Construction grammar and prosody : OH in English everyday interaction

Peer reviewe

Integrative medicine during the intensive phase of chemotherapy in pediatric oncology in Germany: a randomized controlled trial with 5-year follow up

Background: Integrative medicine is used frequently alongside chemotherapy treatment in pediatric oncology, but little is known about the influence on toxicity. This German, multi-center, open-label, randomized controlled trial assessed the effects of complementary treatments on toxicity related to intensive-phase chemotherapy treatment in children aged 1-18 with the primary outcome of the toxicity sum score. Secondary outcomes were chemotherapy-related toxicity, overall and event-free survival after 5 years in study patients. Methods: Intervention and control were given standard chemotherapy according to malignancy & tumor type. The intervention arm was provided with anthroposophic supportive treatment (AST); given as anthroposophic base medication (AMP), as a base medication for all patients and additional on-demand treatment tailored to the intervention malignancy groups. The control was given no AMP. The toxicity sum score (TSS) was assessed using NCI-CTC scales. Results: Data of 288 patients could be analyzed. Analysis did not reveal any statistically significant differences between the AST and the control group for the primary endpoint or the toxicity measures (secondary endpoints). Furthermore, groups did not differ significantly in the five-year overall and event-free survival follow up. Discussion: In this trial findings showed that AST was able to be safely administered in a clinical setting, although no beneficial effects of AST between group toxicity scores, overall or event-free survival were shown

The Electron Capture in 163^{163} Ho Experiment - a Short Update

The definition of the absolute neutrino mass scale is one of the main goals of the Particle Physics today. The study of the end-point regions of the β- and electron capture (EC) spectrum offers a possibility to determine the effective electron (anti-)neutrino mass in a completely model independent way, as it only relies on the energy and momentum conservation. The ECHo (Electron Capture in 163Ho) experiment has been designed in the attempt to measure the effective mass of the electron neutrino by performing high statistics and high energy resolution measurements of the 163 Ho electron capture spectrum. To achieve this goal, large arrays of low temperature metallic magnetic calorimeters (MMCs) implanted with with 163Ho are used. Here we report on the structure and the status of the experiment

Data reduction for a calorimetrically measured

The electron capture in $$^{163}\mathrm {Ho}$$ experiment (ECHo) is designed to directly measure the effective electron neutrino mass by analysing the endpoint region of the $$^{163}\mathrm {Ho}$$ electron capture spectrum. We present a data reduction scheme for the analysis of high statistics data acquired with the first phase of the ECHo experiment, ECHo-1k, to reliably infer the energy of $$^{163}\mathrm {Ho}$$ events and discard triggered noise or pile-up events. On a first level, the raw data is filtered purely based on the trigger time information of the acquired signals. On a second level, the time profile of each triggered event is analysed to identify the signals corresponding to a single energy deposition in the detector. We demonstrate that events not belonging to this category are discarded with an efficiency above 99.8%, with a minimal loss of $$^{163}\mathrm {Ho}$$ events of about 0.7%. While the filter using the trigger time information is completely energy independent, a slight energy dependence of the filter based on the time profile is precisely characterised. This data reduction protocol will be important to minimise systematic errors in the analysis of the $$^{163}\mathrm {Ho}$$ spectrum for the determination of the effective electron neutrino mass

Numerical Calculation of the Thermodynamic Properties of Silver Erbium Alloys for Use in Metallic Magnetic Calorimeters

Using dilute silver erbium alloys as a paramagnetic temperature sensor in metallic magnetic calorimeters (MMCs) has the advantage of the host material not having a nuclear quadrupole moment, in contrast to the alternative of using gold erbium alloys. We present numerical calculations of the specific heat and magnetization of Ag:Er, which are necessary for designing and optimizing MMCs using this type of alloy as sensor material. The parameter ranges we consider are temperatures between 1{mK} and 1{K}, external magnetic fields of up to 20{mT}, and erbium concentrations of up to 2000{ppm}. The system is dominated by an interplay of crystal field effects, Zeeman splitting, and the RKKY interaction between erbium ions, with certain specific constellations of erbium ions having noticeable effects on the specific heat. Increasing the external magnetic field or assuming a decreased strength of the RKKY interaction leads to a higher magnetization and a narrowing of the main Schottky peak, while changes in the erbium concentration can be well described by parameter scaling

Numerical Calculation of the Thermodynamic Properties of Silver Erbium Alloys for Use in Metallic Magnetic Calorimeters - Data

