A splitting formula for the spectral flow of the odd signature operator on 3-manifolds coupled to a path of SU(2) connections

We establish a splitting formula for the spectral flow of the odd signature operator on a closed 3-manifold M coupled to a path of SU(2) connections, provided M = S cup X, where S is the solid torus. It describes the spectral flow on M in terms of the spectral flow on S, the spectral flow on X (with certain Atiyah-Patodi-Singer boundary conditions), and two correction terms which depend only on the endpoints. Our result improves on other splitting theorems by removing assumptions on the non-resonance level of the odd signature operator or the dimension of the kernel of the tangential operator, and allows progress towards a conjecture by Lisa Jeffrey in her work on Witten's 3-manifold invariants in the context of the asymptotic expansion conjecture.Comment: Published by Geometry and Topology at http://www.maths.warwick.ac.uk/gt/GTVol9/paper52.abs.htm

Lie groups and Chern-Simons Theory

Witten introduced classical Chern-Simons theory to topology in 1989, when he defined an invariant for knots in 3-manifolds by an integral over a certain infinite-dimensional space, which up to today have not been entirely understood. However, they motivated lots of interesting questions and results in knot theory and low-dimensional topology, as well as the development of entirely new fields. These are lecture notes for a course in Lie groups and Chern-Simons Theory aimed at graduate students.Comment: 77 page

The Witten-Reshetikhin-Turaev invariant for links in finite order mapping tori I

We state Asymptotic Expansion and Growth Rate conjectures for the Witten-Reshetikhin-Turaev invariants of arbitrary framed links in 3-manifolds, and we prove these conjectures for the natural links in mapping tori of finite-order automorphisms of marked surfaces. Our approach is based upon geometric quantisation of the moduli space of parabolic bundles on the surface, which we show coincides with the construction of the Witten-Reshetikhin-Turaev invariants using conformal field theory, as was recently completed by Andersen and Ueno.Comment: 41 pages. Minor changes, to appear in Adv. Mat

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.

Geometry of Music Perception

Prevalent neuroscientific theories are combined with acoustic observations from various studies to create a consistent geometric model for music perception in order to rationalize, explain and predict psycho-acoustic phenomena. The space of all chords is shown to be a Whitney stratified space. Each stratum is a Riemannian manifold which naturally yields a geodesic distance across strata. The resulting metric is compatible with voice-leading satisfying the triangle inequality. The geometric model allows for rigorous studies of psychoacoustic quantities such as roughness and harmonicity as height functions. In order to show how to use the geometric framework in psychoacoustic studies, concepts for the perception of chord resolutions are introduced and analyzed