Higher than those of their race of less fortunate advantages:Race, ethnicity, and West Indian political leadership in Detroit\u27s African American community, 1885-1940

This dissertation explores West Indian immigrants in the city of Detroit and their leadership of key institutions in the African American community from 1885 to 1940. This work is divided into two parts, with the Great Migration as the line of demarcation. The research method consists largely of collective biographies and a survey of periodicals, census records, and records generated by the institutions that had West Indian leaders. The dissertation concludes that West Indian immigrants perceived middle-class status and ethnicity as a means of distinguishing themselves from their African American counterparts, but race became a more significant factor as more black Americans entered the middle class

Towards a generic research data management infrastructure

Until recent years, a focused and centralized strategy for the annotation, storage and curation of research data is something that has not been widely considered within academic communities. The majority of research data sits, fragmented, on a variety of disk structures (Desktops, network & external hard drives) and is usually managed locally, with little interest paid to policies governing how it is backed up, disseminated and organized for short or long term reuse. Recognition of how current practices and infrastructure present a barrier to research, has resulted in several recent academic programmes which have focused on developing comprehensive frameworks for the management and curation of research data1-3. Many of these frameworks (such as the Archer suite of e- Research tools1), however, are large and complex, and have an overreliance on new and novel technologies making them unwieldy and difficult to support. The paper discusses the development of a simpler framework for the management of research data through its full lifecycle, allowing users to annotate and structure their research in a secure and backed up environment. The infrastructure is being developed as a pilot system and is expected to work with data from approximately a dozen researchers and manage several Terabytes of data. The technical work is a strand of the MaDAM (Manchester Data Management) project at The University of Manchester which is funded by the JISC Managing Research Data Programme.

Development of a pilot data management infrastructure for biomedical researchers at University of Manchester – approach, findings, challenges and outlook of the MaDAM Project

Management and curation of digital data has been becoming ever more important in a higher education and research environment characterised by large and complex data, demand for more interdisciplinary and collaborative work, extended funder requirements and use of e-infrastructures to facilitate new research methods and paradigms. This paper presents the approach, technical infrastructure, findings, challenges and outlook (including future development within the successor project, MiSS) of the ‘MaDAM: Pilot data management infrastructure for biomedical researchers at University of Manchester’ project funded under the infrastructure strand of the JISC Managing Research Data (JISCMRD) programme. MaDAM developed a pilot research data management solution at the University of Manchester based on biomedical researchers’ requirements, which includes technical and governance components with the flexibility to meet future needs across multiple research groups and disciplines

Developing a Data Vault

Research data is being generated at an ever-increasing rate. This brings challenges in how to store, analyse, and care for the data. A component of this problem is the stewardship of data and associated files that need a safe and secure home for the medium to long-term. As part of typical suites of Research Data Management services, researchers are provided with large allocations of ‘active data storage’. This is often stored on expensive and fast disks to enable efficient transfer and working with large amounts of data. However, over time this active data store fills up, and researchers need a facility to move older but still valuable data to cheaper storage for long-term care. In addition, research funders are increasingly requiring data to be stored in forms that allow it to be described and retrieved in the future. For data that can’t be shared publicly in an open repository, a closed solution is required that can make use of offline or near-line storage for cost efficiency. This paper describes a solution to these requirements, called the Data Vault.

Covid-19 and the future of the digital shift amongst research libraries: an RLUK perspective in context

Research Libraries UK is a consortium of 37 of the UK and Ireland’s largest research libraries with the purpose of convening its members around the key issues that affect them, to represent their collective voice, to support them as they face shared challenges, and to be an effective advocate on their behalf. In fulfilment of these roles, RLUK launched its digital shift manifesto in May 2020, which provides a vision for the research library of 2030 - in relation to the digital shift occurring within research library collections, services, operations, and audience interactions. Centred around the four strands of skills, spaces, scholarship, and stakeholders, the manifesto provides a shared vision of the future and a tangible programme of activities through which this can be achieved. This article will explore how the Covid-19 pandemic has witnessed the digital shift in action. Combining the reflections of individual academic and research libraries, and using RLUK’s previous research into the impact of Covid-19 as a foundation, this article will reflect on how realistic and future looking the manifesto was. It will explore the collective experiences of libraries regarding the digital shift, will consider progress made in the implementation of the manifesto against this rapidly changing backdrop, and will provide a series of reflections for the future

Provenance of Cretaceous through Eocene strata of the Four Corners region: Insights from detrital zircons in the San Juan Basin, New Mexico and Colorado

Cretaceous through Eocene strata of the Four Corners region provide an excellent record of changes in sediment provenance from Sevier thin-skinned thrusting through the formation of Laramide block uplifts and intra-foreland basins. During the ca. 125–50 Ma timespan, the San Juan Basin was flanked by the Sevier thrust belt to the west, the Mogollon highlands rift shoulder to the southwest, and was influenced by (ca. 75–50 Ma) Laramide tectonism, ultimately preserving a >6000 ft (>2000 m) sequence of continental, marginal-marine, and offshore marine sediments. In order to decipher the influences of these tectonic features on sediment delivery to the area, we evaluated 3228 U-Pb laser analyses from 32 detrital-zircon samples from across the entire San Juan Basin, of which 1520 analyses from 16 samples are newly reported herein. The detrital-zircon results indicate four stratigraphic intervals with internally consistent age peaks: (1) Lower Cretaceous Burro Canyon Formation, (2) Turonian (93.9–89.8 Ma) Gallup Sandstone through Campanian (83.6–72.1 Ma) Lewis Shale, (3) Campanian Pictured Cliffs Sandstone through Campanian Fruitland Formation, and (4) Campanian Kirtland Sandstone through Lower Eocene (56.0–47.8 Ma) San Jose Formation. Statistical analysis of the detrital-zircon results, in conjunction with paleocurrent data, reveals three distinct changes in sediment provenance. The first transition, between the Burro Canyon Formation and the Gallup Sandstone, reflects a change from predominantly reworked sediment from the Sevier thrust front, including uplifted Paleozoic sediments and Mesozoic eolian sandstones, to a mixed signature indicating both Sevier and Mogollon derivation. Deposition of the Pictured Cliffs Sandstone at ca. 75 Ma marks the beginning of the second transition and is indicated by the spate of near-depositional-age zircons, likely derived from the Laramide porphyry copper province of southern Arizona and southwestern New Mexico. Paleoflow indicators suggest the third change in provenance was complete by 65 Ma as recorded by the deposition of the Paleocene Ojo Alamo Sandstone. However, our new U-Pb detrital-zircon results indicate this transition initiated ∼8 m.y. earlier during deposition of the Campanian Kirtland Formation beginning ca. 73 Ma. This final change in provenance is interpreted to reflect the unroofing of surrounding Laramide basement blocks and a switch to local derivation. At this time, sediment entering the San Juan Basin was largely being generated from the nearby San Juan Mountains to the north-northwest, including uplift associated with early phases of Colorado mineral belt magmatism. Thus, the detrital-zircon spectra in the San Juan Basin document the transition from initial reworking of the Paleozoic and Mesozoic cratonal blanket to unroofing of distant basement-cored uplifts and Laramide plutonic rocks, then to more local Laramide uplifts.National Science Foundation (NSF grant EAR-1649254

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication