An early warning system for flash floods in hyper-arid Egypt

An early warning system (EWS) for flash floods has been developed for part of the Sinai peninsula of Egypt, an hyper-arid area confronted with limited availability of field data, limited understanding of the response of the wadi to rainfall, and a lack of correspondence between rainfall data and observed flash flood events. This paper shows that an EWS is not a “mission impossible” when confronted with large technical and scientific uncertainties and limited data availability. Firstly, the EWS has been developed and tested based on the best available information, this being quantita- tive data (field measurements, simulations and remote sens- ing images) complemented with qualitative “expert opinion” and local stakeholders' knowledge. Secondly, a set of essen- tial parameters has been identified to be estimated or mea- sured under data-poor conditions. These are: (1) an inven- tory of past significant rainfall and flash flood events, (2) the spatial and temporal distribution of the rainfall events and (3) transmission and infiltration losses and (4) thresholds for issuing warnings. Over a period of 30 yr (1979–2010), only 20 significant rain events have been measured. Nine of these resulted in a flash flood. Five flash floods were caused by regional storms and four by local convective storms. The re- sults for the 2010 flash flood show that 90 % of the total rain- fall volume was lost to infiltration and transmission losses. Finally, it is discussed that the effectiveness of an EWS is only partially determined by technological performance. A strong institutional capacity is equally important, especially skilled staff to operate and maintain the system and clear communication pathways and emergency procedures in case of an upcoming disaster

Vaccine Update: Recent Progress With Novel Vaccines, and New Approaches to Safety Monitoring and Vaccine Shortage

Vaccines are increasingly based on new constructs, new technologies, and new compounds. Novel immunization programs are rapidly implemented globally. In this article, we highlight selected hot topics of this highly dynamic and broad field of scientific and public health development. The first section focuses on novel vaccines including malaria, dengue, serogroup B meningococcal, and respiratory syncytial virus vaccines and antibodies. The second section is addressing emerging strategies and programmatic challenges including maternal immunization, integrated mother-child safety monitoring, and finally coping strategies with vaccine shortages

BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality

BACKGROUND/AIMS: Brown adipose tissue (BAT) dissipates energy stored in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat hyperlipidemia and obesity. BAT is densely innervated by the sympathetic nervous system, which increases BAT differentiation and activity upon cold exposure. Recently, Bone Morphogenetic Protein 7 (BMP7) was identified as an inducer of BAT differentiation. We aimed to elucidate the role of sympathetic activation in the effect of BMP7 on BAT by treating mice with BMP7 at varying ambient temperature, and assessed the therapeutic potential of BMP7 in combating obesity. ----- METHODS AND RESULTS: High-fat diet fed lean C57Bl6/J mice were treated with BMP7 via subcutaneous osmotic minipumps for 4 weeks at 21 °C or 28 °C, the latter being a thermoneutral temperature in which sympathetic activation of BAT is largely diminished. At 21 °C, BMP7 increased BAT weight, increased the expression of Ucp1, Cd36 and hormone-sensitive lipase in BAT, and increased total energy expenditure. BMP7 treatment markedly increased food intake without affecting physical activity. Despite that, BMP7 diminished white adipose tissue (WAT) mass, accompanied by increased expression of genes related to intracellular lipolysis in WAT. All these effects were blunted at 28 °C. Additionally, BMP7 resulted in extensive 'browning' of WAT, as evidenced by increased expression of BAT markers and the appearance of whole clusters of brown adipocytes via immunohistochemistry, independent of environmental temperature. Treatment of diet-induced obese C57Bl6/J mice with BMP7 led to an improved metabolic phenotype, consisting of a decreased fat mass and liver lipids as well as attenuated dyslipidemia and hyperglycemia. ----- CONCLUSION: Together, these data show that BMP7-mediated recruitment and activation of BAT only occurs at subthermoneutral temperature, and is thus likely dependent on sympathetic activation of BAT, and that BMP7 may be a promising tool to combat obesity and associated disorders