The Detection of an Extremely Bright Fast Radio Burst in a Phased Array Feed Survey

We report the detection of an ultra-bright fast radio burst (FRB) from a modest, 3.4-day pilot survey with the Australian Square Kilometre Array Pathfinder. The survey was conducted in a wide-field fly's-eye configuration using the phased-array-feed technology deployed on the array to instantaneously observe an effective area of 160 deg^2, and achieve an exposure totaling 13200 deg^2 hr. We constrain the position of FRB 170107 to a region 8^'x 8^' in size (90% containment) and its fluence to be 58 ± 6 Jy ms. The spectrum of the burst shows a sharp cutoff above 1400 MHz, which could be due to either scintillation or an intrinsic feature of the burst. This confirms the existence of an ultra-bright (> 20 Jy ms) population of FRBs

Ensemble prediction for nowcasting with a convection-permitting model - II: forecast error statistics

A 24-member ensemble of 1-h high-resolution forecasts over the Southern United Kingdom is used to study short-range forecast error statistics. The initial conditions are found from perturbations from an ensemble transform Kalman filter. Forecasts from this system are assumed to lie within the bounds of forecast error of an operational forecast system. Although noisy, this system is capable of producing physically reasonable statistics which are analysed and compared to statistics implied from a variational assimilation system. The variances for temperature errors for instance show structures that reflect convective activity. Some variables, notably potential temperature and specific humidity perturbations, have autocorrelation functions that deviate from 3-D isotropy at the convective-scale (horizontal scales less than 10 km). Other variables, notably the velocity potential for horizontal divergence perturbations, maintain 3-D isotropy at all scales. Geostrophic and hydrostatic balances are studied by examining correlations between terms in the divergence and vertical momentum equations respectively. Both balances are found to decay as the horizontal scale decreases. It is estimated that geostrophic balance becomes less important at scales smaller than 75 km, and hydrostatic balance becomes less important at scales smaller than 35 km, although more work is required to validate these findings. The implications of these results for high-resolution data assimilation are discussed

Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence

Original Research ArticleIntroduction. This pilot study evaluated the expression of the proinflammatory cytokine IL-17 along the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence by establishing the expression levels of IL-17 in columnar epithelium, intestinal metaplastic cells, and dysplastic/glandular neoplastic cells. Immunohistochemical techniques were used to examine the accumulation of the proinflammatory cytokine IL-17 in forty () formalin-fixed, paraffin-embedded oesophageal archived specimens across a range of endoscopic diagnostic categories, and a highly significant difference was found, where , in IL-17 expression (Kruskall Wallis and Mann-Whitney ) between all the cell types examined. There was also a strong positive correlation (Spearman's rank correlation) between disease progression and IL-17 expression (, , ), IL-17 expression was absent or absent/weak in columnar epithelium, weak to moderate in columnar metaplastic cells, and moderate to strong in dysplastic/neoplastic cells, which demonstrated that the elevation of IL-17 expression occurs in the progression of the disease. Understanding the differential expression of IL-17 between benign and malignant tissue potentially has a significant diagnostic, prognostic, and therapeutic value. Ultimately, this selective biomarker may be employed in routine clinical practice for the screening of oesophageal adenocarcinoma.The authors thankfully acknowledge the University of Chester for their financial support

Faraday Rotation in the Tail of the Planetary Nebula DeHt 5

We present 1420 MHz polarization images of a 5x5 degree region around the planetary nebula (PN) DeHt 5. The images reveal narrow Faraday-rotation structures on the visible disk of DeHt 5, as well as two wider, tail-like, structures "behind" DeHt 5. Though DeHt 5 is an old PN known to be interacting with the interstellar medium (ISM), a tail has not previously been identified for this object. The innermost tail is approximately 3 pc long and runs away from the north-east edge of DeHt 5 in a direction roughly opposite that of the sky-projected space velocity of the white dwarf central star, WD 2218+706. We believe this tail to be the signature of ionized material ram-pressure stripped and deposited downstream during a >74,000 yr interaction between DeHt 5 and the ISM. We estimate the rotation measure (RM) through the inner tail to be -15 +/- 5 rad/m^2, and, using a realistic estimate for the line-of-sight component of the ISM magnetic field around DeHt 5, derive an electron density in the inner tail of n_e = 3.6 +/- 1.8 cm^-3. Assuming the material is fully ionized, we estimate a total mass in the inner tail of 0.68 +/- 0.33 solar masses, and predict that 0.49 +/- 0.33 solar masses was added during the PN-ISM interaction. The outermost tail consists of a series of three roughly circular components, which have a collective length of approximately 11.0 pc. This tail is less conspicuous than the inner tail, and may be the signature of the earlier interaction between the WD 2218+706 asymptotic giant branch (AGB) progenitor and the ISM. The results for the inner and outer tails are consistent with hydrodynamic simulations, and may have implications for the PN missing-mass problem as well as for models which describe the impact of the deaths of intermediate-mass stars on the ISM.Comment: 30 pages (single-column preprint format), 5 figures. Accepted for publication in the Astrophysical Journa

Single nucleotide polymorphisms reveal a genetic cline across the north-east Atlantic and enable powerful population assignment in the European lobster

