetrakis 2,6-di-tert-butylphenoxide complexes of Th, U and Np form an isostructural series of crystal structures containing approximately tetrahedral MO(4) cores. We show that up to 3 GPa the Th and U crystal structures show negative linear compressibility as the OMO angles distort. At 3 GPa the angles snap back to their original values, reverting to a tetrahedral geometry with an abrupt shortening of the M-O distances by up to 0.1 Å. The Np complex shows similar but smaller effects, transforming above 2.4 GPa. Electronic structure calculations associate the M-O bond shortening with a change in covalency resulting from increased contributions to the M-O bonding by the metal 6d and 5f orbitals, the combination promoting MO(4) flexibility at little cost in energy
Mirror Energy Differences at Large Isospin Studied through Direct Two-Nucleon Knockout
The first spectroscopy of excited states in 52Ni (Tz=2) and 51Co (Tz=-3/2)
has been obtained using the highly selective two-neutron knockout reaction.
Mirror energy differences between isobaric analogue states in these nuclei and
their mirror partners are interpreted in terms of isospin nonconserving
effects. A comparison between large scale shell-model calculations and data
provides the most compelling evidence to date that both electromagnetic and an
additional isospin nonconserving interactions for J=2 couplings, of unknown
origin, are required to obtain good agreement.Comment: Accepted for publication in Physical Review Letter
Nonlinear anomalous diffusion equation and fractal dimension: Exact generalized gaussian solution
In this work we incorporate, in a unified way, two anomalous behaviors, the
power law and stretched exponential ones, by considering the radial dependence
of the -dimensional nonlinear diffusion equation where , ,
, and are real parameters and is a time-dependent
source. This equation unifies the O'Shaugnessy-Procaccia anomalous diffusion
equation on fractals () and the spherical anomalous diffusion for
porous media (). An exact spherical symmetric solution of this
nonlinear Fokker-Planck equation is obtained, leading to a large class of
anomalous behaviors. Stationary solutions for this Fokker-Planck-like equation
are also discussed by introducing an effective potential.Comment: Latex, 6 pages. To appear in Phys. Rev.
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