23 research outputs found
Accessory to dissipate heat from transcranial magnetic stimulation coils
Background: Transcranial magnetic stimulation (TMS) produces magnetic pulses
by passing a strong electrical current through coils of wire. Repeated stimulation
accumulates heat, which places practical constraints on experimental design.
New Method: We designed a condensation-free pre-chilled heat sink to extend
the operational duration of transcranial magnetic stimulation coils.
Results: The application of a pre-chilled heat sink reduced the rate of heating
across all tests and extended the duration of stimulation before coil overheating,
particularly in conditions where heat management was problematic.
Comparison with Existing Method: Applying an external heat sink had the
practical effect of extending the operational time of TMS coils by 5.8 to 19.3
minutes compared to standard operating procedures.
Conclusion: Applying an external heat sink increases the quantity of data that
can be collected within a single experimental session
Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib
Process
development of the synthesis of the orally active poly(ADP-ribose)polymerase
inhibitor niraparib is described. Two new asymmetric routes are reported,
which converge on a high-yielding, regioselective, copper-catalyzed <i>N</i>-arylation of an indazole derivative as the late-stage
fragment coupling step. Novel transaminase-mediated dynamic kinetic
resolutions of racemic aldehyde surrogates provided enantioselective
syntheses of the 3-aryl-piperidine coupling partner. Conversion of
the C–N cross-coupling product to the final API was achieved
by deprotection and salt metathesis to isolate the desired crystalline
salt form