Dise?o y construcci?n del Museo Nacional de Arqueolog?a del Per? en el distrito de Lurin, provincia de Lima

El proyecto desarrollado en la presente tesis consiste en el Dise?o y Construcci?n del Museo Nacional de Arqueolog?a del Per?. El Ministerio de Cultura ha decido invertir en la construcci?n de un nuevo museo que albergar? exclusivamente piezas arqueol?gicas a fin de poner en valor la riqueza cultural del pa?s, protegiendo el patrimonio y generando nuevos espacios para difundir la cultura. El Ministerio de Cultura, a trav?s de la Unidad Ejecutora 008 Proyectos Especiales, ha encargado a la empresa UNOPS (Oficina de la Naciones Unidas de Servicios para Proyectos) el proyecto que incluye la gesti?n del dise?o, compras, construcci?n, supervisi?n y pruebas de laboratorio del museo. Como objetivo general de la presente tesis se ha planteado desarrollar el plan de gesti?n del proyecto considerando todas las ?reas de conocimiento necesarias

Informe de la evaluación ambiental temprana en el área de influencia proyecto minero El Galeno, en los distritos de Sorochuco (provincia de Celendín) y La Encañada (provincia de Cajamarca), departamento de Cajamarca, durante el año 2017

Realiza la evaluación ambiental temprana con participación ciudadana en el área de influencia del proyecto minero El Galeno, en los distritos de Sorochuco (provincia de Celendin) y La Encañada (provincia de Cajamarca), departamento de Cajamarca, durante el año 2017. Evalúa la calidad ambiental de agua superficial, así como las condiciones de las comunidades hidrobiológicas

Increased oxygen desaturation time during sleep is a risk factor for NASH in patients with obstructive sleep apnea: A prospective cohort study

[Introduction]: Given that obstructive sleep apnea (OSA) is commonly associated with metabolic disorders, in this prospective study, we sought to determine the prevalence and risk factors for hepatosteatosis, non-alcoholic steatohepatitis (NASH), and advanced liver fibrosis in patients with clinical and polygraphic criteria of OSA (n = 153) and in subjects with normal lung function parameters (NLP, n = 43). [Methods]: Hepatosteatosis, NASH, and advanced liver fibrosis were determined by blood-based non-invasive tools, such as the fatty liver index and the hepatic steatosis index, a serum lipidomic (OWLiver™) test, and three distinct fibrosis algorithms, respectively. Logistic regression models adjusted by potential confounders were performed to evaluate risk factors. [Results]: Insulin resistance and dyslipidemia were more frequent in patients with OSA than in subjects with NLP. The prevalence of hepatosteatosis was significantly higher in patients with OSA than in subjects with NLP. NASH was also found more frequently in patients with OSA than in subjects with NLP. In contrast, advanced liver fibrosis was rarely detected in the entire study population, and no significant differences were observed between patients with OSA and subjects with NLP. Besides male gender, increased body mass index (BMI), and presence of type 2 diabetes, percentage of sleep time with oxygen saturation <90% (Tc90%) was the only polygraphic variable significantly associated with NASH in patients with OSA. [Conclusions]: This study shows that hepatosteatosis and NASH are highly prevalent in patients with OSA and indicates that those with a Tc90% higher than 10% are at increased risk for NASH.This work was supported by grants PI17/00535 and PI20/00837 from the Instituto de Salud Carlos III (ISCIII, Spain) and Fondo Europeo para el Desarrollo Regional (FEDER) to CG-M; Beca SEPAR 2016 (Sociedad Española de Neumología y Cirugía Torácica, Spain) to PL; and grants PI19/00123 from ISCIII/FEDER, Spain, Beca Eduardo Gallego 2016 (Fundación Francisco Cobos, Spain) and CIBERdem (ISCIII) to ÁG-R

Clinical features and radiological manifestations of COVID-19 disease

Coronavirus disease 2019 (COVID-19) was discovered after unusual cases of severe pneumonia emerged in December 2019 in Wuhan Province (China). Coronavirus is a family of single-stranded RNA viruses. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted from person to person. Although asymptomatic individuals can transmit the virus, symptomatic patients are more contagious. The incubation period ranges from 3-7 d and symptoms are mainly respiratory, including pneumonia or pulmonary embolism in severe cases. Elevated serum levels of interleukins (IL)-2, IL-6, IL-7 indicate the presence of cytokine release syndrome, which is associated with disease severity. The disease has three main phases: Viral infection, pulmonary involvement, and hyperinflammation. To date, no treatment has proved to be safe or effective. Chest X-ray and computed tomography (CT) are the primary imaging tests for diagnosis of SARS-CoV-2 pneumonia, follow-up, and detection of complications. The main radiological findings are ground-glass opacification and areas of consolidation. The long-term clinical course is unknown, although some patients may develop pulmonary fibrosis. Positron emission tomography-computed tomography (PET-CT) is useful to assess pulmonary involvement, to define the affected areas, and to assess treatment response. The pathophysiology and clinical course of COVID-19 infection remain poorly understood. However, patterns detected on CT and PET-CT may help to diagnose and guide treatment. In this mini review, we analyze the clinical manifestations and radiological findings of COVID-19 infection.Sin financiaciónNo data 2020UE

