Introduction to the 'IIOAB Letters'

The Institute of Integrative Omics and Applied Biotechnology (IIOAB), India (www.iioab.webs.com / www.iioab.ac.in) is a non-profit scientific organization that aims to provide a global platform for multidisciplinary research and advocacy. Other aspects of the organization are promotion of higher education, R&D, and to serve science, society, and the mankind. To fulfil its mission, IIOAB is now introducing a new open access, preer-reviewed, scientific international journal- the “IIOAB Letters” that will publish articles covering all aspects of biological sciences.  The journal is dedicated to students, who are our future, and will provide a platform to all scientific community to publish their articles.The journal is a collaborative effore of IIOAB and University Library Sysltem (ULS), Office of Scholarly Communication, Publishing and Web Services from University of Pittsburgh, USA. for puting their all valuable efforts in successfully launch the journal using Open Journal System (OJS).The journal will publish basic and applied research articles, invited review articles, interviews, letters, reports etc. This journal will also provide a global forum for ethical and business knowledge exchange through publishing papers from all over the world. Another aspect of the journal is rapid review and fast publication.  The journal will be indexed in well known indexing agencies soon.As an open access journal, the journal will be highly dynamic and interactive and all article will be available freely immediately after publication. Therefore, all published article will be visible to researchers, teachers, students, and scientific community and industry people without delay.We are simply convinced that this is the right time for introduction of this new journal and we are confident that the IIAOB Letters will be a very successful new launch and will be essential to all scientific community.  Comments, suggestions and criticisms are always welcome.Success of any journal depends on strong international and dedicated Editorial Board and fortunately, we have a respectable board consisting of highly qualified personalities from multidisciplinary Biological Science background and from across the geographal regions. During the end of this year, IIOAB Letters also will invite distinguished members for Editorial Board expansion. In the near future our efforts will be focused to increase the publication of high quality research papers and to get a good impact factor as soon as possible. The Institute of Integrative Omics and Applied Biotechnology (IIOAB), India (www.iioab.webs.com / www.iioab.ac.in) is a non-profit scientific organization that aims to provide a global platform for multidisciplinary research and advocacy. Other aspects of the organization are promotion of higher education, R&D, and to serve science, society, and the mankind. To fulfil its mission, IIOAB is now introducing a new open access, preer-reviewed, scientific international journal- the “IIOAB Letters” that will publish articles covering all aspects of biological sciences.  The journal is dedicated to students, who are our future, and will provide a platform to all scientific community to publish their articles. The journal is a collaborative effore of IIOAB and University Library Sysltem (ULS), Office of Scholarly Communication, Publishing and Web Services from University of Pittsburgh, USA. for puting their all valuable efforts in successfully launch the journal using Open Journal System (OJS). The journal will publish basic and applied research articles, invited review articles, interviews, letters, reports etc. This journal will also provide a global forum for ethical and business knowledge exchange through publishing papers from all over the world. Another aspect of the journal is rapid review and fast publication.  The journal will be indexed in well known indexing agencies soon.As an open access journal, the journal will be highly dynamic and interactive and all article will be available freely immediately after publication. Therefore, all published article will be visible to researchers, teachers, students, and scientific community and industry people without delay.  We are simply convinced that this is the right time for introduction of this new journal and we are confident that the IIAOB Letters will be a very successful new launch and will be essential to all scientific community.  Comments, suggestions and criticisms are always welcome. Success of any journal depends on strong international and dedicated Editorial Board and fortunately, we have a respectable board consisting of highly qualified personalities from multidisciplinary Biological Science background and from across the geographal regions. During the end of this year, IIOAB Letters also will invite distinguished members for Editorial Board expansion. In the near future our efforts will be focused to increase the publication of high quality research papers and to get a good impact factor as soon as possible

Genomic Target Database (GTD): A database of potential targets in human pathogenic bacteria

A Genomic Target Database (GTD) has been developed having putative genomic drug targets for human bacterial pathogens. The selected pathogens are either drug resistant or vaccines are yet to be developed against them. The drug targets have been identified using subtractive genomics approaches and these are subsequently classified into Drug targets in pathogen specific unique metabolic pathways,Drug targets in host-pathogen common metabolic pathways, andMembrane localized drug targets. HTML code is used to link each target to its various properties and other available public resources. Essential resources and tools for subtractive genomic analysis, sub-cellular localization, vaccine and drug designing are also mentioned. To the best of authors knowledge, no such database (DB) is presently available that has listed metabolic pathways and membrane specific genomic drug targets based on subtractive genomics. Listed targets in GTD are readily available resource in developing drug and vaccine against the respective pathogen, its subtypes, and other family members. Currently GTD contains 58 drug targets for four pathogens. Shortly, drug targets for six more pathogens will be listed

Plastic fiber design for THz generation through wavelength translation

We report on an all-fiber Terahertz (THz) radiation source by exploiting nonlinear parametric process in a theoretically designed microstructured-core double clad plastic fiber (MC-DCPF). The required phase-matching condition is satisfied through suitable tailoring of the fiber dispersion and nonlinear properties at the pump wavelength of a high power CO2 laser, with a CO laser of much lower power acting as a seed concomitantly. Our simulated results reveal that a THz radiation source at the frequency of ~ 3 THz could be realized with a 3-dB phase-matching band-width of 2.13 GHz in a 65 m long optimized MC-DCPF. Maximum power conversion efficiency >1% is realizable even after including the material loss

Prevalence of Intestinal Helminthes among Children in Selected Communities in Monrovia, Liberia

The present study was carried out among children below 15 years in 10 communities in Monrovia. Out of the 646 children recruited in the study, 216 (33.4%) were positive for at least one intestinal helminth parasite. Children between 11 – 15 years had the highest prevalence of intestinal helminthes. Ascaris lumbricoides was the most common intestinal helminth parasite encountered (79.6%), followed by Trichuris trichura (19.0%). Strongyloides stercoralis and Enterobius vermicularis were the least prevalent helminth parasites encountered among the study population (1% each). The population in these communities depended largely on poorly built latrines and buckets for faecal disposal although some (49%) used flush toilets despite their being in poor conditions. Only 23.45 of the 646 children surveyed used pipe borne water for drinking and other domestic purposes. The high prevalence rates of helminth infection obtained could be due to persistent infection and re-infection of the study population as a result of the constant seeding of the soil with parasite eggs and larvae in these communities. Keywords: Prevalence, Intestinal helminth, Children, Liberi

Microrna let-7: an emerging next-generation cancer therapeutic

In recent years, various rna-based technologies have been under evaluation as potential next-generation cancer therapeutics. Micrornas (mirnas), known to regulate the cell cycle and development, are deregulated in various cancers. Thus, they might serve as good targets or candidates in an exploration of anticancer therapeutics. One attractive candidate for this purpose is let-7 (“lethal-7”)