Revisiting light neutralino scenarios in the MSSM

We revisit the case of a light neutralino LSP in the framework of the MSSM. We consider a model with eleven free parameters. We show that all scenarios where the annihilation of light neutralinos rely mainly on the exchange of a light pseudoscalar are excluded by direct detection searches and by Fermi measurements of the gamma-flux from dwarf spheroidal galaxies. On the other hand, we find scenarios with light sleptons that satisfy all collider and astroparticle physics constraints. In this case, the lower limit on the LSP mass is 12.6 GeV. We discuss how the parameter space of the model will be further probed by new physics searches at the LHC.Comment: 7 pages, 8 figure

Bethe Projections for Non-Local Inference

Many inference problems in structured prediction are naturally solved by augmenting a tractable dependency structure with complex, non-local auxiliary objectives. This includes the mean field family of variational inference algorithms, soft- or hard-constrained inference using Lagrangian relaxation or linear programming, collective graphical models, and forms of semi-supervised learning such as posterior regularization. We present a method to discriminatively learn broad families of inference objectives, capturing powerful non-local statistics of the latent variables, while maintaining tractable and provably fast inference using non-Euclidean projected gradient descent with a distance-generating function given by the Bethe entropy. We demonstrate the performance and flexibility of our method by (1) extracting structured citations from research papers by learning soft global constraints, (2) achieving state-of-the-art results on a widely-used handwriting recognition task using a novel learned non-convex inference procedure, and (3) providing a fast and highly scalable algorithm for the challenging problem of inference in a collective graphical model applied to bird migration.Comment: minor bug fix to appendix. appeared in UAI 201

Adverse Outcome Pathways during Early Fish Development: A Conceptual Framework for Identification of Chemical Screening and Prioritization Strategies

The fish early life-stage (FELS) test guideline (OECD 210 or OCSPP 850.1400) is the most frequently used bioassay for predicting chronic fish toxicity and supporting aquatic ecological risk assessments around the world. For each chemical, the FELS test requires a minimum of 360 fish and 1 to 3 months from test initiation to termination. Although valuable for predicting fish full life-cycle toxicity, FELS tests are labor and resource intensive and, due to an emphasis on apical endpoints, provide little to no information about chemical mode of action. Therefore, the development and implementation of alternative testing strategies for screening and prioritizing chemicals has the potential to reduce the cost and number of animals required for estimating FELS toxicity and, at the same time, provides insights into mechanisms of toxicity. Using three reference chemicals with well-established yet distinct adverse outcome pathways (AOPs) in early life stages of fish, we proposed FELS-specific AOPs as conceptual frameworks for identifying useful chemical screening and prioritization strategies. The reference chemicals selected as case studies were a cardiotoxic aryl hydrocarbon receptor agonist (2,3,7,8-tetrachlorodibenzo-p-dioxin), neurotoxic acetylcholinesterase inhibitor (chlorpyrifos), and narcotic surfactant (linear alkylbenzene sulfonate). Using qualitative descriptions for each chemical during early fish development, we developed generalized AOPs and, based on these examples, proposed a three-tiered testing strategy for screening and prioritizing chemicals for FELS testing. Linked with biologically based concentration-response models, a tiered testing strategy may help reduce the reliance on long-term and costly FELS tests required for assessing the hazard of thousands of chemicals currently in commerc

The Farm to Fork project: Community-engaged scholarship from community partners' perspective

Higher education institutions have traditionally largely ignored their role in identifying and addressing issues that their communities face. In an attempt to tackle this situation, models such as community-engaged scholarship (CES) have been developed and used to illustrate the active roles higher education institutions can play in sustainable social change. CES is guided by principles of mutually beneficial collaboration and reciprocity to address issues faced by the community. CES can guide the development of an in-depth understanding of social issues and can promote long-term and sustainable solutions. CES literature focuses largely on the impacts and benefits to students and faculty, but often ignores assessment of CES projects based on their impact on community partners and the community overall.This article illustrates the experiences of community partners in a Farm To Fork project and the impact of the project on community partners and the community at large. Developed at the University of Guelph in Ontario, Canada, the Farm To Fork project is helping increase the quantity and quality of food donated to emergency food providers, such as food banks and food pantries, via the use of online tools. Based on a survey questionnaire, the experiences of community partners are summarised under four categories: mutual benefit, resources, networking and collaborations, and raising awareness and addressing social issues. The results demonstrate that community partners greatly appreciate the effort and dedication of students and faculty. Through the project, community partners gained experience and access to university resources and formed networks with academics as well as other community organisations that will benefit them in the future. In addition, the Farm To Fork project helped to raise awareness about food insecurity, not only among students and faculty working on the project, but also in the Guelph-Wellington area.Keywords: community-engaged scholarship, food insecurity, community impacts, Farm To Fork, Guelph-Wellingto

