Epidemiologia molecular de Staphylococcus aureus no Brasil: elevada frequência de clones epidêmicos|pandêmicos, CA-MRSA e perspectivas futuras / Molecular epidemiology of Staphylococcus aureus in Brazil: high frequency of international epidemic|pandemic clones, CA-MRSA and perspectives

Staphylococcus aureus meticilina-resistente (MRSA) e meticilina-sensível (MSSA) são importantes patógenos nas infecções adquiridas na comunidade e nos hospitais no Brasil e em todo o mundo. O presente estudo tem como objetivo realizar uma revisão da literatura a respeito da epidemiologia molecular e resistência antimicrobiana de S. aureus à meticilina no Brasil e sua importância para Saúde Pública. Embora existam muitos artigos que investiguem a genômica de S. aureus, há relativamente poucos artigos que investigam os MRSA em escala genômica no país. A publicação mais antiga descreve a disseminação inter-hospitalar de um único clone MRSA em oito dos nove hospitais sob vigilância epidemiológica em São Paulo entre 1990 e 1992. Um ano depois, isolados MRSA provenientes de grandes hospitais universitários, presentes em diferentes regiões do Brasil, demonstraram o mesmo padrão de PFGE, indicando que um único clone, o clone epidêmico Brasileiro (BEC/ST239/CC8/SCCmecIII), estava disseminado no Brasil. Desde então, o BEC tem sido altamente prevalente nos hospitais do país, apresentando frequência acima de 50% em relação a todos os S. aureus isolados no Brasil. Embora o clone BEC seja o mais frequente, diversos estudos relatam um aumento expressivo na presença de clones como o USA400 (ST1/CC1/SCCmecIV) e o clone Pediátrico (USA800/ST5/CC5/SCCmecIV) em hospitais do Brasil, além da presença de outros clones como o USA100/New York/Japan (ST5-SCCmecII) e o clone USA1100/Southwest pacific clone (SWP) (ST30-SCCmecIV). Adicionalmente, a prevalência de MRSA em infecções adquiridas na comunidade (CA-MRSA) se encontra em ascensão. São necessários ainda mais estudos para que haja um maior conhecimento a respeito da epidemiologia molecular, virulência e resistência antimicrobiana de S. aureus à meticilina no Brasil, especialmente nas regiões Norte, Nordeste e Centro-Oeste do país, visto que a maioria dos estudos se concentram no eixo sul-sudeste, limitando a análise do perfil de S. aureus no país. 

The reference site collaborative network of the european innovation partnership on active and healthy ageing

Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs

The Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing.

International audienc

The Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing.

International audienceSeventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs

The reference site collaborative network of the european innovation partnership on active and healthy ageing

Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs

The Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing.

International audienceSeventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs