Propulsion system tests on a full scale Centaur vehicle to investigate 3-burn mission capability of the D-lT configuration

Propulsion system tests were conducted on a full scale Centaur vehicle to investigate system capability of the proposed D-lT configuration for a three-burn mission. This particular mission profile requires that the engines be capable of restarting and firing for a final maneuver after a 5-1/2-hour coast to synchronous orbit. The thermal conditioning requirements of the engine and propellant feed system components for engine start under these conditions were investigated. Performance data were also obtained on the D-lT type computer controlled propellant tank pressurization system. The test results demonstrated that the RL-10 engines on the Centaur vehicle could be started and run reliably after being thermally conditioned to predicted engine start conditions for a one, two and three burn mission. Investigation of the thermal margins also indicated that engine starts could be accomplished at the maximum predicted component temperature conditions with prestart durations less than planned for flight

Pasteurella multocida zoonotic ascending infection: an unusual cause of tubo-ovarian abscess.

We report a tubo-ovarian abscess due to Pasteurella multocida. This zoonotic infection was likely of ascending origin, as Pasteurella was also isolated from vaginal swabs

Utility of an Algorithm to Increase the Accuracy of Medication History in an Obstetrical Setting.

BACKGROUND: In an obstetrical setting, inaccurate medication histories at hospital admission may result in failure to identify potentially harmful treatments for patients and/or their fetus(es). METHODS: This prospective study was conducted to assess average concordance rates between (1) a medication list obtained with a one-page structured medication history algorithm developed for the obstetrical setting and (2) the medication list reported in medical records and obtained by open-ended questions based on standard procedures. Both lists were converted into concordance rate using a best possible medication history approach as the reference (information obtained by patients, prescribers and community pharmacists' interviews). RESULTS: The algorithm-based method obtained a higher average concordance rate than the standard method, with respectively 90.2% [CI95% 85.8-94.3] versus 24.6% [CI95%15.3-34.4] concordance rates (p<0.01). CONCLUSION: Our algorithm-based method strongly enhanced the accuracy of the medication history in our obstetric population, without using substantial resources. Its implementation is an effective first step to the medication reconciliation process, which has been recognized as a very important component of patients' drug safety

OH 12.8-0.9: A New Water-Fountain Source

We present observational evidence that the OH/IR star OH 12.8-0.9 is the fourth in a class of objects previously dubbed "water-fountain" sources. Using the Very Long Baseline Array, we produced the first images of the water maser emission associated with OH 12.8-0.9. We find that the masers are located in two compact regions with an angular separation of ~109 mas on the sky. The axis of separation between the two maser regions is at a position angle of 1.5 deg. East of North with the blue-shifted (-80.5 to -85.5 km/s) masers located to the North and the red-shifted (-32.0 to -35.5 km/s) masers to the South. In addition, we find that the blue- and red-shifted masers are distributed along arc-like structures ~10-12 mas across oriented roughly perpendicular to the separation axis. The morphology exhibited by the water masers is suggestive of an axisymmetric wind with the masers tracing bow shocks formed as the wind impacts the ambient medium. This bipolar jet-like structure is typical of the three other confirmed water-fountain sources. When combined with the previously observed spectral characteristics of OH 12.8-0.9, the observed spatio-kinematic structure of the water masers provides strong evidence that OH 12.8-0.9 is indeed a member of the water-fountain class.Comment: 12 pages, 2 figures (1 color), accepted for publication in the Ap J Letter

Waddlia chondrophila induces systemic infection, organ pathology, and elicits Th1-associated humoral immunity in a murine model of genital infection.

Waddlia chondrophila is a known bovine abortigenic Chlamydia-related bacterium that has been associated with adverse pregnancy outcomes in human. However, there is a lack of knowledge regarding how W. chondrophila infection spreads, its ability to elicit an immune response and induce pathology. A murine model of genital infection was developed to investigate the pathogenicity and immune response associated with a W. chondrophila infection. Genital inoculation of the bacterial agent resulted in a dose-dependent infection that spread to lumbar lymph nodes and successively to spleen and liver. Bacterial-induced pathology peaked on day 14, characterized by leukocyte infiltration (uterine horn, liver, and spleen), necrosis (liver) and extramedullary hematopoiesis (spleen). Immunohistochemistry demonstrated the presence of a large number of W. chondrophila in the spleen on day 14. Robust IgG titers were detected by day 14 and remained high until day 52. IgG isotypes consisted of high IgG2a, moderate IgG3 and no detectable IgG1, indicating a Th1-associated immune response. This study provides the first evidence that W. chondrophila genital infection is capable of inducing a systemic infection that spreads to major organs, induces uterus, spleen, and liver pathology and elicits a Th1-skewed humoral response. This new animal model will help our understanding of the mechanisms related to intracellular bacteria-induced miscarriages, the most frequent complication of pregnancy that affects one in four women

Heterogeneity in testing practices for infections during pregnancy: national survey across Switzerland.

