63 research outputs found

    Digital Humanities in the Classroom: Bridging the Gap between Teaching and Research

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    The Department of Classics at Tufts University seeks level II funding to design and test an integrated platform on which students will collaboratively transcribe, edit, and translate Latin and Greek texts, creating vetted open source digital editions. This project, while giving students the opportunity to work with original untranslated documents, also contributes to the efforts of the scholarly community worldwide to meet the challenge of publishing large numbers of primary source documents online while preserving high editorial standards. The students' work will be vetted by experts, encoded in XML TEI following best practices in the Digital Humanities, and published online in the Tufts Digital Library and the Perseus Digital Library, which receives more than 700,000 visits a month. The integrated platform will be made available as open-source software and can be used as a model for editing and translating any source documents in any language and any Humanities field

    Aspects des similitudes entre les épopées homériques et l'élégie grecque archaïque

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    Mémoire numérisé par la Direction des bibliothÚques de l'Université de Montréal

    Agir collectivement pour mieux prévenir la violence dans les relations amoureuses : Vers des relations amoureuses égalitaires et respectueuses

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    Affiche prĂ©sentĂ©e dans le cadre du Colloque de l'ARC, «La culture de la recherche au collĂ©gial», dans le cadre du 82e CongrĂšs de l'Acfas, UniversitĂ© Concordia, MontrĂ©al, le 14 mai 2014.L'actuel plan stratĂ©gique du gouvernement du QuĂ©bec reconnaĂźt l’importance de la sensibilisation Ă  la violence dans les rapports amoureux en reconduisant la distribution de l’outil Épris sans mĂ©pris. Les rĂ©sultats de l’étude prĂ©sentĂ©s ici confirment l’importance d’agir pour diminuer la prĂ©valence (77,4 %) de la violence des rapports amoureux des cĂ©gĂ©piennes et cĂ©gĂ©piens. La violence psychologique prĂ©domine (75,7 %). Tenant compte que les jeunes utilisent les TIC, les chercheurs ont eu recours Ă  des messages diffusĂ©s via le Web afin de modifier la frĂ©quence et la force de l’intention de ne pas adresser d’insultes dans leurs Ă©changes amoureux. Les 200 sujets du groupe expĂ©rimental sont sĂ©lectionnĂ©s par Ă©chantillonnage stratifiĂ© en fonction du sexe, du style d’attachement et du nombre d’insultes, dans quatre programmes au CĂ©gep de l’Outaouais Ă  la session hiver 2013. Ils apprennent Ă  s'exprimer sans insultes en Ă©coutant des messages personnalisĂ©s pendant quatre semaines. Les messages et les feedbacks tiennent compte des variables retenues pour la stratification et de la force de l’intention de s’exprimer sans insulter. Cette dĂ©marche expĂ©rimentale est basĂ©e sur le « tailoring » et la thĂ©orie du changement planifiĂ©. Au dĂ©but de l’expĂ©rimentation, 46,4 % des sujets en couple s’expriment sans insulter leur partenaire. À la fin, 77,9 % y parviennent. Cette performance se maintient toujours aprĂšs un mois

    Flore Kimmel-Clauzet, Morts, tombeaux et cultes des poĂštes grecs

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    Dans cette Ă©tude, qui procĂšde d’une thĂšse de doctorat dĂ©fendue Ă  l’UniversitĂ© Lyon 3 en 2008, Flore Kimmel-Clauzet interroge la survie des grands poĂštes grecs dans l’imaginaire religieux, politique et culturel de l’AntiquitĂ©. C’est bel et bien de survie qu’il est question, puisque la prĂ©sence des poĂštes dans la sociĂ©tĂ© grecque continue de se faire sentir longtemps aprĂšs leur mort. En effet, les performances rĂ©pĂ©tĂ©es de leur poĂ©sie les gardent au centre des prĂ©occupations culturelles des citĂ©s..

    Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease

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    Inherited retinal disease is a common cause of visual impairment and represents a highly heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals with inherited retinal disease, who have had whole-genome sequencing (n = 605), whole-exome sequencing (n = 72), or both (n = 45) performed, as part of the NIHR-BioResource Rare Diseases research study. We identified pathogenic variants (single-nucleotide variants, indels, or structural variants) for 404/722 (56%) individuals. Whole-genome sequencing gives unprecedented power to detect three categories of pathogenic variants in particular: structural variants, variants in GC-rich regions, which have significantly improved coverage compared to whole-exome sequencing, and variants in non-coding regulatory regions. In addition to previously reported pathogenic regulatory variants, we have identified a previously unreported pathogenic intronic variant in CHM\textit{CHM} in two males with choroideremia. We have also identified 19 genes not previously known to be associated with inherited retinal disease, which harbor biallelic predicted protein-truncating variants in unsolved cases. Whole-genome sequencing is an increasingly important comprehensive method with which to investigate the genetic causes of inherited retinal disease.This work was supported by The National Institute for Health Research England (NIHR) for the NIHR BioResource – Rare Diseases project (grant number RG65966). The Moorfields Eye Hospital cohort of patients and clinical and imaging data were ascertained and collected with the support of grants from the National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital, National Health Service Foundation Trust, and UCL Institute of Ophthalmology, Moorfields Eye Hospital Special Trustees, Moorfields Eye Charity, the Foundation Fighting Blindness (USA), and Retinitis Pigmentosa Fighting Blindness. M.M. is a recipient of an FFB Career Development Award. E.M. is supported by UCLH/UCL NIHR Biomedical Research Centre. F.L.R. and D.G. are supported by Cambridge NIHR Biomedical Research Centre
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