Venous obstruction of thyroid malignancy origin: the Antoine Lacassagne Institute experience

<p>Abstract</p> <p>Background and aims</p> <p>To show the benefits of Ultrasonography in the diagnosis of great vein involvement in the neck and mediastinum in thyroid malignancies (primary or secondary) in our experience and to report patient outcomes.</p> <p>Methods</p> <p>Clinical data were collected from the thyroid unit database of the Antoine Lacassagne Institute.</p> <p>Results</p> <p>Of 1171 patients with thyroid cancer treated at our institution over the last 18 years, we retrospectively identified nine patients (0.8%), three women and six men, aged 34–81 years (median age: 70 years) presenting with malignant thyroid tumor of median diameter 45 mm (range: 23–87) having venous obstruction of thyroid malignancy origin. Two patients underwent multimodal therapy. All other patients underwent external beam radiation therapy alone ± chemotherapy or palliative care. Ultrasound (US) provided particularly useful information on venous involvement characteristics. Median survival was 7 months and median progression-free survival was 6 months. Survival in our series was worse than that of previously reported series despite diagnosis of vein involvement at an early stage in 2/3 cases using US.</p> <p>Conclusion</p> <p>Despite small numbers of patients, it seems that aggressive treatment modalities including surgery are required to improve survival. In our experience, US was a useful non-invasive method to describe tumor extensions to great veins of the neck (invasion versus compression, tumor thrombus versus blood clot) and should be recommended to depict early venous invasion in cases of suspected thyroid malignancy.</p

Association entre facteurs de risque génétique de thrombophilie et âge (Etude PATHROS) (thèse)

NICE-BU Médecine Odontologie (060882102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Phenolate and phenoxyl radical complexes of Cu(II) and Co(III), bearing a new redox active N,O-phenol-pyrazole ligand

The synthesis and characterisation of the new N,O-phenol-pyrazole pro-ligand, (LH)-L-pz, comprising a pyrazole covalently linked to an o,p-di-tert-butyl-substituted phenol, are herein reported. In CH2Cl2 at room temperature, the cyclic voltammogram (CV) of (LH)-L-pz exhibits a quasi-reversible one-electron oxidation process (at E-1/2 = 0.66 V vs. Fc(+)/Fc) attributed to the formation of the phenoxyl radical cation [(LH)-L-pz](center dot+). (LH)-L-pz reacts with M-II(BF4)(2) (M = Cu, Co) in a 2 : 1 ratio to afford the bis-(CuL2)-L-pz (1) and tris-(CoL3)-L-pz (2) complexes respectively. The X-ray structure of 1 reveals a Cu(II) ion in a square-planar trans-Cu-II-N2O2 coordination environment whereas that of 2 consists of a Co(III) ion with an octahedral mer-N3O3 coordination sphere; formed by the chelation of two (in 1) or three (in 2) N,O-bidentate phenolate ligands respectively. Both structures are preserved in CH2Cl2 solution, as revealed by their NMR (for 2) and EPR (for 1) data. The CVs of 1 and 2 consist of two (at E-1/2: 0.43 and 0.58 V vs. Fc(+)/Fc) and three (E-1/2 = 0.12, 0.54 and 0.89 V vs. Fc(+)/Fc) reversible one-electron oxidation processes, respectively. The one-electron electrochemical oxidation of 1 and 2 produces the oxidised species, 1(+) and 2(+), which are stable for several hours at room temperature under inert atmosphere in CH2Cl2. The UV/vis and EPR data obtained for 1(+) and 2(+) are unambiguously consistent with the latter being formulated as Cu(II)- and Co(III)-phenoxyl radical complexes, as [Cu-II(L-pz(center dot))(L-pz)]+ and [Co-III(L-pz(center dot))(L-pz)(2)](+) respectively