118 research outputs found
Geology and ore genesis of the porphyry copper deposits in Baguio District, Luzon Island, Philippines (フィリッピン,ルゾン島バギオ地域の地質及び斑岩銅鉱床の研究)
Improvement of data collection and modelling techniques of disaggregate logit models (a case study on work trip mode-choice behavior in metro Manila)
Thesis--University of Tsukuba, D.So.Ec.Pl.(A), no. 611, 1989. 3. 2
Redox-sensitive probes for the measurement of redox chemistries within phagosomes of macrophages and dendritic cells
AbstractThere is currently much interest in factors that affect redox chemistries within phagosomes of macrophages and dendritic cells. In addition to the antimicrobial role of reactive oxygen species generation within phagosomes, accumulating evidence suggests that phagosomal redox chemistries influence other phagosomal functions such as macromolecular degradation and antigen processing. Whilst the redox chemistries within many sub-cellular compartments are being heavily scrutinized with the increasing use of fluorescent probe technologies, there is a paucity of tools to assess redox conditions within phagosomes. Hence the systems that control redox homeostasis in these unique environments remain poorly defined. This review highlights current redox-sensitive probes that can measure oxidative or reductive activity in phagosomes and discusses their suitability and limitations of use. Probes that are easily targeted to the phagosome by using established approaches are emphasized
Patterns, receptors and signals:regulation of phagosome maturation
Recognition of microbial pathogens and dead cells and their phagocytic uptake by specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo fusion and fission events with endosomal and lysosomal compartments, a process called 'phagosome maturation', which leads to the degradation of the phagosomal content. However, many phagocytic cells also act as antigen-presenting cells and must balance degradation and peptide preservation. Emerging evidence indicates that receptor engagement by phagosomal cargo, as well as inflammatory mediators and cellular activation affect many aspects of phagosome maturation. Unsurprisingly, pathogens have developed strategies to hijack this machinery, thereby interfering with host immunity. Here, we highlight progress in this field, summarize findings on the impact of immune signals, and discuss consequences for pathogen elimination
The discourse of the forbidden: the poetics of horror in the contemporary Filipino horror komiks
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