Physical activity, fitness and adiposity: immigrants versus spanish scholars (Actividad física, condición física y adiposidad: inmigrantes versus escolares españoles)

The objective was to analyse the associations of physical fitness and patterns of physical activity with adiposity in native and foreign. This study was performed with 612 school students (8-10 years). Anthropometric measurements, physical fitness and activity patterns were studied. The results showed that students who practiced more physical activity had lower body mass index and higher levels of fitness. Immigrants had lower adiposity and higher participation in sport activities than native students. No differences between native and foreing students in levels were found, except for immigrant girls, who showed greater lower body strengh than the natives ones. In conclusion, immigrants from this study appear to have a healthier fitness, physical activity and adiposity than natives. El objetivo fue analizar las asociaciones entre los niveles de condición física, patrones de actividad física y adiposidad del alumnado nativo e inmigrante. Se estudiaron 612 niños (8-10 años) de colegios públicos, valorándose mediante pruebas antropométricas, condición física y cuestionario de hábitos de actividad física. Se observó que el alumnado que realizaba mayor actividad física presentaba menor índice de masa corporal y mayor condición física. El alumnado inmigrante presentó menor adiposidad y mayor participación en actividades deportivas. No encontramos diferencias en condición física, salvo en chicas inmigrantes, con mayor fuerza del tren inferior. En conclusión, los inmigrantes del presente estudio parecen poseer un perfil más saludable de condición física, actividad física y adiposidad que los nativos

Estimating of bootstrap confidence intervals for freight transport matrices

Freight transport studies require, as a preliminary step, a survey to be conducted on a sample of the universe of agents, vehicles and/or companies of the transportation system. The statistical reliability of the data determines the goodness of the outcomes and conclusions that can be inferred from the analyses and models generated. The methodology contained herein, based on bootstrapping techniques, allows us to generate the confidence intervals of origin-destination pairs defined by each cell of the matrix derived from a freight transport survey. To address this study a data set from a statistically reliable freight transport study conducted in Spain at the level of multi-province inter-regions has been used.Public Road Agency of the Andalusian Regional Government (AOP-JA, Spain Project G-GI3000/IDII)EU FEDE

Estimating of bootstrap confidence intervals for freight transport matrices

Freight transport studies require, as a preliminary step, a survey to be conducted on a sample of the universe of agents, vehicles and/or companies of the transportation system. The statistical reliability of the data determines the goodness of the outcomes and conclusions that can be inferred from the analyses and models generated. The methodology contained herein, based on bootstrapping techniques, allows us to generate the confidence intervals of origin-destination pairs defined by each cell of the matrix derived from a freight transport survey. To address this study a data set from a statistically reliable freight transport study conducted in Spain at the level of multi-province inter-regions has been used.Public Road Agency of the Andalusian Regional Government (AOP-JA, Spain Project G-GI3000/IDII)EU FEDE

Management of inflammation in dry eye disease: Recommendations from a European panel of experts

Introduction: Early initiation of anti-inflammatory therapies is recommended for dry eye disease (DED) to break the vicious cycle of pathophysiology. However, there is limited guidance on how to implement topical ciclosporin (CsA) and corticosteroid treatment into clinical practice. This expert-led consensus provides practical guidance on the management of DED, including when and how to use topical CsA. Methods: A steering committee (SC) of seven European DED experts developed a questionnaire to gain information on the unmet needs and management of DED in clinical practice. Consensus statements on four key areas (disease severity and progression; patient management; efficacy, safety and tolerability of CsA; and patient education) were generated based on the responses. The SC and an expanded expert panel of 22 members used a nine-point scale (1 = strongly disagree; 9 = strongly agree) to rate statements; a consensus was reached if ≥75% of experts scored a statement ≥7. Results: A stepwise approach to DED management is required in patients presenting with moderate corneal staining. Early topical CsA initiation, alone or with corticosteroids, should be considered in patients with clinical risk factors for severe DED. Patient education is required before and during treatment to manage expectations regarding efficacy and tolerability in order to optimise adherence. Follow-up visits are required, ideally at Month 1 and every 3 months thereafter. Topical CsA may be continued indefinitely, especially when surgery is required. Conclusion: This consensus fills some of the knowledge gaps in previous recommendations regarding the use of topical corticosteroids and CsA in patients with DED

Report of the Inaugural Meeting of the TFOS i2 = initiating innovation Series: Targeting the Unmet Need for Dry Eye Treatment

In March 2015, a meeting was held in London, United Kingdom, to address the progress in targeting the unmet need for dry eye disease (DED) treatment. The meeting, which launched the i2 = initiating innovation series, was sponsored by the Tear Film & Ocular Surface Society (TFOS; www.TearFilm.org) and supported by Dompé. The TFOS i2 meeting was designed to review advances in the understanding of DED since publication of the 2007 TFOS International Dry Eye WorkShop (DEWS) report, and to help launch the highly anticipated sequel, DEWS II. The meeting was structured to discuss the scope of the DED problem, to review the clinical challenges of DED, and to consider the treatment challenges of DED. This article provides a synopsis of the presentations of this TFOS i2 meeting

