Inclusion and Exclusion in Medieval European Craft Guilds.

This essay examines the effect of European craft guilds on early European society. Specifically, it focuses on guilds’ impacts on women, Jews, and its own members. This historical analysis overwhelmingly finds that while European craft guilds fostered community for their members, they had the opposite, dividing, effect on excluded non-member populations. For members of a craft guild, participation meant access to expanding opportunities and greater social status and mobility. Guilds ensured members fair wages, equal chances for success, advancement of skulls and social status, and a sense of stability. Guilds acted much like a social network, hosting a wide variety of activities that fostered cohesion and cooperation. Evidence indicated that some women were able to participate in guild life, though the scope of that participation was quite limited; Jews were barred from guilds entirely. Because guilds reserved the rights to certain skilled trades, Jews and women were denied many potential livelihoods. The essay ultimately explores the historical implications of such guild inclusion and exclusion

Introduction to this special section: The role of geophysics in a net-zero-carbon world

Human activities are changing the earth's climate, causing increasingly disruptive social and ecological impacts. These impacts can be reduced if global carbon dioxide (CO2) emissions reach net zero in the near future. A net-zero-carbon world can be achieved by using energy more efficiently and responsibly; transitioning toward energy sources, products, and services that minimize greenhouse gas release; and implementing existing and novel technologies to remove and store CO2 from the atmosphere

Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylation

Despite being unable to activate the cognate ghrelin receptor (GHS-R), unacylated ghrelin (UAG) possesses a unique activity spectrum that includes promoting bone marrow adipogenesis. Since a receptor mediating this action has not been identified, we re-appraised the potential interaction of UAG with GHS-R in the regulation of bone marrow adiposity. Surprisingly, the adipogenic effects of intra-bone marrow (ibm)-infused acylated ghrelin (AG) and UAG were abolished in male GHS-R-null mice. Gas chromatography showed that isolated tibial marrow adipocytes contain the medium-chain fatty acids utilised in the acylation of UAG, including octanoic acid. Additionally, immunohistochemistry and immunogold electron microscopy revealed that tibial marrow adipocytes show prominent expression of the UAG-activating enzyme ghrelin O-acyl transferase (GOAT), which is located in the membranes of lipid trafficking vesicles and in the plasma membrane. Finally, the adipogenic effect of ibm-infused UAG was completely abolished in GOAT-KO mice. Thus, the adipogenic action of exogenous UAG in tibial marrow is dependent upon acylation by GOAT and activation of GHS-R. This suggests that UAG is subject to target cell-mediated activation – a novel mechanism for manipulating hormone activity

Quantifying compressible groundwater storage by combining cross-hole seismic surveys and head response to atmospheric tides

Groundwater specific storage varies by orders of magnitude, is difficult to quantify, and prone to significant uncertainty. Estimating specific storage using aquifer testing is hampered by the nonuniqueness in the inversion of head data and the assumptions of the underlying conceptual model. We revisit confined poroelastic theory and reveal that the uniaxial specific storage can be calculated mainly from undrained poroelastic properties, namely, uniaxial bulk modulus, loading efficiency, and the Biot-Willis coefficient. In addition, literature estimates of the solid grain compressibility enables quantification of subsurface poroelastic parameters using field techniques such as cross-hole seismic surveys and loading efficiency from the groundwater responses to atmospheric tides. We quantify and compare specific storage depth profiles for two field sites, one with deep aeolian sands and another with smectitic clays. Our new results require bulk density and agree well when compared to previous approaches that rely on porosity estimates. While water in clays responds to stress, detailed sediment characterization from a core illustrates that the majority of water is adsorbed onto minerals leaving only a small fraction free to drain. This, in conjunction with a thorough analysis using our new method, demonstrates that specific storage has a physical upper limit of (Formula presented.) m−1. Consequently, if larger values are derived using aquifer hydraulic testing, then the conceptual model that has been used needs reappraisal. Our method can be used to improve confined groundwater storage estimates and refine the conceptual models used to interpret hydraulic aquifer tests

Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis

Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass, yet unlike white or brown adipose tissues (WAT or BAT) its metabolic functions remain unclear. Herein, we address this critical gap in knowledge. Our transcriptomic analyses revealed that BMAT is distinct from WAT and BAT, with altered glucose metabolism and decreased insulin responsiveness. We therefore tested these functions in mice and humans using positron emission tomography-computed tomography (PET/CT) with 18F-fluorodeoxyglucose. This revealed that BMAT resists insulin- and cold-stimulated glucose uptake, while further in vivo studies showed that, compared to WAT, BMAT resists insulin-stimulated Akt phosphorylation. Thus, BMAT is functionally distinct from WAT and BAT. However, in humans basal glucose uptake in BMAT is greater than in axial bones or subcutaneous WAT and can be greater than that in skeletal muscle, underscoring the potential of BMAT to influence systemic glucose homeostasis. These PET/CT studies characterise BMAT function in vivo, establish new methods for BMAT analysis, and identify BMAT as a distinct, major adipose tissue subtype