This is the final version. Available on open access from Wiley via the DOI in this recordData Availability Statement:: Data for this study are available at the Dryad Digital Repository: https://doi.org/10.5061/dryad.2v1kr38Resolving stock structure is crucial for fisheries conservation to ensure that the spatial implementation of management is commensurate with that of biological population units. To address this in the economically important European lobster (Homarus gammarus), genetic structure was explored across the species' range using a small panel of single nucleotide polymorphisms (SNPs) previously isolated from restriction-site-associated DNA sequencing; these SNPs were selected to maximize differentiation at a range of both broad and fine scales. After quality control and filtering, 1,278 lobsters from 38 sampling sites were genotyped at 79 SNPs. The results revealed a pronounced phylogeographic break between the Atlantic and Mediterranean basins, while structure within the Mediterranean was also apparent, partitioned between lobsters from the central Mediterranean and the Aegean Sea. In addition, a genetic cline across the north-east Atlantic was revealed using both putatively neutral and outlier SNPs, but the precise driver(s) of this clinal pattern—isolation by distance, secondary contact, selection across an environmental gradient, or a combination of these factors—remains undetermined. Putatively neutral markers differentiated lobsters from Oosterschelde, an estuary on the Dutch coast, a finding likely explained by past bottlenecks and limited gene flow with adjacent North Sea populations. Building on the findings of our spatial genetic analysis, we were able to test the accuracy of assigning lobsters at various spatial scales, including to basin of origin (Atlantic or Mediterranean), region of origin and sampling location. The predictive model assembled using 79 SNPs correctly assigned 99.7% of lobsters not used to build the model to their basin of origin, but accuracy decreased to region of origin and again to sampling location. These results are of direct relevance to managers of lobster fisheries and hatcheries, and provide the basis for a genetic tool for tracing the origin of European lobsters in the food supply chain.Natural Environment Research Council (NERC)Natural EnglandUniversity of Exete

High-velocity OH megamasers in IRAS 20100-4156: Evidence for a Supermassive Black Hole

We report the discovery of new, high-velocity narrow-line components of the OH megamaser in IRAS 20100-4156. Results from the Australian Square Kilometre Array Pathfinder (ASKAP)'s Boolardy Engineering Test Array (BETA) and the Australia Telescope Compact Array (ATCA) provide two independent measurements of the OH megamaser spectrum. We found evidence for OH megamaser clumps at $-$409 and $-$562 km/s (blue-shifted) from the systemic velocity of the galaxy, in addition to the lines previously known. The presence of such high velocities in the molecular emission from IRAS 20100$-$4156 could be explained by a ~50 pc molecular ring enclosing an approximately 3.8 billion solar mass black hole. We also discuss two alternatives, i.e. that the narrow-line masers are dynamically coupled to the wind driven by the active galactic nucleus or they are associated with two separate galactic nuclei. The comparison between the BETA and ATCA spectra provides another scientific verification of ASKAP's BETA. Our data, combined with previous measurements of the source enabled us to study the variability of the source over a twenty-six year period. The flux density of the brightest OH maser components has reduced by more than a factor of two between 1988 and 2015, whereas a secondary narrow-line component has more than doubled in the same time. Plans for high-resolution VLBI follow-up of this source are discussed, as are prospects for discovering new OH megamasers during the ASKAP early science program.Comment: Accepted to MNRAS. Seven pages, three figure

The comparative clinical course of pregnant and non-pregnant women hospitalised with influenza A(H1N1)pdm09 infection

Introduction: The Influenza Clinical Information Network (FLU-CIN) was established to gather detailed clinical and epidemiological information about patients with laboratory confirmed A(H1N1)pdm09 infection in UK hospitals. This report focuses on the clinical course and outcomes of infection in pregnancy.Methods: A standardised data extraction form was used to obtain detailed clinical information from hospital case notes and electronic records, for patients with PCR-confirmed A(H1N1)pdm09 infection admitted to 13 sentinel hospitals in five clinical 'hubs' and a further 62 non-sentinel hospitals, between 11th May 2009 and 31st January 2010.Outcomes were compared for pregnant and non-pregnant women aged 15-44 years, using univariate and multivariable techniques.Results: Of the 395 women aged 15-44 years, 82 (21%) were pregnant; 73 (89%) in the second or third trimester. Pregnant women were significantly less likely to exhibit severe respiratory distress at initial assessment (OR?=?0.49 (95% CI: 0.30-0.82)), require supplemental oxygen on admission (OR?=?0.40 (95% CI: 0.20-0.80)), or have underlying co-morbidities (p-trend <0.001). However, they were equally likely to be admitted to high dependency (Level 2) or intensive care (Level 3) and/or to die, after adjustment for potential confounders (adj. OR?=?0.93 (95% CI: 0.46-1.92). Of 11 pregnant women needing Level 2/3 care, 10 required mechanical ventilation and three died.Conclusions: Since the expected prevalence of pregnancy in the source population was 6%, our data suggest that pregnancy greatly increased the likelihood of hospital admission with A(H1N1)pdm09. Pregnant women were less likely than non-pregnant women to have respiratory distress on admission, but severe outcomes were equally likely in both groups