The Islamic State as an empire of nostalgia

Primary empires were the product of internal development and self-sustaining through the exploitation of their own resources, but there were also historically a large number of “shadow empires.” These were imperial polities that were the products of secondary empire formation, which came into existence as a response to the formation of primary empires elsewhere and could not exist except in interaction with them. One unusual subset of these were “empires of nostalgia” that claimed an imperial tradition and the outward trappings of an extinct empire, but did not themselves meet the basic requirements of an imperial state such as direct control of territory, true centralized rule, or significant urban centers. The most famous European example was the Carolingian Empire established by Charlemagne and its long lived successor, the Holy Roman Empire, which survived as an institution for a thousand years. The Islamic State’s proclamation of itself as a reborn caliphate is now a contemporary example built on nostalgia in the Islamic world for a long-dead empire that still exerts a strong cultural attraction upon many Muslims. The Islamic State justifies its actions and ideologies by attempting to ground them in a lost golden age that they propose to restore

Bringing multilateralism back in: ending the war in Afghanistan is not a one-nation job

The United States’ unilateral deal with the Taliban in February 2020 needs to be expanded if it is to achieve success. Because the war in Afghanistan was never purely a domestic one, only a multilateral international agreement can end it and simultaneously empower Afghan stakeholders to determine their country’s future governance. A dual-track United Nations-led mediation platform, bolstered by a collaboration between Washington and Brussels, offers the best means to achieve this end. At the international and regional level, its goal would be conflict management: to end outside support for any faction unwilling to take part in the domestic peace process and to pledge support for any final negotiated peace agreement acceptable to a majority of the Afghan people. Since neither the Afghan government nor the Taliban can win a war or dictate the structure of a future constitutional order without such outside support, this would lay the groundwork for lasting conflict resolution within Afghanistan itself.Published versio

The Islamic State as an Empire of Nostalgia

Primary empires were the product of internal development and self-sustaining through the exploitation of their own resources, but there were also historically a large number of “shadow empires.” These were imperial polities that were the products of secondary empire formation, which came into existence as a response to the formation of primary empires elsewhere and could not exist except in interaction with them. One unusual subset of these were “empires of nostalgia” that claimed an imperial tradition and the outward trappings of an extinct empire, but did not themselves meet the basic requirements of an imperial state such as direct control of territory, true centralized rule, or significant urban centers. The most famous European example was the Carolingian Empire established by Charlemagne and its long lived successor, the Holy Roman Empire, which survived as an institution for a thousand years. The Islamic State’s proclamation of itself as a reborn caliphate is now a contemporary example built on nostalgia in the Islamic world for a long-dead empire that still exerts a strong cultural attraction upon many Muslims. The Islamic State justifies its actions and ideologies by attempting to ground them in a lost golden age that they propose to restore

Mother-offspring recognition via contact calls in cattle, Bos taurus.

Individual recognition in gregarious species is fundamental in order to avoid misdirected parental investment. In ungulates, two very different parental care strategies have been identified: ‘hider’ offspring usually lie concealed in vegetation whereas offspring of ‘follower’ species remain with their mothers while they forage. These two strategies have been suggested to impact on mother-offspring vocal recognition, with unidirectional recognition of the mother by offspring occurring in hiders and bidirectional recognition in followers. In domestic cattle, Bos taurus, a facultative hider species, vocal communication and recognition have not been studied in detail under free-ranging conditions, where cows and calves can graze freely and where hiding behaviour can occur. We hypothesized that, as a hider species, cattle under these circumstances would display unidirectional vocal recognition. To test this hypothesis, we conducted playback experiments using mother-offspring contact calls. We found that cows were more likely to respond, by moving their ears and/or looking, turning or walking towards the loudspeaker, to calls of their own calves than to calls from other calves. Similarly, calves responded more rapidly, and were more likely to move their ears and/or look, turn or walk towards the loudspeaker, and to call back and/or meet their mothers, in response to calls from their own mothers than to calls from other females. Contrary to our predictions, our results suggest that mother-offspring vocal individual recognition is bidirectional in cattle. Additionally, mothers of younger calves tended to respond more strongly to playbacks than mothers of older calves. Therefore, mother responses to calf vocalizations are at least partially influenced by calf age

Association between germline variants and somatic mutations in colorectal cancer

Colorectal cancer (CRC) is a heterogeneous disease with evidence of distinct tumor types that develop through different somatically altered pathways. To better understand the impact of the host genome on somatically mutated genes and pathways, we assessed associations of germline variations with somatic events via two complementary approaches. We first analyzed the association between individual germline genetic variants and the presence of non-silent somatic mutations in genes in 1375 CRC cases with genome-wide SNPs data and a tumor sequencing panel targeting 205 genes. In the second analysis, we tested if germline variants located within previously identified regions of somatic allelic imbalance were associated with overall CRC risk using summary statistics from a recent large scale GWAS (n similar or equal to 125 k CRC cases and controls). The first analysis revealed that a variant (rs78963230) located within a CNA region associated with TLR3 was also associated with a non-silent mutation within gene FBXW7. In the secondary analysis, the variant rs2302274 located in CDX1/PDGFRB frequently gained/lost in colorectal tumors was associated with overall CRC risk (OR = 0.96, p = 7.50e-7). In summary, we demonstrate that an integrative analysis of somatic and germline variation can lead to new insights about CRC