Four Phosphonium-based Ionic Liquids. Synthesis, Characterization and Electrochemical Performance as Electrolytes for Silicon Anodes

Herein, we describe the synthesis, characterization and electrochemical performance of four phosphonium-based ionic liquids (ILs) as electrolytes, Physicochemical properties such as viscosity, density, ionic conductivity, and thermal stability of ILs and conventional organic solvent ethylene carbonate (EC)/diethyl carbonate (DEC) were experimentally determined at different temperatures. All ILs showed thermal stability greater than 300 degrees C, surpassing the stability of the conventional organic solvent, whose flash points were 145 and 23 degrees C for EC and DEC, respectively. Nevertheless, at room temperature, all ILs are much more viscous than EC/DEC. The composite Si -[P-2224][FSI] (triethyl-n-butylphosphonium bis(fluoromethylsulfonyl)imide) and Si-EC/DEC anodes exhibit initial specific capacities at 0.15 A/g of 2409 and 2631 mAh/g, respectively. This demonstrates that despite the inferior transport properties of ILs, short alkyl-substituted phosphonium ILs like [P-2224][FSI] are potentially competitive for the new generation of electrolytes for LIBs. NMR, DSC, TGA, and galvanostatic discharged/charged were used as characterization techniques.Peer reviewe

Peripheral Electrical and Magnetic Stimulation to Augment Resistance Training

Electrical stimulation (ES) and magnetic stimulation (MS), applied peripherally, may be used to elicit muscle contractions to increase muscle hypertrophy, increase muscle strength and reduce knee laxity in rehabilitation following injury. We aimed to examine the effect of a three-week exercise programme designed to induce muscle hypertrophy augmented by peripheral ES and MS. We hypothesised that the use of peripheral stimulation to augment voluntary drive during a resistance-training protocol would induce more repetitions thus leading to increased thigh circumference, muscle layer thickness, and quadriceps strength whilst decreasing knee laxity. Thirty healthy participants were divided randomly into either ES, MS or Control groups. Five resistance training sessions were carried out, consisting of four sets of quadriceps extensions. During the first three sets the participants performed eight repetitions at 85% of their 1-repetition maximum (1-RM). On the last set, the participants were instructed to perform the exercise until failure. The augmentation of peripheral stimuli allowed the MS and ES groups to continue to exercise producing, on average, 4 ± 2 and 7 ± 6 additional repetitions with ES and MS, respectively. Following the training, significant increases were observed for both 1-RM (p = 0.005) and muscle layer thickness (p = 0.031) whilst no change was observed in thigh circumference (p = 0.365). Knee laxity decreased (p = 0.005). However, there were no significant differences in the stimulation groups compared with control for any of these measurements. The additional repetitions elicited by stimulation after the point of failure suggests that peripheral electrical and/or magnetic stimulation may be useful as an adjunct for resistance training. However, this effect of resistance training augmented by peripheral stimulation on hypertrophy, strength and knee laxity may be small

In situ-formed nitrogen-doped carbon/silicon-based materials as negative electrodes for lithium-ion batteries

The development of negative electrode materials with better performance than those currently used in Li-ion technology has been a major focus of recent battery research. Here, we report the synthesis and electrochem-ical evaluation of in situ-formed nitrogen-doped carbon/SiOC. The materials were synthesized by a sol-gel pro-cess using 3-(aminopropyl)triethoxysilane (APTES), sodium citrate and glycerol. The electrochemical performance of pyrolyzed materials was studied using poly(acrylic acid) binder and commercial organic elec-trolyte. Our reported approach enables changes in both the amount of nitrogen and the morphology as a func-tion of the molar ratio of APTES:citrate and reaction time. Spherical-shaped NC/SiOC composite electrodes deliver a delithiation capacity of 622 mAh/g at 0.1 A/g and an initial coulombic efficiency of-63%, while in the large bulk material, respective values of 367 mAh/g and-55% were obtained. After 1000 charge/dis-charge cycles at 1.6 A/g, the latter material exhibits 98% of the initial capacity once it returned to lower cur-rent cycling. Overall, our results indicate that NC/SiOC materials are quite promising for electrochemical applications since both their large capacity and stability demonstrate superior performance compared to tradi-tional graphite. Moreover, our synthesis is simple and, more importantly, environmentally friendly chemicals, such as sodium citrate and glycerol, are used.Peer reviewe

