Bacteriófagos no tratamento de feridas

As infecções bacterianas, particularmente as causadas por bactérias resistentes aos antibióticos, permanecem a principal causa de morte entre pacientes hospitalizados com queimaduras e feridas. Para além da terapêutica sistémica, um elemento-chave na gestão de feridas infectadas é a aplicação local de antimicrobianos eficazes. Os bacteriófagos (ou fagos) têm demonstrado um elevado potencial de cura no tratamento de feridas infectadas com estirpes bacterianas resistentes aos antibióticos.Bacterial infections, particularly the ones caused by antibiotic resistant bacteria, remain as the main cause of death among hospitalized patients with burns and ulcers. Besides systemic therapy, a key element on wound management is the local application of effective antimicrobial agents. Bacteriophages (or phages) have been shown as promising candidates (used alone or as complementary to antibiotic therapy) to target antibiotic-resistant bacteria on wound treatment

BIO4DIA: Early detection and monitoring of metabolic progression of type 2 diabetes

According to the latest International Diabetes Federation 2015 report, the total health expenditure with type 2 diabetes (T2D) spent globally was of 673 billion USD in 2015 and it expected that this effort increases up to 802 billion in 2040. Additionally, patients experienced a series of complications, ranging from eye, cardiovascular, and kidney disease as well as pregnancy complications, nerve damage, foot infections and impaired regeneration. Based on the most recent research in this area the cornerstone of treatment of T2D is the adoption of a healthy diet, increased physical activity and maintenance of a normal body weight and those are modifiable risk factors.info:eu-repo/semantics/publishedVersio

Clinical and metabolic implications of obesity in prostate cancer: is testosterone a missing link?

Objectives: To assess sex hormones in men with obesity and prostate cancer (PCa) and to study association between androgens and the pathogenesis biology of PCa in vitro. Subjects and methods: One hundred and eighty-one men older than 45 years selected from of a population attending to Urology departments screening for PCa, (78 participants without PCa and 103 patients with PCa). All participants were assessed for body mass index (BMI), age, Gleason score, and PSA. Endocrine profile was determined for LH, total testosterone (TT), 17β-estradiol (E2), prolactin and leptin. Biochemical profile (HbA1c, triacylglycerols and lipoproteins) was also determined. In vitro experiments were also performed, involving the study of 5α-dihydrotestosterone (DHT) and E2 in the presence of adipocyte-conditioned medium (aCM). Results: All variables were continuous and described a Gaussian distribution unless mentioned. To determine the relation of aggressiveness, variable were transformed into categories. Thus, PCa aggressiveness is associated with the increase of age and BMI (p < .0001) but with is decreased with TT and E2 (p < .05). Moreover, adipocyte-secreted molecules increase aggressiveness of PCa cells in vitro. Lastly, DTH but not E2 enables invasiveness in vitro. Conclusions: It was observed a coexistence of hormone axis profile alteration with sex hormones and BMI in PCa patients, in accordance with the new perspective of PCa pathogenesis.info:eu-repo/semantics/publishedVersio

Women´s education, empowerment and rural innovation

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Formación de las mujeres, empoderamiento e innovación rural

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