Revistas electrónicas y noralización.

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Guía para la evaluación de repositorios institucionales de investigación

Esta es la tercera versión de la Guía para la evaluación de repositorios institucionales de investigación, cuya primera edición fue publicada por RECOLECTA en Diciembre de 2010.Guia realitzada amb el suport de la Fundación Española para la Ciencia y la Tecnología i Crue Universidades EspañolasEsta nueva versión de la Guía para la evaluación de repositorios institucionales de investigación tiene como finalidad principal el seguir siendo instrumento de auditoría interna para mejorar la calidad de los repositorios. Disponer de esta herramienta de autoevaluación supone una importante ayuda a la hora de detectar puntos fuertes y áreas de mejora, lo cual contribuye a incrementar el alcance y la visibilidad de los repositorios entre la comunidad científica. Además, para los repositorios que se encuentran en fase de planificación, este documento ofrece las pautas necesarias a tener en cuenta para crear una infraestructura robusta y visible. Esta guía está dirigida primordialmente a los profesionales implicados en la gestión de repositorios científicos: responsables, administradores, gestores, técnicos o personal de apoyo. Para elaborarla se ha constituido un grupo de trabajo, en el marco de la colaboración FECYT-REBIUN

Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Background Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021)

Demoras diagnósticas en el cáncer de pulmón

Objetivo: Estudio de los factores clínicos y demográficos asociados a las demoras diagnósticas del cáncer de pulmón (CP). Pacientes y métodos: Estudio prospectivo de dos años de evolución de pacientes ingresados en la planta de neumología por sospecha de CP. Se estudiaron variables demográficas, de atención sanitaria, hábitat y demoras en las exploraciones. Se definieron los tiempos diagnósticos siguientes: de consulta (desde el primer síntoma hasta la visita del primer médico), medio (el que va desde la visita médica hasta el ingreso) y diagnóstico (desde el ingreso hasta el diagnóstico histológico y la estadificación clínica). Resultados: Se estudió a 113 pacientes con una edad media de 65 años (intervalo, 36-90), de los que 103 eran varones y 10, mujeres. Los síntomas más frecuentes por los que consultó el paciente fueron: tos (10,6%), hemoptisis (19,5%), dolor torácico (26,5%) y disnea (9,7%). El 72% de los pacientes consultaba por primera vez al médico de atención primaria (MAP), el 22% a urgencias del hospital y el 6% al neumólogo. El 44% realizó entre dos y tres visitas al médico. Las medias ± desviaciones típicas, en días, de los diferentes tiempos fueron: consulta, 30,3 ± 60; diagnóstico, 18,6 ± 19; medio, 37,9 ± 63, y total, 85,7 ± 87. El tiempo medio, el tiempo hasta el diagnóstico y el tiempo total fueron inferiores cuando el paciente fue remitido, por el MAP, a urgencias o ingresado directamente en el hospital (p < 0,001). Sólo el 25,7% de los CP estadificados eran resecables quirúrgicamente. Conclusiones: Los tiempos de demora diagnóstica en el CP son elevados. La actitud del MAP y su relación con la atención especializada es importante para su reducción

Guía para la evaluación de repositorios institucionales de investigación

Partiendo del estudio de la situación actual de los repositorios institucionales de investigación españoles, se quieren elaborar una serie de directrices que permitan la la creación y evaluación de los mismos.Peer reviewe

