Incorporación de aspectos sociales en los Proyectos de Mejoras / Incorporação de aspectos sociais em Projetos de Melhoria

La creciente demanda de productos pesqueros sostenibles en el mercado ha provocado un considerable aumento en el número de proyectos de mejora de pesquerías (PROMEs). Los PROMEs son iniciativas de carácter multi-actor cuyo objetivo es mejorar una pesquería hasta alcanzar su sostenibilidad y, por consiguiente, poder obtener la certificación del programa de sostenibilidad marina del MSC [1]. Los PROMEs buscan una mejora en la gestión pesquera, la salud general de las pesquerías y la mitigación de impactos negativos en los ecosistemas, y cumplen una función en la promoción de productos pesqueros sostenibles. Sin embargo, en los últimos años, investigaciones de ONG especializadas y periodistas han resaltado la necesidad de garantizar la protección de los derechos humanos y laborales en la actividad pesquera, considerada inherentemente riesgosa. Estas solicitudes impulsan una serie de esfuerzos para que los PROMEs aborden estos temas transcendentales, y son cónsonas con las mejores prácticas internacionales descritas en el Principio 15 de los Principios Rectores de las Naciones Unidas sobre las Empresas y los Derechos Humanos [2].Una aproximación práctica a este problema es la Política de Derechos Humanos y Responsabilidad Social de FisheryProgress [3], plataforma en la que muchos PROMEs reportan sus esfuerzos para lograr la sostenibilidad pesquera.  Esta política, adoptada en mayo de 2021, propone una hoja de ruta para el abordaje de aspectos sociales, e insta a todos los líderes de PROMEs a adoptar un marco común para informar sobre el desempeño social en la pesca. CeDePesca, consciente de que cada uno de los socios de sus PROMEs están sometidos a una presión cada vez mayor para aplicar la debida diligencia y evaluar los riesgos de faltas e infracciones contra los derechos humanos a lo largo de sus cadenas de suministro, ha empezado a acompañar a sus socios en el camino hacia el cumplimiento de esta política que entrará en vigencia en noviembre de 2021.Con este fin, CeDePesca ha integrado tres de sus PROMEs al Programa de Adopción Temprana de la política social.  Para cada uno, hemos desarrollado autoevaluaciones contra criterios de alto riesgo social, hemos iniciado la recopilación de listas de embarcaciones asociadas al proyecto y la búsqueda de antecedentes respecto a mecanismos de queja y remediación existentes en estas pesquerías, y nos preparamos para instar a nuestros socios a firmar el Código de Conducta para los Derechos Humanos y la Responsabilidad Social que acompaña la nueva política de FisheryProgress.  Estas actividades se enmarcan en el contexto del componente obligatorio de la política, y entendemos que si bien su ejecución no significa que se pueda afirmar que las pesquerías están libres de abusos a los derechos humanos y laborales, sí marcan el interés de los socios por cumplir con las buenas prácticas en materia de diligencia debida en derechos humanos y responsabilidad social

A pantropical population genetics study on cashew crop: uncovering genetic diversity and agrobiodiversity hotspots

XIX ENBE Annual Meeting of the Portuguese Association for Evolutionary Biology, 18-19 December 2023, Lisboninfo:eu-repo/semantics/publishedVersio

Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer

<p>Abstract</p> <p>Background</p> <p><it>Helicobacter pylori </it>infection is one of the most common infections worldwide and is associated with gastric cancer and peptic ulcer. Bacterial virulence factors such as CagA have been shown to increase the risk of both diseases. Studies have suggested a causal role for CagA EPIYA polymorphisms in gastric carcinogenesis, and it has been shown to be geographically diverse. We studied associations between <it>H. pylori </it>CagA EPIYA patterns and gastric cancer and duodenal ulcer, in an ethnically admixed Western population from Brazil. CagA EPIYA was determined by PCR and confirmed by sequencing. A total of 436 patients were included, being 188 with gastric cancer, 112 with duodenal ulcer and 136 with gastritis.</p> <p>Results</p> <p>The number of EPIYA C segments was significantly associated with the increased risk of gastric carcinoma (OR = 3.08, 95% CI = 1.74 to 5.45, p < 10^-3) even after adjustment for age and gender. Higher number of EPIYA C segments was also associated with gastric atrophy (p = 0.04) and intestinal metaplasia (p = 0.007). Furthermore, patients infected by <it>cag</it>A strains possessing more than one EPIYA C segment showed decreased serum levels of pepsinogen I in comparison with those infected by strains containing one or less EPIYA C repeat. Otherwise, the number of EPIYA C segments did not associate with duodenal ulcer.</p> <p>Conclusions</p> <p>Our results demonstrate that infection with <it>H. pylori </it>strains harbouring more than one CagA EPIYA C motif was clearly associated with gastric cancer, but not with duodenal ulcer.</p> <p>Higher number of EPIYA C segments was also associated with gastric precancerous lesions as demonstrated by histological gastric atrophic and metaplastic changes and decreased serum levels of pepsinogen I.</p

Ficção científica na transposição didática do conceito de Entropia: a última pergunta de Isaac Asimov [Science fiction in the didactic transposition of the concept of Entropy: Isaac Asimov’s last question]

This paper presents and analyzes the methodology for teaching the concept of entropy supported by a science fiction text. In previous publications, we have presented ways of articulating Ausubel’s Meaningful Learning and Matthew Lipman’s Education theories, the object of his Philosophy Program. We show how this articulation considers the prerogatives of meaningful learning, linking it to higher-order thinking established by research communities and suggesting aggregating methods. As a theoretical-methodological expansion of these references, we transferred the notion of didactic transposition, via science fiction texts, to reinforce these postulates about teaching and cognition. The translational research involved researchers from the field of Physics teaching and 58 second-year high school students from a public institution. In the pedagogical mediation, as a basis for the discussion of the concept of entropy in the Second Law of Thermodynamics, we use one of the most acclaimed short stories by the popular Russian-American author, Isaac Asimov, entitled “The Last Question”. For data analysis, we resorted to techniques of semantic frequency and medium order of evocation as constructs of a taxonomy for the investigation of social representations arising from the implemented proposition. The results indicated consistency with the perspective of meaningful learning, consolidating reflections for similar interventions and contiguous research

Cognitive impairment and magnetic resonance imaging correlates in primary progressive multiple sclerosis

Objectives: To characterize cognitive impairment in primary progressive multiple sclerosis (PPMS) and to correlate the pattern of cognitive deficits with brain magnetic resonance imaging (MRI) volumetric data. Materials and methods: In a multicenter cross-sectional study, we recruited consecutive patients with PPMS as well as age, sex, and education level-matched healthy controls (HC). All participants underwent neuropsychological (NP) assessment, and brain MRI was performed in patients with PPMS for analysis of lesion load, subcortical GM volumes, and regional cortical volumes. Results: We recruited 55 patients with PPMS and 36 HC. Thirty-six patients were included in the MRI analysis. Patients with PPMS performed significantly worse than HC in all NP tests. Subcortical GM volume was significantly correlated with all NP tests, except for Stroop Test, with the largest effect for the thalamus (r=−.516 [BVMT-R DR, P=.016 FDR-corrected] to r=.664 [SDMT, P<.001 FDR-corrected]). In the stepwise linear regression model, thalamic volume was the only predictor of performance in all NP tests. Conclusion: Cognitive impairment is common in PPMS and affects all evaluated cognitive domains. Subcortical GM volume, particularly of the thalamus, is a strong predictor of cognitive performance, suggesting it has a central role in the pathophysiology of PPMS-related cognitive dysfunction