Constraints on the Reheating Temperature in Gravitino Dark Matter Scenarios

Considering gravitino dark matter scenarios, we study constraints on the reheating temperature of inflation. We present the gauge-invariant result for the thermally produced gravitino yield to leading order in the Standard Model gauge couplings. Within the framework of the constrained minimal supersymmetric Standard Model (CMSSM), we find a maximum reheating temperature of about 10^7 GeV taking into account bound-state effects on the primordial $^6$Li abundance. We show that late-time entropy production can relax this constraint significantly. Only with a substantial entropy release after the decoupling of the lightest Standard Model superpartner, thermal leptogenesis remains a viable explanation of the cosmic baryon asymmetry within the CMSSM.Comment: 13 pages, 15 figures, revised version accepted for publication (reheating phase considered, improved treatment of entropy production, revised last section, references added

NAPOLI-1 phase 3 study of liposomal irinotecan in metastatic pancreatic cancer: Final overall survival analysis and characteristics of long-term survivors

BACKGROUND: Liposomal irinotecan (nal-IRI) plus 5-fluorouracil and leucovorin (5-FU/LV) is approved for patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based therapy. This approval was based on significantly improved median overall survival compared with 5-FU/LV alone (6.1 vs 4.2 months; hazard ratio [HR], 0.67) in the global phase 3 NAPOLI-1 trial. Here, we report the final survival analysis and baseline characteristics associated with long-term survivors (survival of ≥1 year) in the NAPOLI-1 trial. PATIENTS AND METHODS: Patients with mPDAC were randomised to receive nal-IRI + 5-FU/LV (n = 117), nal-IRI (n = 151), or 5-FU/LV (n = 149) for the first 4 weeks of 6-week cycles. Baseline characteristics and efficacy in the overall population were compared with those in patients who survived ≥1 year. Through 16th November 2015, 382 overall survival events had occurred. RESULTS: The overall survival advantage for nal-IRI+5-FU/LV vs 5-FU/LV was maintained from the original nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1) analysis (6.2 vs 4.2 months, respectively; HR, 0.75; 95% confidence interval: 0.57-0.99). Median progression-free survival, objective response rate and disease control rate also favoured nal-IRI+5-FU/LV therapy. Estimated one-year overall survival rates were 26% with nal-IRI+5-FU/LV and 16% with 5-FU/LV. Baseline characteristics associated with long-term survival in the nal-IRI+5-FU/LV arm were Karnofsky performance status ≥90, age ≤65 years, lower CA19-9 levels, neutrophil-to-lymphocyte ratio ≤5 and no liver metastases. No new safety concerns were detected. CONCLUSIONS: The survival benefits of nal-IRI+5-FU/LV versus 5-FU/LV were maintained over an extended follow-up, and prognostic markers of survival ≥1 year were identified. CLINICAL TRIAL REGISTRATION NUMBER: NCT01494506

The Ethical Dilemma of Information Asymmetry in Innovation: Reputation, Investors and Noise in the Innovation Channel.

A sufficient and steady stream of innovations is widely seen as a basis for healthy modern economies. Governments divert substantial resources from other purposes in society to increase innovation. Yet the failure rate among innovative SMEs is high, suggesting that resources are wasted. Avoiding such waste is a challenge for both governments and investors, but also raises a question for the innovative company, namely how to build and fund the\ud enterprise on an ethical basis. The dilemma of giving in to temptations to ‘cut corners’ clearly exists, for example to exploit the inevitable asymmetry of information arising in innovation and potentially deploy this in support of misleading claims about specific capabilities and/or the unjustified creation and exploitation of reputation. This is consistent with Olaf Fisscher’s finding that entrepreneurs starting new ventures tend to exhibit an inherent bias towards compromising their own values in order to succeed at any cost. When the innoSME’s aspirations are unrealistic or the proposed innovations are of marginal value, the ethical issues are broader and extend also to those who are potential financiers. Noting this as a gap in the ethics literature, we argue that the current situation fails to match economic and ethical ideals and that work is needed to develop tools which allow those who provide finance and support for innovation to target it more effectively at those who have a prospect of successfully launching genuine innovations and thus reduce the ‘noise’ in the innovation field