Skumle identiteter - repræsentation og regulering på netsamfundet

Denne opgave har til formål at se nærmere på individets identitetsdannelse og -regulering i forhold til sub-mainstream relationen. Dette gøres gennem en analyse af det danskbaserede netsamfund Skum.I forståelsen af dette forhold trækker opgaven på Bourdieus Habitus-begreb, post-strukturalistisk narrativitetsteori, diskursteori og endelig post-subkulturelle studier. Forholdet mellem substream og mainstream forstås her som flydende, idet de temporære substream netværk forståes som indeholdt i den hybride mainstream.For at begribe de multiple identiteter og forskellen i investeringen i disse, inddrager projektet begrebet Inkluderende Identitet, hvorved det bliver muligt at sammenkæde de i narrativen inddragede diskurser med individets positionering i forhold til sub-mainstream relationen.Gennem begrebet Inkluderende Identitet bliver det således muligt at inddrage alle de interessefelter individet indgår i uanset graden af individets tilknytning hertil. Herigennem inddrages både stil og smag i forståelsen af identitetsdannelsen.Gennem analysen af individer der deltager på en række forskellige debatter (interessefelter) på Skum, kortlægger opgaven først individernes repræsentation på profilerne, og dernæst individernes ageren på debatterne og reguleringen heraf i relation til ændringer i individernes repræsentation på profilerne. Herigennem optegner projektet en række af mulige positioner på de forskellige felter samt et hierarki af positioner på felterne.This project aims to understand the individual’s construction, representation and regulationof identity in relation to the fluent transition between the hybrid mainstream and the temporarysubstreamnetworkswithin. In doing so, the study draws on a combination of Bourdieu’sconcept of Habitus, poststructuralist understanding of the narrative, discourse theory, andfinally postsubculturalstudies.Substreams are thus understood as fields within the mainstream, where individualsposition themselves through representation and actions. The actions of the individuals onthese fields can be understood through the concept of Habitus as a structured and structuringstructure through the continuous collection of experience and action based upon it. In understandingthis collection and reconsideration of experience, it is in this project assumed that itis necessary to draw on the concept of narrative as a story of life. As a result of the multipleidentities, the individual draws on several discourses in the construction of the narrative. Inorder to comprehend these multiple identities and the difference in investment in these, theproject introduces the concept of Including Identity, through which it becomes possible tocorrelate the discourses the narrative draws upon, and the position of the individual withinthe submainstreamrelation. It’s thereby possible to map the position and regulation of theindividual through the mapping of the discoursive moments that the narrative is constructedthrough.Through this concept of Including Identity, all the interest fields of the individualregardless of the strength of relation is drawn upon in order to establish all the differentaspects of the individual’s identity. By doing so, the concepts of style and taste are includedin the understanding of identity.The object of study is the Danish based internet community Skum consisting of anumber of different theme based discussion forums. The project thus maps first the representationof the chosen individuals participating on various fields (debates), and second the actionsof the individuals on the debates and regulation thereof in relation to the changes inrepresentation. Through this the project establishes possible combinations of positioning ondifferent fields as well as a hierarchy of types of positions within the fields.MEVI350MASV-MEV

Infections in temporal proximity to HPV vaccination and adverse effects following vaccination in Denmark: A nationwide register-based cohort study and case-crossover analysis

