descubriendo a un heroe la historia de un padre combatiente en la obra las hojas muertas de barbara jacobs

La novela de Barbara Jacobs Las hojas muertas da voz a una historia silenciada, la de Emile Jacobs, un hombre americano de origen libanes que se unio voluntario a las filas de las Brigadas Internacionales para luchar en la Guerra Civil espanola en 1937. El objetivo de este trabajo es el de recuperar, gracias a la escritura de la hija, la memoria de la experiencia de un ex-combatiente que, desde su condicion real de fracasado y perdedor, se convierte en un heroe dentro de la obra literaria

Ignacio Arellano y Carlos Mata, Vida y obra de Lope de Vega, Madrid, Homolegens (Bibliotheca Homolegens, 63), 2011, 334 pp. ISBN: 978-84-92518-72-2.

Book's revie

Ignacio Arellano y Carlos Mata, Vida y obra de Lope de Vega, Madrid, Homolegens (Bibliotheca Homolegens, 63), 2011, 334 pp. ISBN: 978-84-92518-72-2.

Book's reviewReseña de la obra

Gero Arnscheidt y Manfred Tietz, eds., "Los pre-textos del teatro áureo español. Condicionantes literarios y culturales"

Obra ressenyada: Gero ARNSCHEIDT y Manfred TIETZ (eds.), Los pre-textos del teatro áureo español. Condicionantes literarios y culturales. Madrid-Frankfurt am Main : Iberoamericana-Vervuert, 2019

Ignacio Arellano y Carlos Mata, Vida y obra de Lope de Vega, Madrid, Homolegens (Bibliotheca Homolegens, 63), 2011, 334 pp. ISBN: 978-84-92518-72-2.

Book's revie

Will PAXgene substitute formalin? A morphological and molecular comparative study using a new fixative system

Formalin fixation and paraffin embedding present the standard procedures for conserving clinical tissues for histological analysis. However, molecular analysis is impaired by the cross linking properties of formalin. The PAXgene tissue system (PreAnalytix, Switzerland) is a new formalin-free tissue collection device. AIMS: In this study we aimed to evaluate this new tissue preservation technique in comparison with formalin fixation and fresh frozen tissue samples. METHODS: 12 melanoma biopsy samples were divided and fixed simultaneously with formalin, PAXgene or fresh frozen in liquid nitrogen and analysed with regard to morphology, immunohistochemistry,  DNA and RNA content and quality. Markers of melanocytic differentiation and tumour cell proliferation were used. RESULTS: Morphology was well preserved in PAXPE samples. However, 5 out of 11 immunohistochemical markers showed significantly lower overall staining and staining intensity with PAXPE tissues in comparison with formalin-fixed, paraffin-embedded (FFPE). Increasing membrane permeability through adding a detergent did proportionally increase staining intensity in PAXPE samples. Amplification of different mRNA amplicons showed a direct relationship with the size of the amplicon with greater template integrity observed in PAXPE samples. Sequencing and mutational analysis of DNA samples were comparable for all the different fixation methods, while the level of DNA fragmentation seemed to be lower in PAXPE compared with FFPE tissues. CONCLUSIONS: The switch from formalin to PAXgene fixation would require a re-evaluation of immunohistochemical markers and staining procedures originally developed for FFPE tissues. Our data demonstrate that PAXPE fixation offers some advantages concerning molecular analysis. However, these advantages would not justify substituting formalin fixation in any routine pathology laboratory

Prognostic Value of [18F]-Fluoro-Deoxy-Glucose PET/CT, S100 or MIA for Assessment of Cancer-Associated Mortality in Patients with High Risk Melanoma

PURPOSE: To assess the prognostic value of FDG PET/CT compared to the tumor markers S100B and melanoma inhibitory activity (MIA) in patients with high risk melanoma. METHODS: Retrospective study in 125 consecutive patients with high risk melanoma that underwent FDG PET/CT for re-staging. Diagnostic accuracy and prognostic value was determined for FDG PET/CT as well as for S100B and MIA. As standard of reference, cytological, histological, PET/CT or MRI follow-up findings as well as clinical follow-up were used. RESULTS: Of 125 patients, FDG PET/CT was positive in 62 patients. 37 (29.6%) patients had elevated S100B (>100 pg/ml) and 24 (20.2%) had elevated MIA (>10 pg/ml) values. Overall specificities for FDG PET/CT, S100B and MIA were 96.8% (95% CI, 89.1% to 99.1%), 85.7% (75.0% to 92.3%), and 95.2% (86.9% to 98.4%), corresponding sensitivities were 96.8% (89.0% to 99.1%), 45.2% (33.4% to 55.5%), and 36.1% (25.2% to 48.6%), respectively. The negative predictive values (NPV) for PET/CT, S100B, and MIA were 96.8% (89.1% to 99.1%), 61.4% (50.9% to 70.9%), and 60.6% (50.8% to 69.7%). The positive predictive values (PPV) were 96.7% (89.0% to 99.1%), 75.7% (59.9% to 86.6%), and 88.0% (70.0% to 95.8%). Patients with elevated S100B- or MIA values or PET/CT positive findings showed a significantly (p<0.001 each, univariate Cox regression models) higher risk of melanoma associated death which was increased 4.2-, 6.5- or 17.2-fold, respectively. CONCLUSION: PET/CT has a higher prognostic power in the assessment of cancer-associated mortality in melanoma patients compared with S100 and MIA