Self-injurious Behavior of Children with Autism in Vietnam: Across Sectional Study

This study explored self-injurious behaviour (SIB) of autistic children in Vietnam through a crosssectional design. 60 informants, including 57 parents and 3 caregivers completed the questionnaire on problem behaviour consisting of aggression, self-injury, stereotyping, property destruction, other problem behaviours and their functions. Results revealed that children experienced all mentioned problem behaviours, especially self-injurious behaviour. The topographies of self-injurious behaviour of the children included head-hitting, head-scratching, head-banging, hair-pulling, face-hitting, facepuncturing with a pen, ear-scratching, lip-picking, hand-biting, hand-scratching, hand-pinching, and belly-scratching. The most common area of self-injurious behaviour is the head. The functions of these problem behaviours were expressed in four types (social positive reinforcement, social negative reinforcement, automatic positive reinforcement and automatic negative reinforcement). Social positive reinforcement appeared as a prominent function. Out of these 57 children, 21 of them who were autistic with self-injurious behaviour went through a functional behaviour assessment (FBA) in which the four conditions known as attention, tangible items, escape from task/activities, automatic stimulation were tested. The results of functional behaviour assessment (FBA) further indicated the correspondence between the FAST-R and FBA outcome on function of problem behaviour, especially self-injurious behaviour. The research concluded that the prominent function of these self-injurious behaviours was social function. It means self-injurious behaviours usually occur within a condition of social interaction, especially, in this present study, in the tangible condition. The antecedent of selfinjurious behaviour is the removal of tangibles (e.g. food, preferred items). This paper contributes to our knowledge of self-injurious behaviour of children with autism in Vietnam where empirical research of this field was still very rare

The role of entrepreneurship orientation in forming students' entrepreneurial intention through entrepreneurial education

Entrepreneurship is a global phenomenon because it contributes to economic growth, maintenance of social stability, and reduced unemployment. However, the role of entrepreneurial orientation in Vietnamese universities remains blurred. This study aims to understand the role of university education in shaping the entrepreneurial intention of Vietnamese students through entrepreneurial orientation, perceived desirability, and perceived feasibility. The PLS-SEM technique with SmartPLS 4 software tested the research model and hypotheses. The data set was collected from May 2023 to June 2023 via Google Forms with 411 respondents. The results show that entrepreneurial education has the most decisive impact on perceived desirability, followed by perceived feasibility, and both of these factors have a substantial impact on entrepreneurial orientation and entrepreneurial intention. Based on the results, the research has suggested practical implications that enhance entrepreneurial intention and promote the development of Vietnam's economy

Long short-term memory (LSTM) neural networks for short-term water level prediction in Mekong river estuaries

This study firstly adopts a state-of-the-art deep learning approach based on a Long Short-Term Memory (LSTM) neural network for predicting the hourly water level of Mekong estuaries in Vietnam. The LSTM models were developed from around 8,760 hourly data points within 2018 and were evaluated using the Nash-Sutcliffe efficiency coefficient (NSE), mean absolute error (MAE), and root mean square error (RMSE). The results showed that the NSE values for the training and testing steps were both above 0.98, which can be regarded as very good performance. Furthermore, the RMSE were between 0.09 and 0.11 m for the training and between 0.10 and 0.12 m for the testing, while MAE for the training ranged from 0.07 to 0.08 m and varied from 0.08 to 0.10 m for the testing. The LSTM networks appear to enable high precision and robustness in water level time series prediction. The outcomes of this research have crucial implications in river water level predictions, especially from the viewpoint of employing deep learning algorithms

Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study.