BACKGROUND: Public trust in the human papilloma virus (HPV) vaccination programme has been challenged by reports of potential severe adverse effects. The reported adverse symptoms were heterogeneous and overlapping with those characterised as chronic fatigue syndrome (CFS) and have been described as CFS-like symptoms. Evidence suggests that CFS is often precipitated by an infection. The aim of the study was to examine if an infection in temporal proximity to HPV vaccination is a risk factor for suspected adverse effects following HPV vaccination. METHODS AND FINDINGS: The study was a nationwide register-based cohort study and case-crossover analysis. The study population consisted of all HPV vaccinated females living in Denmark, born between 1974 and 2006, and vaccinated between January 1, 2006 and December 31, 2017. The exposure was any infection in the period ± 1 month around time of first HPV vaccination and was defined as (1) hospital-treated infection; (2) redemption of anti-infective medication; or (3) having a rapid streptococcal test done at the general practitioner. The outcome was referral to a specialised hospital setting (5 national HPV centres opened June 1, 2015) due to suspected adverse effects following HPV vaccination. Multivariable logistic regression was used to estimate the association between infection and later HPV centre referral. The participants were 600,400 HPV-vaccinated females aged 11 to 44 years. Of these, 48,361 (9.7%) females had a hospital-treated infection, redeemed anti-infective medication, or had a rapid streptococcal test ± 1 month around time of first HPV vaccination. A total of 1,755 (0.3%) females were referred to an HPV centre. Having a hospital-treated infection in temporal proximity to vaccination was associated with significantly elevated risk of later referral to an HPV centre (odds ratio (OR) 2.75, 95% confidence interval (CI) 1.72 to 4.40; P < 0.001). Increased risk was also observed among females who redeemed anti-infective medication (OR 1.56, 95% CI 1.33 to 1.83; P < 0.001) or had a rapid streptococcal test (OR 1.45, 95% CI 1.10 to 1.93; P = 0.010). Results from a case-crossover analysis, which was performed to adjust for potential unmeasured confounding, supported the findings. A key limitation of the study is that the HPV centres did not open until June 1, 2015, which may have led to an underestimation of the risk of suspected adverse effects, but stratified analyses by year of vaccination yielded similar results. CONCLUSIONS: Treated infection in temporal proximity to HPV vaccination is associated with increased risk for later referral with suspected adverse vaccine effects. Thus, the infection could potentially be a trigger of the CFS-like symptoms in a subset of the referred females. To our knowledge, the study is the first to investigate the role of infection in the development of suspected adverse effects after HPV vaccination and replication of these findings are needed in other studies

Fast and sensitive detection of indels induced by precise gene targeting

The nuclease-based gene editing tools are rapidly transforming capabilities for altering the genome of cells and organisms with great precision and in high throughput studies. A major limitation in application of precise gene editing lies in lack of sensitive and fast methods to detect and characterize the induced DNA changes. Precise gene editing induces double-stranded DNA breaks that are repaired by error-prone non-homologous end joining leading to introduction of insertions and deletions (indels) at the target site. These indels are often small and difficult and laborious to detect by traditional methods. Here we present a method for fast, sensitive and simple indel detection that accurately defines indel sizes down to ±1 bp. The method coined IDAA for Indel Detection by Amplicon Analysis is based on tri-primer amplicon labelling and DNA capillary electrophoresis detection, and IDAA is amenable for high throughput analysis

Brazilian Consensus on Photoprotection

Brazil is a country of continental dimensions with a large heterogeneity of climates and massive mixing of the population. Almost the entire national territory is located between the Equator and the Tropic of Capricorn, and the Earth axial tilt to the south certainly makes Brazil one of the countries of the world with greater extent of land in proximity to the sun. The Brazilian coastline, where most of its population lives, is more than 8,500 km long. Due to geographic characteristics and cultural trends, Brazilians are among the peoples with the highest annual exposure to the sun. Epidemiological data show a continuing increase in the incidence of nonmelanoma and melanoma skin cancers. Photoprotection can be understood as a set of measures aimed at reducing sun exposure and at preventing the development of acute and chronic actinic damage. Due to the peculiarities of Brazilian territory and culture, it would not be advisable to replicate the concepts of photoprotection from other developed countries, places with completely different climates and populations. Thus the Brazilian Society of Dermatology has developed the Brazilian Consensus on Photoprotection, the first official document on photoprotection developed in Brazil for Brazilians, with recommendations on matters involving photoprotection

2009 focused updates: ACC/AHA guidelines for the management of patients with st-elevation myocardial infarction (Updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (Updating the 2005 Guideline and 2007 Focused Update)

Late-breaking clinical trials presented at the 2007 and 2008 annual scientific meetings of the ACC, AHA, Transcatheter Cardiovascular Therapeutics, the European Society of Cardiology, and the 2009 annual scientific sessions of the ACC were reviewed by the standing guideline writing committee along with the parent Task Force and other experts to identify those trials and other key data that may impact guideline recommendations. On the basis of the criteria/considerations noted above, recent trial data and other clinical information were considered important enough to prompt a focused update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction and the ACC/AHA 2005 Guidelines for Percutaneous Coronary Intervention, inclusive of their respective 2007 focused updates