Safety and efficacy clinical trials for SYL1001, a novel short interfering RNA for the treatment of dry eye disease

PURPOSE. To evaluate the efficacy and safety of SYL1001, a short interfering (si) RNA targeting the transient receptor potential cation channel subfamily V member 1 (TRPV1), for the treatment of dry eye disease (DED). METHODS. This study combines a phase I and two phase II clinical trials to test different doses of SYL1001 in a total of 156 healthy subjects and patients with DED. After 10 days of treatment, the primary efficacy endpoints were the effect on (1) the scoring in the Visual Analogue Scale (VAS) and Ocular Surface Disease Index (OSDI) questionnaires, and (2) ocular tolerance evaluated by corneal fluorescein staining and conjunctival hyperemia. Secondary endpoints included the assessment of systemic and local tolerance. RESULTS. Topical administration of SYL1001 1.125% once daily produced a significant decrease in VAS scores compared with placebo from day 4 until the end of treatment (change from baseline at day 10: -1.73 ± 0.32 vs. -0.91 ± 0.34; P = 0.013). For all treatments, OSDI scores were significantly reduced compared to their respective baseline values (P < 0.01), although no significant changes were detected between groups. Conjunctival hyperemia (quantified as normal or abnormal) significantly improved after instillation of SYL1001 1.125% compared with placebo (50% vs. 20%; P < 0.05). Excellent tolerability was reported, with no differences in the rates of occurrence of adverse events between groups. CONCLUSION. These trials achieved their primary endpoints of identifying the most effective dose of SYL1001 (1.125%). SYL1001 showed a large safety margin and may provide novel therapeutic opportunity for the relief of dry eye. (ClinicalTrials.gov numbers, NCT01438281, NCT01776658, and NCT02455999.) Eliminar seleccionadoSupported by a grant from the 2012 INNPACTO program of the Spanish Ministry of Science and Innovation: INDREYE (Innovative solutions for the treatment and diagnosis of dry eye disease) grant number IPT-2012-0438-010000 (Madrid, Spain)

The HYLAN M Study: Efficacy of 0.15% High Molecular Weight Hyaluronan Fluid in the Treatment of Severe Dry Eye Disease in a Multicenter Randomized Trial

The aim of the HYLAN M study was to investigate if symptoms and/or signs of patients suffering from severe dry eye disease (DED) can be improved by substituting individually optimized artificial tear therapy by high molecular weight hyaluronan (HMWHA) eye drops. In this international, multicenter study, patients with symptoms of at least ocular surface disease index (OSDI) 33 and corneal fluorescein staining (CFS) of at least Oxford grade 3 were included. A total of 84 per-protocol patients were randomized in two study arms. The control group continued to use their individual optimum artificial tears over the study period of eight weeks; in the verum group, the artificial tears were substituted by eye drops containing 0.15% HMWHA. At the week 8 visit, the average OSDI of the verum group had improved by 13.5 as compared to the control group (p = 0.001). The best corrected visual acuity (BCVA) had improved by 0.04 logMAR (p = 0.033). CFS, tear film break-up time (TBUT), Schirmer I, lid wiper epitheliopathy (LWE), mucocutaneous junction (Yamaguchi score), and tear osmolarity were not significantly different between the verum and control groups (p > 0.050). We conclude that for most patients with severe DED, 0.15% HMWHA eye drops provide excellent improvement of symptoms without impairment of dry eye signs

TFOS Lifestyle: Impact of nutrition on the ocular surface: TFOS Lifestyle Workshop: Nutrition report

Nutrients, required by human bodies to perform life-sustaining functions, are obtained from the diet. They are broadly classified into macronutrients (carbohydrates, lipids, and proteins), micronutrients (vitamins and minerals) and water. All nutrients serve as a source of energy, provide structural support to the body and/or regulate the chemical processes of the body. Food and drinks also consist of non-nutrients that may be beneficial (e.g., antioxidants) or harmful (e.g., dyes or preservatives added to processed foods) to the body and the ocular surface. There is also a complex interplay between systemic disorders and an individual's nutritional status. Changes in the gut microbiome may lead to alterations at the ocular surface. Poor nutrition may exacerbate select systemic conditions. Similarly, certain systemic conditions may affect the uptake, processing and distribution of nutrients by the body. These disorders may lead to deficiencies in micro- and macro-nutrients that are important in maintaining ocular surface health. Medications used to treat these conditions may also cause ocular surface changes. The prevalence of nutrition-related chronic diseases is climbing worldwide. This report sought to review the evidence supporting the impact of nutrition on the ocular surface, either directly or as a consequence of the chronic diseases that result. To address a key question, a systematic review investigated the effects of intentional food restriction on ocular surface health; of the 25 included studies, most investigated Ramadan fasting (56%), followed by bariatric surgery (16%), anorexia nervosa (16%), but none were judged to be of high quality, with no randomized-controlled trials