Actividades de coordinación del grado en Arquitectura Técnica: asignaturas del cuarto curso

El seguimiento de las titulaciones de grado por parte de las agencias de acreditación es una tarea fundamental en el sistema universitario, ya que contribuyen en la toma de decisiones y en la mejora continua de los títulos. Esta red de coordinación se enmarca en una línea prioritaria de actuación iniciada desde la coordinación del grado en Arquitectura Técnica. Como objetivo se propone examinar los principales indicadores del rendimiento académico de los estudiantes, mediante un análisis longitudinal de todas las asignaturas del cuarto curso, comparando resultados por asignatura y año académico (desde 2010-11 hasta el 2015-16). El diseño de la investigación es no experimental, de tipo descriptivo y longitudinal, utilizando una base de datos donde se ha recopilado información relevante de la muestra objeto de estudio. Se han recogido los datos sobre el número de estudiantes matriculados, presentados a examen y número de aprobados por asignatura, curso y año académico. Se ha cuantificado que las tasas de éxito de cuarto curso han sido las más altas, manteniéndose en valores superiores al 85% durante tres años académicos. Las tasas de presentados resultan ser las más bajas de todos los cursos (entre 75 y 80%)

Investigación en docencia de la nueva titulación de Grado en Ingeniería de Edificación

El trabajo que se ha desarrollado en la red de investigación en docencia de la nueva titulación de Grado en Ingeniería de Edificación ha consistido en la adaptación de los actuales estudios de la titulación de Arquitecto Técnico al Espacio Europeo de Educación Superior. Para desarrollar este trabajo se ha tenido en cuenta que la profesión de Arquitecto Técnico es una profesión regulada en nuestro país, y a partir de la cual surge la de Ingeniero de Edificación, con las mismas atribuciones profesionales que la legislación otorga al Arquitecto Técnico. El paso de una titulación de tres cursos, en la actual Arquitectura Técnica con 250 créditos, a cuatro cursos, en el nuevo Grado de Ingeniería de Edificación con 240 créditos ECTS, permitirá que la carga docente a la que se han de enfrentar los alumnos para completar su formación, esté mejor distribuida en el tiempo, permitiéndoles una mejor asimilación de contenidos y resultados académicos. Con la planificación desarrollada, que forma parte de la memoria para la verificación del Título de Graduado/a en Ingeniería de Edificación, se pretende que los alumnos adquieran los conocimientos y destrezas necesarias para desempeñar con calidad y rigor su profesión.Universidad de Alicante, Vicerrectorado de Planificación Estratégica y Calidad. Instituto de Ciencias de la Edificación

First Report of the Hyper-IgM Syndrome Registry of the Latin American Society for Immunodeficiencies: Novel Mutations, Unique Infections, and Outcomes

