Influence of parental compliance on the effectiveness of treatment of chronic gastroduodenal pathology in children

The article focuses on the studies which point to particular difficulties in achieving compliance in pediatrics. A dangerous trend to escalate the number and doses of antibiotics in anti- Helicobacter pylori (HP) schemes, the dosage frequency and course duration of eradication therapy considerably complicates a patient’s compliance to the treatment and contributes to a further growth of HP antibiotic resistance. In the treatment of children, the control of the outpatient therapy largely depends on the patient’s parent

Monitoring and phytoremediation of contaminated with heavy metals soils

This work contains a monitoring 4 spring ecosystems varying degrees of anthropogenic impact, as indicators of the quality of the environment by vegetation appraisal and analysis of the content of heavy metals in it. It is istablished the relationship between the state of natural plant communities, changes in the properties of the soil, the quality of spring water and the level of anthropogenic impact on these ecosystems. It is offered promising plant accumulators of heavy metalsПредставлен мониторинг 4-х родниковых экосистем с различной степенью техногенного воздействия, как индикаторов качества состояния окружающей среды посредством бонитировки растительности и анализа содержания в ней тяжелых металлов. Установлена взаимосвязь между состоянием природных растительных сообществ, изменением свойств почвы, качеством родниковой воды и уровнем техногенной нагрузки на эти экосистемы. Предложены перспективные растения-аккумуляторы тяжелых металло

Carboxylic acid as amplifiers soil cleaning process plants via

The work is devoted to prommotriruyuschego effect of organic fatty acids on the migratory ability of lead and cadmium in the system "soil-plant"Работа посвящена исследованию проммотрирующего влияния органических кислот жирного ряда на миграционные способности свинца и кадмия в системе «почва-растение

Interleukin-18 gene polymorphism in pregnancy With premature rupture of membranes: A case-control study

Background. Imbalanced pro- and anti-inflammatory systems can unfavourably condition carrying of pregnancy and provoke gestation complications, such as premature rupture of membranes.Objectives. Assessing the contribution of SNP variants -137G>C (rs187238), -607G>T (rs1946518) and -656A>C (rs5744228) of the IL-18 gene promoter to the incidence of extremely preterm premature rupture of membranes.Methods. A case-control study enrolled 120 pregnant women managed at the Perinatal Centre. The women were divided in two cohorts. The study cohort comprised 80 women with premature rupture of membranes at 22–27 weeks 6 days’ gestation hospitalised in a high-risk pregnancy unit, a control cohort consisted of 40 women with physiological pregnancy at 22–27 weeks 6 days’ gestation following outpatient counselling. The cohorts had comparable obstetric and gynaecological histories. The study exclusion criteria were: multiple gestation, foetal chromosomal anomalies, congenital foetal malformations, pregnancy due to assisted reproduction. Genotyping was performed at positions -137G>C, -607G>T and -656A>C of the IL-18 gene promoter with determining a peripheral blood IL-18 level in cohorts.Results. The premature rupture of membranes cohort had a statistically higher serum interleukin-18 concentration compared to control (p = 0.001). Genotyping of the IL-18 gene promoter revealed a statistically higher rate of homozygous -137G>C mutation (CC genotype) in the premature rupture of membranes cohort at 22–27 weeks 6 days’ term (p <0.001), 67 vs. 27% in control.Conclusion. A homozygous IL-18 -137G>C polymorphic variant associated with elevated blood IL-18 levels is statistically more common in pregnant women having premature rupture of membranes at 22–27 weeks 6 days’ gestation

Observation of Cosmic Gamma Ray Bursts in the Experiments Onboard Lomonosov and Vernov Satellites

Abstract: The study of cosmic gamma ray bursts (GRBs) is one of the main goals of the Lomonosov space mission. The main advantage of this mission is simultaneous multiwavelength observations of GRBs covering the optical, X-ray and gamma-ray ranges. The mission payload includes the GRB monitor BDRG, wide-field optical cameras SHOK, and the UFFO instrument. Data are recorded mainly by the event trigger provided by the BDRG instrument, which measures the spectral and temporal properties of the burst in the energy range 10–3000 keV. The BDRG instrument also provides estimation of the source coordinates by comparing the readings of three differently directed detectors with an accuracy of several degrees. Wide-field SHOK optical cameras have a field of view of ~20° × 40°. They fix a set of images with a frequency of about five frames per second prior to the trigger and another set immediately after the trigger. The UFFO instrument includes the UBAT telescope with a coded mask for measurements in hard X-ray and soft gamma-ray ranges and an optical telescope with a slewing mirror (SMT) that can be directed on the GRB source for a time ~1 s for measuring GRB prompt emission in the early stages. In response to an BDRG trigger signal, the real-time data on a detected GRB are transmitted to the Earth via Globalstar network to the Gamma-ray Coordinates Network (GCN) and ground-based observatories. During observations on the Lomonosov satellite, 20 gamma-ray bursts were detected and catalogued. Several gamma-ray bursts were also detected in the Vernov satellite experiment. An example of such an event is given.Financial support for this work was provided by the Ministry of Education and Science of the Russian Federation, project no RFMEFI60717X0175