Treatment planning systems dosimetry auditing project in Portugal

BACKGROUND AND PURPOSE: The Medical Physics Division of the Portuguese Physics Society (DFM_SPF) in collaboration with the IAEA, carried out a national auditing project in radiotherapy, between September 2011 and April 2012. The objective of this audit was to ensure the optimal usage of treatment planning systems. The national results are presented in this paper. MATERIAL AND METHODS: The audit methodology simulated all steps of external beam radiotherapy workflow, from image acquisition to treatment planning and dose delivery. A thorax CIRS phantom lend by IAEA was used in 8 planning test-cases for photon beams corresponding to 15 measuring points (33 point dose results, including individual fields in multi-field test cases and 5 sum results) in different phantom materials covering a set of typical clinical delivery techniques in 3D Conformal Radiotherapy. RESULTS: All 24 radiotherapy centers in Portugal have participated. 50 photon beams with energies 4-18 MV have been audited using 25 linear accelerators and 32 calculation algorithms. In general a very good consistency was observed for the same type of algorithm in all centres and for each beam quality. CONCLUSIONS: The overall results confirmed that the national status of TPS calculations and dose delivery for 3D conformal radiotherapy is generally acceptable with no major causes for concern. This project contributed to the strengthening of the cooperation between the centres and professionals, paving the way to further national collaborations

Insight into aquaculture's potential of marine annelid worms and ecological concerns: a review

Polychaetes are marine annelid worms that can contribute to aquaculture diversification. Its culture has been viable, and commercially attempted, but intensive production has progressed only in few countries around the world. In the countries with no production, marine polychaetes are imported or harvested. A strong and sustained research investment provided to a better understanding of the nutritional requirements and reproduction of some species. Recent studies showed new technical improvements, which can lead to an important progress in productivity and give a new impetus to the polychaete production. Some marine worm species were identified as good candidates for integrated multitrophic aquaculture. The development of cost-effective aquaculture techniques for marine annelid worms is essential to ensure a balance between commercial interests and the preservation of ecosystems. The influence of polychaete aquaculture on the environment and vice versa raise important concerns related to ecological security and sustainability of this activity. This review focus on the main technical improvements and advances that have been made in areas as diverse as: aquaculture potential of polychaetes, reared species, main species used worldwide, and highlights biological and ecological concerns, important challenges and recommendations.This study was supported by the FCT (Portuguese National Board of Scientific Research), through the MARE (Marine and Environmental Sciences Centre) (UID/MAR/04292/2013) strategic programme and through strategic project PEst-OE/MAR/UI0199/2014, granted to MARE. This study has also the financial support of PROMAR Program through the project 31-03-05-FEP42: LIVE BAIT – Annelid polychaetes as live bait in Portugal: harvesting, import and rearing management.info:eu-repo/semantics/publishedVersio

Conservation and divergence within the clathrin interactome of <i>Trypanosoma cruzi</i>

Trypanosomatids are parasitic protozoa with a significant burden on human health. African and American trypanosomes are causative agents of Nagana and Chagas disease respectively, and speciated about 300 million years ago. These parasites have highly distinct life cycles, pathologies, transmission strategies and surface proteomes, being dominated by the variant surface glycoprotein (African) or mucins (American) respectively. In African trypanosomes clathrin-mediated trafficking is responsible for endocytosis and post-Golgi transport, with several mechanistic aspects distinct from higher organisms. Using clathrin light chain (TcCLC) and EpsinR (TcEpsinR) as affinity handles, we identified candidate clathrin-associated proteins (CAPs) in Trypanosoma cruzi; the cohort includes orthologs of many proteins known to mediate vesicle trafficking, but significantly not the AP-2 adaptor complex. Several trypanosome-specific proteins common with African trypanosomes, were also identified. Fluorescence microscopy revealed localisations for TcEpsinR, TcCLC and TcCHC at the posterior region of trypomastigote cells, coincident with the flagellar pocket and Golgi apparatus. These data provide the first systematic analysis of clathrin-mediated trafficking in T. cruzi, allowing comparison between protein cohorts and other trypanosomes and also suggest that clathrin trafficking in at least some life stages of T. cruzi may be AP-2-independent