Identifying a black hole X-ray transient in M31 with XMM-Newton and Chandra

Stochastic variability in two out of four XMM-Newton observations of XMMU J004303+4115 along with its power spectra and X-ray luminosities suggest a low-mass X-ray binary (LMXB) with a black hole primary. However, Chandra observations resolve the object into two point sources. We use data from 35 Chandra observations to analyse the contributions of each source, and attribute the variability to CXOM31 J004303.2+411528 (known as r2-3), which varies in intensity by a factor of ~100 between observations. We assume that the power density spectra of LMXBs are governed by the luminosity, and that the transition between types of power density spectra occurs at some critical luminosity in Eddington units, l_c, that applies to all LMXBs. We use results from these XMM-Newton observations and past results from the available literature to estimate this transition luminosity, and find that all results are consistent with l_c ~0.1 in the 0.3--10 keV band. CXOM31 J004303.2+411528 exhibits a low accretion rate power density spectrum at a 0.3--10 keV luminosity of (5.3+/-0.6)x10^{37} erg/s. Known stellar mass black holes have masses of 4--15 M_{\odot}; hence our observations of CXOM31 J004303.2+411528 are consistent with l_c ~0.1 if it has a black hole primary.Comment: Accepted for publication in A&A; 9 pages, 4 figure

Opinion

Organ transplantation has evoked such mixed and even violent reaction that it would seem worthwhile to explore the ethics governing it — and to do this by examining the three major areas of contention: the act itself, the recipient and the donor.IS TRANSPLANTATION ETHICAL?News coverage of transplantation in the popular mass media has been widespread, enthusiastic and, unfortunately, too often sensational and misleading. I t has been misconceived in certain sections of the public both as a panacea and as an unethical and unjustified form of treatment. Neither assertion is accurate.Within our currently limited understanding of immunological attack on an allograft and our inability to prevent such an onslaught, the transplantation of any organ must be accepted as palliative therapy — not a final cure. It achieves palliation which equals, if it does not surpass, some forms of palliation which have been accepted for many years as the only way to deal with malignant diseases. This being established, one cannot accept as unjustifiable or unethical the palliation of symptoms and extension of life itself

Cathodoluminescence-based nanoscopic thermometry in a lanthanide-doped phosphor

Crucial to analyze phenomena as varied as plasmonic hot spots and the spread of cancer in living tissue, nanoscale thermometry is challenging: probes are usually larger than the sample under study, and contact techniques may alter the sample temperature itself. Many photostable nanomaterials whose luminescence is temperature-dependent, such as lanthanide-doped phosphors, have been shown to be good non-contact thermometric sensors when optically excited. Using such nanomaterials, in this work we accomplished the key milestone of enabling far-field thermometry with a spatial resolution that is not diffraction-limited at readout. We explore thermal effects on the cathodoluminescence of lanthanide-doped NaYF$_4$ nanoparticles. Whereas cathodoluminescence from such lanthanide-doped nanomaterials has been previously observed, here we use quantitative features of such emission for the first time towards an application beyond localization. We demonstrate a thermometry scheme that is based on cathodoluminescence lifetime changes as a function of temperature that achieves $\sim$ 30 mK sensitivity in sub-$\mu$m nanoparticle patches. The scheme is robust against spurious effects related to electron beam radiation damage and optical alignment fluctuations. We foresee the potential of single nanoparticles, of sheets of nanoparticles, and also of thin films of lanthanide-doped NaYF$_4$ to yield temperature information via cathodoluminescence changes when in the vicinity of a sample of interest; the phosphor may even protect the sample from direct contact to damaging electron beam radiation. Cathodoluminescence-based thermometry is thus a valuable novel tool towards temperature monitoring at the nanoscale, with broad applications including heat dissipation in miniaturized electronics and biological diagnostics.Comment: Main text: 30 pages + 4 figures; supplementary information: 22 pages + 8 figure

Insight into the Machinery and Applications for Understanding the Pathogen- Vector Interface

The availability of genome sequencing data in combination with knowledge of expressed genes via transcriptome and proteome data has greatly advanced our understanding of arthropod vectors of disease. Not only have we gained insight into vector biology, but also into their respective vector-pathogen interactions. By combining the strengths of postgenomic databases and reverse genetic approaches such as RNAi, the numbers of available drug and vaccine targets, as well as number of transgenes for subsequent transgenic or paratransgenic approaches, have expanded. These are now paving the way for in- field control strategies of vectors and their pathogens. Basic scientific questions, such as understanding the basic components of the vector RNAi machinery, is vital, as this allows for the transfer of basic RNAi machinery components into RNAi-deficient vectors, thereby expanding the genetic toolbox of these RNAi-deficient vectors and pathogens. In this review, we focus on the current knowledge of arthropod vector RNAi machinery and the impact of RNAi on understanding vector biology and vector-pathogen interactions for which vector genomic data is available on VectorBase