QUESTION: Detection and treatment of infections during pregnancy are important for both maternal and child health. The objective of this study was to describe testing practices and adherence to current national guidelines in Switzerland. METHODS: We invited all registered practicing obstetricians and gynaecologists in Switzerland to complete an anonymous web-based questionnaire about strategies for testing for 14 infections during pregnancy. We conducted a descriptive analysis according to demographic characteristics. RESULTS: Of 1138 invited clinicians, 537 (47.2%) responded and 520 (45.6%) were eligible as they are currently caring for pregnant women. Nearly all eligible respondents tested all pregnant women for group B streptococcus (98.0%), hepatitis B virus (HBV) (96.5%) and human immunodeficiency virus (HIV) (94.7%), in accordance with national guidelines. Although testing for toxoplasmosis is not recommended, 24.1% of respondents tested all women and 32.9% tested at the request of the patient. Hospital doctors were more likely not to test for toxoplasmosis than doctors working in private practice (odds ratio [OR] 2.52, 95% confidence interval [CI] 1.04-6.13, p = 0.04). Only 80.4% of respondents tested all women for syphilis. There were regional differences in testing for some infections. The proportion of clinicians testing all women for HIV, HBV and syphilis was lower in Eastern Switzerland and the Zurich region (69.4% and 61.2%, respectively) than in other regions (range 77.1-88.1%, p <0.001). Most respondents (74.5%) said they would appreciate national guidelines about testing for infections during pregnancy. CONCLUSIONS: Testing practices for infections in pregnant women vary widely in Switzerland. More extensive national guidelines could improve consistency of testing practices

Anomalous electric conductions in KSbO3-type metallic rhenium oxides

Single crystals of KSbO3-type rhenium oxides, La4Re6O$19, Pb6Re6O19, Sr2Re3O9 and Bi3Re3O11, were synthesized by a hydrothermal method. Their crystal structures can be regarded as a network of three-dimensional orthogonal-dimer lattice of edge-shared ReO6 octahedra. All of them exhibit small magnitude of Pauli paramagnetism, indicating metallic electronic states without strong electron correlations. The resistivity of these rhenates, except Bi3Re3O11, have a temperature dependence of$rho(T)=\rho_{0}+AT^{n}$$(n \approx 1.6)$ in a wide temperature range between 5 K and 300 K, which is extraordinary for three-dimensional metals without strong electron correlations. The resistivity of Bi3Re3O11 shows an anomaly around at 50 K, where the magnetic susceptibility also detects a deviation from ordinary Pauli paramagnetism.Comment: 13 pages, 7 figures. J. Phys. Soc. Japan, in pres

OH spectral evolution of oxygen-rich late-type stars

We investigated the main-line spectral evolution with shell thickness of oxygen rich AGB stars. The study is based on a sample of 30 sources distributed along the IRAS colour-colour diagram. The sources were chosen to trace the Miras with thick shells and the whole range of OH/IR stars. The Miras exhibit a 1665 MHz emission strength comparable to that at 1667 MHz. Even though the Miras of the study have quite thick shells, their spectral characteristics in both main lines attest to a strong heterogeneity in their OH shell with, in particular, the presence of significant turbulence and acceleration. The expansion velocity has been found to be about the same at 1665 and 1667 MHz, taking into account a possible velocity turbulence of 1-2km/s at the location of the main-line maser emission. An increase in the intensity ratio 1667/1665 with shell thickness has been found. A plausible explanation for such a phenomenon is that competitive gain in favour of the 1667 MHz line increases when the shell is getting thicker. There is an evolution in the spectral profile shape with the appearance of a substantial inter-peak signal when the shell is getting thicker. Also, inter-peak components are found and can be as strong as the external standard peaks when the shell is very thick. This trend for an increase of the signal in between the two main peaks is thought to be the result of an increase of the saturation with shell thickness. All sources but two - a Mira and an OH/IR star from the lower part of the colour-colour diagram - are weakly polarized. The strong polarization observed for those two particular objects is thought to be the result of perturbations in their shells.Comment: 19 pages, 12 figures, accepted for publication in A&

Antibiotic susceptibility of Neochlamydia hartmanellae and Parachlamydia acanthamoebae in amoebae.

Parachlamydia acanthamoebae and Neochlamydia hartmanellae are Chlamydia-related bacteria naturally infecting free-living amoebae. These strict intracellular bacteria might represent emerging pathogens. Recent studies report an association with lower respiratory tract infections, especially with pneumonia where they have been identified as a potential causative agent in 1-2% of cases. In this study, we defined the antibiotic susceptibility of N. hartmanellae, two strains of P. acanthamoebae and two yet unclassified Parachlamydiaceae strains using a quantitative approach. We confirmed the results obtained earlier for P. acanthamoebae strain Bn9 in an observational study. Macrolides (MICs < 0.06-0.5 μg/ml), rifampicin (MICs 0.25-2) and doxycycline (2-4 μg/ml) were active against P. acanthamoebae strains and Neochlamydia. All strains were resistant to amoxicillin, ceftriaxone and imipenem (MIC ≥32 μg/ml). Similarly to other Chlamydia-related bacteria, all investigated Parachlamydiaceae were resistant to quinolones (MICs ≥ 16 μg/ml). Therefore, we recommend a treatment with macrolides for Parachlamydia-associated pneumonia