Anales de Edafología y Agrobiología Tomo 37 Número 7-8

Mineralogía de las fracciones arenosas de suelos desarrollados sobre serpentinas en la Sierra de Carratraca (Málaga), por A. García y M. Delgado.-- Estudio sobre la infección y nodulación de Alnus glutinosa (L.) Gaertn. por su endofito simbionte, por C. Rodríguez-Barrueco, F. Bermúdez de Castro, A. Costa y C. Miguel.-- Efecto de la inoculación de un suelo con P, sobre la nutrición vegetal, por Mª D. Simón-Pujol, F. Congregado, Mª T. Felipe y A. Ramos-Cormenzana.-- Contribución al estudio de la «Enfermedad de Panamá en la platanera canaria. 1. Sustancias reguladoras del crecimiento aisladas de cultivos de Fusarium oxypomm cubense, por M. A. Rodríguez Raymond, C. Prendes, C. Dolores Lorenzo y A. Carlos Blesa.-- Mineralogía y génesis de suelos con horizonte B textura! sobre rocas calizas en el Sureste de España, por L. J. Alías y J. Albaladejo.-- Estudio comparativo de diversos métodos para la extracción conjunta de los óxidos libres de Fe, Al y Si en suelos, por J. Fernández, J. Aguilar, C. Dorronsoro y M. Pino.-- Contenido de L-Dopa y su precursor L-Tirosina en Vicia faba cultivada en el Norte de Navarra, por M. N. Cenarruzabeitia, A. Soria y J. Larralde.-- Cultivo de la lavanda: nutrición mineral. l. Primeros resultados, por S. Fernández Fábregas y E. Martín Ramírez.-- Notas sobre técnicas de investigación de sustancias húmicas. l. Aplicación de la respirometría, por J. F. Gallardo y M. I. M. González.-- Notas sobre técnicas de investigación de sustancias húmicas. II. Aplicación de la cromatografía en columna, por J. F. Gallardo y M. l. M. González.-- Cuantificación de fitohormonas en cultivos de Rhizobium spp. usados en fertilización biológica, por I. M. Sánchez-Calle, J. M. Barea y L. Recalde.-- Estudios sobre la resistencia de Lolium perenne L. al Dalapón. II. Experiencias de invernadero: tratamientos en postemergencia, por J. Segura, R. Fábregas y E. Vieitez.-- Suelos formados sobre materiales volcánicos (Islas Canarias). Aridisoles: Natrargids, Calciorthids. l. Características generales de estos suelos, por E. Fernández Caldas y C. M. Rodríguez Hernández.-- Vertisoles formados sobre materiales volcánicos (Islas Canarias). Typic Chromusterts. II. Características morfológicas, físico-químicas y mineralógicas, por E. Fernández Caldas y C. M. Rodríguez Hernández.-- Nota previa.-- El sistema Larsys Nuevo método para estudiar recursos naturales, por J. L. Labandero.-- Notas.-- Congreso de Ciencia del Suelo. Edmonton (Canadá).-- Presidentes y Vicepresidentes de Comisiones y Subcomisiones de la l. S. S. S. para el período 1978-82.-- Directivos de los nuevos Grupos de Trabajo de la l. S. S. S. 1978-82.-- Actividades Intercongresos de la l. S. S. S. propuestas para el período 1978-82.-- Declaraciones del Ministro de Educación y Ciencia sobre política científica.-- VII Curso Internacional de Fertilidad de Suelos y Nutrición Vegetal.-- Viaje del Profesor Hoyos a Méjico.-- II Reunión del grupo para el estudio del humus del C. S. l. C.-- Conferencias del Profesor Glinski.-- Conferencia del Profesor Jacquin.-- Conferencia del Ingeniero Donezar Díez de Ulzurrum.-- Actividades de la Jefe del Servicio de Documentación y Bibliotecas del Instituto de Edafología y Biología Vegetal.-- Primer Cursillo Nacional sobre Micromorfología de Suelos .-- Elecciones de representantes para la Comisión Científica del C. S. l. C.--Elecciones de representantes para la Comisión Económica del C. S. l. C.Peer reviewe

Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study

Background Population distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.Methods A sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) &gt;0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determination, 6 min walk test, routine blood analysis and low-dose CT scan with evaluation of lung density and airway wall thickness.Results In never, former and current smokers, prevalence of reduced DLCO was 6.7%, 14.4% and 26.7%, respectively. Current and former smokers with reduced DLCO without airflow limitation were younger than the subjects with normal DLCO, and they had greater levels of dyspnoea and exhaled CO, greater pulmonary artery diameter and lower spirometric parameters, 6 min walk distance, daily physical activity and plasma albumin levels (all p&lt;0.05), with no significant differences in other chronic respiratory symptoms or CT findings. FVC and exhaled CO were identified as independent risk factors for low DLCO.Conclusion Reduced DLCO is a frequent disorder among smokers without airflow limitation, associated with decreased exercise capacity and with CT findings suggesting that it may be a marker of smoking-induced early vascular damage.Trial registration number NCT03028207

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave : the global UNITE-COVID study

Purpose To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients. Methods Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020. Results 4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%-50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors. Conclusions ICUs responded to the increase in COVID-19 patients by increasing bed availability and staff, admitting up to 40% of patients in surge capacity beds. Although mortality in this population was high, admission to a surge capacity bed was not associated with increased mortality. Older age, invasive mechanical ventilation, and AKI were identified as the strongest predictors of mortality

Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set

Background: The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic conditions; however, data have suggested that patterns of these differ between COVID-19 and other viral pneumonitides. This secondary analysis aimed to explore patterns of co-infection and intensive care unit-acquired infections (ICU-AI) and the relationship to use of corticosteroids in a large, international cohort of critically ill COVID-19 patients.Methods: This is a multicenter, international, observational study, including adult patients with PCR-confirmed COVID-19 diagnosis admitted to ICUs at the peak of wave one of COVID-19 (February 15th to May 15th, 2020). Data collected included investigator-assessed co-infection at ICU admission, infection acquired in ICU, infection with multi-drug resistant organisms (MDRO) and antibiotic use. Frequencies were compared by Pearson's Chi-squared and continuous variables by Mann-Whitney U test. Propensity score matching for variables associated with ICU-acquired infection was undertaken using R library MatchIT using the "full" matching method.Results: Data were available from 4994 patients. Bacterial co-infection at admission was detected in 716 patients (14%), whilst 85% of patients received antibiotics at that stage. ICU-AI developed in 2715 (54%). The most common ICU-AI was bacterial pneumonia (44% of infections), whilst 9% of patients developed fungal pneumonia; 25% of infections involved MDRO. Patients developing infections in ICU had greater antimicrobial exposure than those without such infections. Incident density (ICU-AI per 1000 ICU days) was in considerable excess of reports from pre-pandemic surveillance. Corticosteroid use was heterogenous between ICUs. In univariate analysis, 58% of patients receiving corticosteroids and 43% of those not receiving steroids developed ICU-AI. Adjusting for potential confounders in the propensity-matched cohort, 71% of patients receiving corticosteroids developed ICU-AI vs 52% of those not receiving corticosteroids. Duration of corticosteroid therapy was also associated with development of ICU-AI and infection with an MDRO.Conclusions: In patients with severe COVID-19 in the first wave, co-infection at admission to ICU was relatively rare but antibiotic use was in substantial excess to that indication. ICU-AI were common and were significantly associated with use of corticosteroids