Cleaning of aquatic ecosystems from oil new effective sorbent

Is devoted to the production of particles of amorphous silica, the study of the nature of the interaction of the silica nanoparticles with surfactants to the water surface and the assessment of their absorption capacity in relation to petroleum productsРабота посвящена получению частиц аморфного кремнезема, исследованию природы взаимодействия наночастиц кремнезема с поверхностно-активными веществами на водных поверхностях и оценка их адсорбционной способности по отношению к нефтепродукта

Risk factors for in vitro fertilization failures in women with adenomyosis-associated infertility

Aim. To identify risk factors for in vitro fertilization (IVF) failures in women with adenomyosis-associated infertility. Materials and methods. The study included 83 patients of reproductive age with adenomyosis. Women were divided into two groups: the main group (n=53) included patients with adenomyosis and a history of 1 or more unsuccessful attempts at embryo transfer, and the comparison group (n=30) included women with adenomyosis without impaired fertile function. The mean age of the patients was 364.0 years. Results. Gynecological conditions such as cervical dysplasia, noninflammatory vaginal diseases, and a history of sexually transmitted infections (STIs) were significantly (5-fold) more common in patients with a history of IVF failures (p0.05). A high prevalence of endocrine and digestive system disorders (27.7 and 7.7 times, respectively) was found in infertile women with adenomyosis (p0.05). Coagulation disorders were identified 4.8 times more often in women with adenomyosis-associated infertility and IVF failures. Inflammatory and proliferative endometrial diseases (hyperplasia, intrauterine synechia, and chronic endometritis) were significantly more common in patients in the main group than in patients with adenomyosis without impaired fertility (p0.05). Conclusion. Risk factors for IVF failure in women with adenomyosis-associated infertility are other specified coagulation defects [D68.8] (antiphospholipid syndrome), odds ratio (OR) 4.8, 95% confidence interval (CI) 1.120.9; dysplasia of cervix uteri, unspecified [N87.9] (OR 10.2, 95% CI 1.292.4), other noninflammatory disorders of vagina [N89.7] (OR 10.2, 95% CI 1.292.4), STIs (OR 12.7, 95% CI 1.4112.5), endocrine system disorders (OR 27.7, 95% CI 1.5516.5), and digestive system disorders (OR 7.8, 95% CI 2.227.8)

Cross-species amplification of 41 microsatellites in European cyprinids: A tool for evolutionary, population genetics and hybridization studies

<p>Abstract</p> <p>Background</p> <p>Cyprinids display the most abundant and widespread species among the European freshwater Teleostei and are known to hybridize quite commonly. Nevertheless, a limited number of markers for conducting comparative differentiation, evolutionary and hybridization dynamics studies are available to date.</p> <p>Findings</p> <p>Five multiplex PCR sets were optimized in order to assay 41 cyprinid-specific polymorphic microsatellite loci (including 10 novel loci isolated from <it>Chondrostoma nasus nasus, Chondrostoma toxostoma toxostoma </it>and <it>Leuciscus leuciscus</it>) for 503 individuals (440 purebred specimens and 63 hybrids) from 15 European cyprinid species. The level of genetic diversity was assessed in <it>Alburnus alburnus, Alburnoides bipunctatus, C. genei, C. n. nasus, C. soetta, C. t. toxostoma, L. idus, L. leuciscus, Pachychilon pictum, Rutilus rutilus, Squalius cephalus </it>and <it>Telestes souffia</it>. The applicability of the markers was also tested on <it>Abramis brama, Blicca bjoerkna </it>and <it>Scardinius erythrophtalmus </it>specimens. Overall, between 24 and 37 of these markers revealed polymorphic for the investigated species and 23 markers amplified for all the 15 European cyprinid species.</p> <p>Conclusions</p> <p>The developed set of markers demonstrated its performance in discriminating European cyprinid species. Furthermore, it allowed detecting and characterizing hybrid individuals. These microsatellites will therefore be useful to perform comparative evolutionary and population genetics studies dealing with European cyprinids, what is of particular interest in conservation issues and constitutes a tool of choice to conduct hybridization studies.</p