Data from simulations of the specific heat and magnetization of Ag:Er alloys. The parameter range we consider are temperatures between 1mK and 1K, external magnetic fields of up to 20mT, and erbium concentrations of up to 2000ppm.Part of this research was performed in the framework of the DFG Research Unit FOR2202 "Neutrino Mass Determination by Electron Capture in 163Ho, ECHo" (funding under EN 299/7-1 and EN 299/7-2, EN 299/8-1, GA 2219/2-1 and GA 2219/2-2). The research leading to these results has received funding from the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement no 824109 (European Microkelvin Platform). A. Barth and F. Mantegazzini acknowledge funding from the Research Training Group HighRR (GRK 2058) funded through the Deutsche Forschungsgemeinschaft, DFG

Gesprächsanalytisches Transkriptionssystem 2 (GAT 2)

Selting M, Auer P, Barth-Weingarten D, et al. Gesprächsanalytisches Transkriptionssystem 2 (GAT 2). Gesprächsforschung - Online-Zeitschrift zur verbalen Interaktion. 2009;10:353-402.This article presents a revised version of GAT, a transcription system first developed by a group of German conversation analysts and interactional linguists in 1998. GAT tries to follow as many principles and conventions of CA's Jeffersonstyle transcription as possible, yet proposes some conventions which are more compatible with linguistic and phonetic analyses of spoken language, especially for the representation of prosody in talk-in-interaction. After ten years of use by many reseachers in conversation and discourse analysis, it was time to revise the first version, against the background of past experience and in light of new necessities for the transcription of corpora arising from technological advances and methodological developments over recent years. This text presents the new GAT 2 transcription system with all its conventions. It gives detailed instructions on how to transcribe spoken talk on three levels of delicacy: minimal, basic and refined transcript versions. In addition, it briefly introduces a few tools that may be helpful for the user: the online tutorial GAT-TO and the transcription editing software FOLKER.Der Beitrag stellt eine aktualisierte Version des Gesprächsanalytischen Transkriptionssystems (GAT) dar. Nachdem GAT seit seiner Erstvorstellung im Jahr 1998 in der Gesprächsforschung eine breite Verwendung gefunden hat, war es nun an der Zeit, es aufgrund der bisherigen Erfahrungen und im Hinblick auf neue Anforderungen an Transkriptionen vorsichtig zu überarbeiten. Dieser Text stellt das aktualisierte GAT 2-Transkriptionssystem mit allen seinen alten und neuen Konventionen dar, versucht bekannte Zweifelsfälle zu klären und bekannte Schwächen der ersten Version zu beheben. GAT 2 gibt detaillierte Anweisungen zum Erstellen gesprächsanalytischer Transkriptionen auf drei Detailliertheitsstufen, dem Minimal-, Basis- und Feintranskript, sowie neue Vorschläge zur Darstellung komplexerer Phänomene in Sonderzeilen. Zudem wurden für GAT 2 einige zusätzliche Hilfsmittel entwickelt, die im Anhang kurz vorgestellt werden: das Online-Tutorial GAT-TO sowie der Transkriptionseditor FOLKER

Integrative medicine during the intensive phase of chemotherapy in pediatric oncology in Germany: a randomized controlled trial with 5-year follow up

Background Integrative medicine is used frequently alongside chemotherapy treatment in pediatric oncology, but little is known about the influence on toxicity. This German, multi-center, open-label, randomized controlled trial assessed the effects of complementary treatments on toxicity related to intensive-phase chemotherapy treatment in children aged 1-18 with the primary outcome of the toxicity sum score. Secondary outcomes were chemotherapy-related toxicity, overall and event-free survival after 5 years in study patients. Methods Intervention and control were given standard chemotherapy according to malignancy & tumor type. The intervention arm was provided with anthroposophic supportive treatment (AST); given as anthroposophic base medication (AMP), as a base medication for all patients and additional on-demand treatment tailored to the intervention malignancy groups. The control was given no AMP. The toxicity sum score (TSS) was assessed using NCI-CTC scales. Results Data of 288 patients could be analyzed. Analysis did not reveal any statistically significant differences between the AST and the control group for the primary endpoint or the toxicity measures (secondary endpoints). Furthermore, groups did not differ significantly in the five-year overall and event-free survival follow up. Discussion In this trial findings showed that AST was able to be safely administered in a clinical setting, although no beneficial effects of AST between group toxicity scores, overall or event-free survival were shown