Hyper-IgM (HIGM) syndrome is a heterogeneous group of disorders characterized by normal or elevated serum IgM levels associated with absent or decreased IgG, IgA and IgE. Here we summarize data from the HIGM syndrome Registry of the Latin American Society for Immunodeficiencies (LASID). of the 58 patients from 51 families reported to the registry with the clinical phenotype of HIGM syndrome, molecular defects were identified in 37 patients thus far. We retrospectively analyzed the clinical, immunological and molecular data from these 37 patients. CD40 ligand (CD40L) deficiency was found in 35 patients from 25 families and activation-induced cytidine deaminase (AID) deficiency in 2 unrelated patients. Five previously unreported mutations were identified in the CD40L gene (CD40LG). Respiratory tract infections, mainly pneumonia, were the most frequent clinical manifestation. Previously undescribed fungal and opportunistic infections were observed in CD40L-deficient patients but not in the two patients with AID deficiency. These include the first cases of pneumonia caused by Mycoplasma pneumoniae, Serratia marcescens or Aspergillus sp. and diarrhea caused by Microsporidium sp. or Isospora belli. Except for four CD40L-deficient patients who died from complications of presumptive central nervous system infections or sepsis, all patients reported in this study are alive. Four CD40L-deficient patients underwent successful bone marrow transplantation. This report characterizes the clinical and genetic spectrum of HIGM syndrome in Latin America and expands the understanding of the genotype and phenotype of this syndrome in tropical areas.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Jeffrey Modell FoundationLatin American Advisory Board on Primary Immunodeficiencies initiativeUniv São Paulo, Inst Biomed Sci, Dept Immunol, BR-05508000 São Paulo, BrazilCtr Invest & Estudios, Dept Biomed Mol, Mexico City, DF, MexicoDr Ricardo Gutierrez Childrens Hosp, Buenos Aires, DF, ArgentinaHosp Nacl Ninos Dr Carlos Saenz Herrera, San Jose, Costa RicaPediat Allergy & Immunol Clin, Caxias Do Sul, RS, BrazilAlbert Sabin Hosp, Fortaleza, Ceara, BrazilHosp Base Dist Fed, Brasilia, DF, BrazilIntegrated Ctr Pediat Specialties, Curitiba, PR, BrazilHosp Ninos VJ Vilela, Rosario, ArgentinaHosp Ninos Luis Calvo Mackenna, Santiago, ChileUniv Fed Parana, Dept Pediat, BR-80060000 Curitiba, Parana, BrazilUniv Estadual Campinas, Sch Med, Dept Pediat, Campinas, SP, BrazilConceicao Childrens Hosp, Dept Pediat, Div Allergy & Immunol, Porto Alegre, RS, BrazilChildrens Hosp Lucidio Portela, Teresina, PI, BrazilPontificia Univ Catolica Chile, Div Pediat, Santiago, ChileUniv Estadual Campinas, Sch Med, Dept Med, Campinas, SP, BrazilUniv São Paulo, Ribeirao Preto Med Sch, BR-14049 Ribeirao Preto, SP, BrazilHosp Nacl Edgardo Rebagliati Martins Alergia & In, Lima, PeruUniv Fed Rio de Janeiro, Sch Med, Dept Pediat, Rio de Janeiro, BrazilInst Nacl Pediat, Unidad Invest Inmunodeficiencias, Mexico City, DF, MexicoIMSS, Unidad Med Alta Especialidad 25, Monterrey, Nuevo Leon, MexicoClin Montefiori, Unidad Inmunol, Lima, PeruUNAL, Univ Hosp, Monterrey, Nuevo Leon, MexicoFac Med ABC, Santo Andre, SP, BrazilChildrens Hosp, Dept Pediat, New Orleans, LA USAHop Necker Enfants Malad, INSERM, Unite U768, Paris, FranceUniv Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USASeattle Childrens Res Inst, Seattle, WA USAUniversidade Federal de São Paulo, Dept Pediat, Div Allergy Immunol & Rheumatol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, Div Allergy Immunol & Rheumatol, São Paulo, BrazilFAPESP: 2012/50515-4FAPESP: 2006/57643-7FAPESP: 2012/51745-3Web of Scienc

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype

Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have increasingly been identified worldwide. The clinical spectrum associated with them needed to be delineated. We enrolled 274 patients from 167 kindreds originating from 40 countries from 5 continents. Demographic data, clinical features, immunological parameters, treatment, and outcome were recorded. The median age of the 274 patients was 22 years (range, 1-71 years); 98% of them had CMC, with a median age at onset of 1 year (range, 0-24 years). Patients often displayed bacterial (74%) infections, mostly because of Staphylococcus aureus (36%), including the respiratory tract and the skin in 47% and 28% of patients, respectively, and viral (38%) infections, mostly because of Herpesviridae (83%) and affecting the skin in 32% of patients. Invasive fungal infections (10%), mostly caused by Candida spp. (29%), and mycobacterial disease (6%) caused by Mycobacterium tuberculosis, environmental mycobacteria, or Bacille Calmette-Guérin vaccines were less common. Many patients had autoimmune manifestations (37%), including hypothyroidism (22%), type 1 diabetes (4%), blood cytopenia (4%), and systemic lupus erythematosus (2%). Invasive infections (25%), cerebral aneurysms (6%), and cancers (6%) were the strongest predictors of poor outcome. CMC persisted in 39% of the 202 patients receiving prolonged antifungal treatment. Circulating interleukin-17A-producing T-cell count was low for most (82%) but not all of the patients tested. STAT1 GOF mutations underlie AD CMC, as well as an unexpectedly wide range of other clinical features, including not only a variety of infectious and autoimmune diseases, but also cerebral aneurysms and carcinomas that confer a poor prognosis