Baseline characteristics of patients in the reduction of events with darbepoetin alfa in heart failure trial (RED-HF)

<p>Aims: This report describes the baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF) which is testing the hypothesis that anaemia correction with darbepoetin alfa will reduce the composite endpoint of death from any cause or hospital admission for worsening heart failure, and improve other outcomes.</p> <p>Methods and results: Key demographic, clinical, and laboratory findings, along with baseline treatment, are reported and compared with those of patients in other recent clinical trials in heart failure. Compared with other recent trials, RED-HF enrolled more elderly [mean age 70 (SD 11.4) years], female (41%), and black (9%) patients. RED-HF patients more often had diabetes (46%) and renal impairment (72% had an estimated glomerular filtration rate <60 mL/min/1.73 m2). Patients in RED-HF had heart failure of longer duration [5.3 (5.4) years], worse NYHA class (35% II, 63% III, and 2% IV), and more signs of congestion. Mean EF was 30% (6.8%). RED-HF patients were well treated at randomization, and pharmacological therapy at baseline was broadly similar to that of other recent trials, taking account of study-specific inclusion/exclusion criteria. Median (interquartile range) haemoglobin at baseline was 112 (106–117) g/L.</p> <p>Conclusion: The anaemic patients enrolled in RED-HF were older, moderately to markedly symptomatic, and had extensive co-morbidity.</p&gt

The CCP4 suite : integrative software for macromolecular crystallography

The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective with a mission to develop, test, distribute and promote software for macromolecular crystallography. The CCP4 suite is a multiplatform collection of programs brought together by familiar execution routines, a set of common libraries and graphical interfaces. The CCP4 suite has experienced several considerable changes since its last reference article, involving new infrastructure, original programs and graphical interfaces. This article, which is intended as a general literature citation for the use of the CCP4 software suite in structure determination, will guide the reader through such transformations, offering a general overview of the new features and outlining future developments. As such, it aims to highlight the individual programs that comprise the suite and to provide the latest references to them for perusal by crystallographers around the world

Security-Related Customer Communications and Training for Public Transportation Providers

TRB\u27s Transit Cooperative Research Program (TCRP) Report 86: Public Transportation Security, Volume 5: Security-Related Customer Communications and Training for Public Transportation Providers is designed to provide improved tools for security-related customer communications and training. This report is in electronic format on CRP-CD-43. The CD contains a 15-minute video on the importance of training for transit emergencies, a PowerPoint overview of the report, the final report in portable document format (pdf), and templates of communication devices. The TCRP Report 86: Public Transportation Security series assembles relevant information into single, concise volumes, each pertaining to a specific security problem and closely related issues. These volumes focus on the concerns that transit agencies are addressing when developing programs in response to the terrorist attacks of September 11, 2001, and the anthrax attacks that followed. Future volumes of the report will be issued as they are completed

Public Transportation Emergency Mobilization and Emergency Operations Guide

TRB\u27s Transit Cooperative Research Program (TCRP) Report 86: Public Transportation Security, Volume 7 -- Public Transportation Emergency Mobilization and Emergency Operations Guide examines activities that may be taken by public transportation agencies working with their local communities to promote the early recognition of emergency events, expedite response to emergency events, establish multi-agency coordination, and ensure that public transportation resources are available to support the response to an emergency event. TCRP Web Only Document 25, Public Transportation Emergency Mobilization Guide: Appendix B—Survey of U. S. Public Transportation Systems includes additional information on the survey used as input on TCRP Report 86. The TCRP Report 86: Public Transportation Security series assembles relevant information into single, concise volumes, each pertaining to a specific security problem and closely related issues. These volumes focus on the concerns that transit agencies are addressing when developing programs in response to the terrorist attacks of September 11, 2001, and the anthrax attacks that followed. Future volumes of the report will be issued as they are completed

Type tells tales

Type Tells Tales focuses on typography that is integral to the message or story it is expressing. This is type that speaks – that is literally the voice of the narrator. And the narrator is the typographer. This can be quite literal, for example when letters come from the mouth of a person or thing, as in a comics balloon. It can be hand lettering, drawn with its own distinctive peculiarities that convey personality and mood. Precedents for contemporary work might be in Apollinaire’s calligram ‘Il pleut’ or Kurt Schwitters’ children’s picture book The Scarecrow, or in Concrete Poetry, Futurist ‘Words in Freedom’ or Dadaist collage. Seeking out examples in the furthest reaches of graphic design, Steven Heller and Gail Anderson uncover work that reveals how type can be used to render a particular voice or multiple conversations, how letters can be used in various shapes and sizes to create a kind of typographic pantomime, and how type can become both content and illustration as in, for example Paul Rand’s ‘ROARRRRR’. Letters take the shape and form of other things, such as people, faces, animals, cars or planes. There are examples of how typographic blocks, paragraphs, sentences and blurbs can be used to guide the eye through dense information

The CCP4 suite: integrative software for macromolecular crystallography

The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective with a mission to develop, test, distribute and promote software for macromolecular crystallography. The CCP4 suite is a multiplatform collection of programs brought together by familiar execution routines, a set of common libraries and graphical interfaces. The CCP4 suite has experienced several considerable changes since its last reference article, involving new infrastructure, original programs and graphical interfaces. This article, which is intended as a general literature citation for the use of the CCP4 software suite in structure determination, will guide the reader through such transformations, offering a general overview of the new features and outlining future developments. As such, it aims to highlight the individual programs that comprise the suite and to provide the latest references to them for perusal by crystallographers around the world.</p

The CCP4 suite: integrative software for macromolecular crystallography.

Funder: European Molecular Biology LaboratoryThe Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective with a mission to develop, test, distribute and promote software for macromolecular crystallography. The CCP4 suite is a multiplatform collection of programs brought together by familiar execution routines, a set of common libraries and graphical interfaces. The CCP4 suite has experienced several considerable changes since its last reference article, involving new infrastructure, original programs and graphical interfaces. This article, which is intended as a general literature citation for the use of the CCP4 software suite in structure determination, will guide the reader through such transformations, offering a general overview of the new features and outlining future developments. As such, it aims to highlight the individual programs that comprise the suite and to provide the latest references to them for perusal by crystallographers around the world