Antibiotic tolerance in Mycobacterium tuberculosis leads to less effective bacterial killing, poor treatment responses and resistant emergence. There is limited understanding of antibiotic tolerance in clinical isolates of M. tuberculosis . Therefore, we investigated the rifampicin tolerance of M. tuberculosis isolates, with or without pre-existing isoniazid-resistance. In-vitro rifampicin survival fractions determined by minimum duration of killing assay in isoniazid susceptible (n=119) and resistant (n=84) M. tuberculosis isolates. Rifampicin tolerance was correlated with bacterial growth, rifampicin minimum inhibitory concentrations (MICs) and isoniazid-resistant mutations. The longitudinal isoniazid-resistant isolates were analyzed for rifampicin tolerance based on collection time from patients and associated emergence of genetic variants. The median duration of rifampicin exposure reducing the M. tuberculosis surviving fraction by 90% (minimum duration of killing-MDK90) increased from 1.23 (95%CI 1.11; 1.37) and 1.31 (95%CI 1.14; 1.48) to 2.55 (95%CI 2.04; 2.97) and 1.98 (95%CI 1.69; 2.56) days, for IS and IR respectively, during 15 to 60 days of incubation respectively. Increase in MDK90 time indicated the presence of fast and slow growing tolerant sub-populations. A range of 6 log 10 -fold survival fraction enabled classification of tolerance as low, medium or high and revealed isoniazid-resistance association with increased tolerance with faster growth (OR=2.68 for low vs. medium, OR=4.42 for low vs. high, P -trend=0.0003). The high tolerance in longitudinal isoniazid-resistant isolates was specific to those collected during rifampicin treatment in patients and associated with bacterial genetic microvariants. Our study identifies a range of rifampicin tolerance and reveals that isoniazid resistance is associated with higher tolerance with growth fitness. Furthermore, rifampicin treatment may select isoniazid-resistant isolate microvariants with higher rifampicin tolerance, with survival potential similar to multi-drug resistant isolates. These findings suggest that isoniazid-resistant tuberculosis needs to be evaluated for rifampicin tolerance or needs further improvement in treatment regimen

Evaluation of awake prone positioning effectiveness in moderate to severe COVID-19

Evidence mainly from high income countries suggests that lying in the prone position may be beneficial in patients with COVID-19 even if they are not receiving invasive ventilation. Studies indicate that increased duration of prone position may be associated with improved outcomes, but achieving this requires additional staff time and resources. Our study aims to support prolonged (≥ 8hours/day) awake prone positioning in patients with moderate to severe COVID-19 disease in Vietnam. We use a specialist team to support prone positioning of patients and wearable devices to assist monitoring vital signs and prone position and an electronic data registry to capture routine clinical data

Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study

Antibiotic tolerance in Mycobacterium tuberculosis reduces bacterial killing, worsens treatment outcomes, and contributes to resistance. We studied rifampicin tolerance in isolates with or without isoniazid resistance (IR). Using a minimum duration of killing assay, we measured rifampicin survival in isoniazid-susceptible (IS, n=119) and resistant (IR, n=84) isolates, correlating tolerance with bacterial growth, rifampicin minimum inhibitory concentrations (MICs), and isoniazid-resistant mutations. Longitudinal IR isolates were analyzed for changes in rifampicin tolerance and genetic variant emergence. The median time for rifampicin to reduce the bacterial population by 90% (MDK90) increased from 1.23 days (IS) and 1.31 days (IR) to 2.55 days (IS) and 1.98 days (IR) over 15–60 days of incubation, indicating fast and slow-growing tolerant sub-populations. A 6 log10-fold survival fraction classified tolerance as low, medium, or high, showing that IR is linked to increased tolerance and faster growth (OR = 2.68 for low vs. medium, OR = 4.42 for low vs. high, p-trend = 0.0003). High tolerance in IR isolates was associated with rifampicin treatment in patients and genetic microvariants. These findings suggest that IR tuberculosis should be assessed for high rifampicin tolerance to optimize treatment and prevent the development of multi-drug-resistant tuberculosis

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Research Influence of Flux Air Gaps on Electromagetic Components of Shunt Reactors

This paper introduces an evaluation of the flux air gaps of Shunt Reactors (SRs) to effectively mitigate fringing and leakage fluxes along the height of the iron core. The assessment of these discretely distributed flux air gaps in SRs is a rigorous and challenging process. To define their exact number, the case of one flux air gap is analyzed and investigated to observe/simulate the influence of the flux density distribution and the leakage flux along the air gaps on the reactive power and the operation conditions of the SR. Based on that, to reduce leakage flux, a large flux air gap is divided into smaller ones. Initially, an analytic model is presented to define the main parameters of the SRs. Then, a finite element method is developed to simulate electromagnetic quantities, such as the magnetic flux density, leakage flux, and electromagnetic force. The obtained results can help manufacturers define the exact number of flux air gaps along the iron core of the SR. From that, a suitable technology can be given in manufacturing high voltage SRs applied to high or super high voltage transmission lines