Physical changes during Z-track movement in Sco X-1 on the flaring branch

We present results of a detailed study of X-ray flaring in the Z-track source Sco X-1 in a highly super-Eddington state made using high quality Rossi-XTE data from the PCA and HEXTE instruments. The emission model successfully used to explain the dipping LMXB, and other classes of LMXB in recent years, was applied to study the physical evolution along the Z-track which remains a major problem. This model consists of blackbody emission from the neutron star plus Comptonized emission from an extended accretion disk corona. As found in earlier work, major changes take place in the neutron star blackbody emission with kT increasing in flaring, and the blackbody radius R_BB increasing substantially to a maximum value of 9.4 +/- 0.6 km, consistent with the radius of the neutron star, after which R_BB decreases. Thus this result is a measurement of neutron star radius. The behaviour of Sco X-1 in flaring is compared with our previous results for the strong flaring that takes place in the bright dipping, flaring LMXB X 1624-490. Remarkably, during movement along the Normal Branch towards the apex with the Flaring Branch, the luminosities of both spectral components decrease, suggesting the possibility that Mdot may decrease on the Normal Branch, contrary to the widely-held view that Mdot increases monotonically along the Z-track. During flaring, we detect for the first time an increase of the Comptonization cut-off energy which may suggest heating of the ADC plasma by the neutron star flare. The energy of a broad Gaussian line at 6.4 keV does not change, but the intensity of the line increases in flaring suggesting either an increase in ADC size in flaring or the effects of irradiation by the neutron star.Comment: 12 pages including 8 figures, Astronomy and Astrophysics in press; reference list correcte

Spectral analysis of LMC X-2 with XMM/Newton: unveiling the emission process in the extragalactic Z-source

We present the results of the analysis of an archival observation of LMC X-2 performed with XMM/Newton. The spectra taken by high-precision instruments have never been analyzed before. We find an X-ray position for the source that is inconsistent with the one obtained by ROSAT, but in agreement with the Einstein position and that of the optical counterpart. The correlated spectral and timing behaviour of the source suggests that the source is probably in the normal branch of its X-ray color-color diagram. The spectrum of the source can be fitted with a blackbody with a temperature 1.5 keV plus a disk blackbody at 0.8 keV. Photoelectric absorption from neutral matter has an equivalent hydrogen column of 4 x 10^{20} cm^{-2}. An emission line, which we identify as the O VIII Lyman alpha line, is detected, while no feature due to iron is detected in the spectrum. We argue that the emission of this source can be straightforwardly interpreted as a sum of the emission from a boundary layer between the NS and the disc and a blackbody component coming from the disc itself. Other canonical models that are used to fit Z-sources do not give a satisfactory fit to the data. The detection of the O VIII emission line (and the lack of detection of lines in the iron region) can be due to the fact that the source lies in the Large Magellanic Cloud.Comment: Accepted for publication by Astronomy & Astrophysic

Investigations of a Gandharan stucco head of the Buddha at the Victoria and Albert Museum (IM.3-1931)

This study presents the results of a technical and art historical study of an important Gandharan head from the Victoria and Albert Museum. For several years, the head has played an important role in the history of Gandharan art, because of its high aesthetic qualities. However, the head has received limited scholarly attention since its first display in the 1930s. This study reviewed the head’s physical, curatorial and conservation history and determined its construction using non-invasive and non-contact investigative techniques (technical imaging, FTIR, XRF and FORS). The support consists of several layers of a lime- and gypsum-based plaster (gauging plaster) and only salient elements of the face (e.g. lips, eyes and hairline) and the hair were painted, with a high-quality red ochre and with an unidentified black pigment, respectively. A careful examination of the construction of the head allowed to determine that it probably belonged to an iconic representation of the Buddha, as opposed to a narrative scene

Local sensing of absolute refractive index during protein-binding using microlasers with spectral encoding

Funding: Engineering and Physical Sciences Research Council - EP/P030017/1; Alexander von Humboldt-Stiftung; European Research Council - 640012; Royal Society - DH160102.Multiplexed, specific, and sensitive detection of antigens is critical for the rapid and accurate diagnosis of disease and the informed development of personalized treatment plans. Here, it is shown that polymer microsphere lasers can be used as photonic sensors to monitor and quantify direct surface binding of biomolecules via changes in the refractive index. The unique spectral signature of each individual laser can be used to find their size and effective refractive index which adds a new encoding dimension when compared to conventional fluorescent beads. Antibody-functionalized microlasers selectively detect protein binding, as demonstrated for Immunoglobulin G and C-reactive protein, and have the ability to resolve different stages of the multilayer surface modification. Moreover, by continuously monitoring single lasers, the possibility of real-time monitoring of binding dynamics between antigens in solution phase and the immobilized antibodies is demonstrated. For multiplexed detection, the microlasers are employed in a flow cytometer configuration, with fast spectral detection and identification of microlasers with and without antigen binding. It is envisioned that by combining microlasers with well-established surface modification chemistries and flow geometries, the multiplexing ability of microbead immunoassays can be strongly increased while also opening avenues for single-cell profiling within heterogeneous cell populations.Publisher PDFPeer reviewe