What we have learned : student teachers' views on the quality of mentoring and teaching practice in township schools

Published ArticleIn South Africa a high premium should be placed on the value of effective education and training to achieve an array of economic and social objectives. The development of a strong and functional education system is closely linked with the quality of teaching and learning taking place at schools. In this regard, the nagging shortage of skilled educators underscores the importance of effective training of student teachers to address the shortages and ultimately contribute to the establishment of a competitive and sustainable education system. The present article examines the effectiveness of mentoring and teaching practice experiences of student teachers at a South African university who completed their practical training at township schools. These schools are typically under-resourced, overcrowded and situated in socioeconomically disadvantaged areas. Not only are many of these schools' teachers under-qualified, but the schools also experience acute shortages of teachers in scarce subjects. An empirical study was conducted that targeted all final-year education students who had completed their teaching practice at 34 township schools. The empirical findings provide food for thought as to the success of mentoring in these schools. While 16 aspects of mentoring rendered a positive result ranging from 'positive' to 'strongly positive', seven aspects of mentoring were regarded as 'mildly adequate' and five skills were evaluated as between 'below adequate' to 'inadequate'. Even though the findings of this study cannot be generalised to mentoring at all township schools, some noteworthy trends were identified

Multiple doses of trandolapril do not affect warfarin pharmacodynamics

Objective. The effects of multiple doses of trandolapril (a new angiotensin-converting enzyme inhibitor) on the pharmacodynamics of a single 25 mg dose of warfarin were investigated in 19 men.Design. A double-blind, placebo-controlled cross-over design was used. The study consisted of two periods of 13 days each, during which subjects received either trandolapril 2 mg or placebo once daily according to a randomisation plan. Warfarin was given on day 8 of each of these periods.Setting. The study was carried out at the Hoechst Research Centre for Clinical Pharmacology, Department of Pharmacology, University of the Orange Free State, Bloemfontein.Patients. Nineteen healthy white men aged between 18 and 28 years and weighing between 65 and 98 kg volunteered for the study.Outcome measures. Prothrombin time (PT) and coagulation factors II, VII, IX and X were measured before and sequentially up to 6 days after warfarin administration. Areas under the PT and coagulation factor time curves for warfarin + trandolapril were compared with the corresponding areas for warfarin + placebo. The two treatment combinations were also compared at each measuring time.Results. The point estimate for the ratio of the treatment means of warfarin + trandolapril relative to warfarin + placebo for PT was 97% (90% confidence interval: 90% 103%). The corresponding value for factor VII was 97% (90% confidence interval: 91 % - 102%).Conclusion. The concomitant administration of trandolapril did not affect the pharmacodynamic effects of warfarin

COVID-19 Scenarios: an interactive tool to explore the spread and associated morbidity and mortality of SARS-CoV-2

The ongoing SARS-CoV-2 pandemic has caused large outbreaks around the world and every heavily affected community has experienced a substantial strain on the health care system and a high death toll. Communities therefore have to monitor the incidence of COVID-19 carefully and attempt to project the demand for health care. To enable such projections, we have developed an interactive web application that simulates an age-structured SEIR model with separate compartments for severely and critically ill patients. The tool allows the users to modify most parameters of the model, including age specific assumptions on severity. Infection control and mitigation measures that reduce transmission can be specified, as well as age-group specific isolation. The simulation of the model runs entirely on the client side in the browser; all parameter settings and results of the simulation can be exported for further downstream analysis. The tool is available at covid19-scenarios.org and the source code at github.com/neherlab/covid19_scenarios

An African perspective on the Water-Energy-Food nexus.

There is a need to address resource security and distributional justice in developing countries. People need water, energy, and food to sustain their livelihoods, grow economies, and achieve sustainable development. The interactions between these resource sectors form the crux of water-energy-food (WEF) nexus assessments. In this study, we have utilised the WEF Nexus Index to analyse the WEF nexus of 54 African nations. The results from the analysis were used to illustrate the opportunities and constraints for future development. Generally, African countries are performing sub-optimally in the WEF Nexus Index due to the insecurity of water, energy and/or food. The performance of countries varies with context, highlighting the need for contextual analysis in identifying challenges and potential solutions. Implementation of interventions for achieving WEF security needs to be planned from an integrated perspective to optimise synergies and minimize trade-offs. Implementation of the WEF nexus approach towards simultaneous security of WEF resources has potential to improve the WEF nexus. For example and for many African countries, policies that undergird investments in energy supply projects are needed to unlock available freshwater resources and meet food requirements-energy is shown to be a critical enabler of development. Such projects can be utilised to enhance the ability of farmers to manage water through drought-proofing rainfed agriculture, an increase in irrigation development, or both. WEF nexus-based studies, policies, and projects must be focused on the direct and indirect achievement of SDGs 1, 2, 6, 7, and 13, both in terms of access and availability, to ensure distributional justice, especially in the African context. Such actions, combined with broad public participation, can have a ripple effect on other SDGs such as SDGs 5, 10, and 17, thereby reducing inequalities and building partnerships to attain these aspirational goals. The assessment of Africa's relatively low scores in terms of the WEF Nexus Index does not represent a negative narrative. Instead, it provides an entry point to identifying hotspots and understanding the underlying challenges, through which more detailed analyses can lead to identified solutions and policies. Many African countries are trapped in an environment that could be termed a 'poverty-unemployment-inequality nexus' (due to the interlinkages that exist between these 'wicked' problems). The WEF Nexus Index provides high-level insights into these opportunities

Advanced database mining integrating sequence and structure bioinformatics with microfluidics challenges enzyme engineering

Please click Additional Files below to see the full abstract

The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset

The MOF (males absent on the first)-containing NSL (non-specific lethal) complex binds to a subset of active promoters in Drosophila melanogaster and is thought to contribute to proper gene expression. The determinants that target NSL to specific promoters and the circumstances in which the complex engages in regulating transcription are currently unknown. Here, we show that the NSL complex primarily targets active promoters and in particular housekeeping genes, at which it colocalizes with the chromatin remodeler NURF (nucleosome remodeling factor) and the histone methyltransferase Trithorax. However, only a subset of housekeeping genes associated with NSL are actually activated by it. Our analyses reveal that these NSL-activated promoters are depleted of certain insulator binding proteins and are enriched for the core promoter motif ‘Ohler 5’. Based on these results, it is possible to predict whether the NSL complex is likely to regulate a particular promoter. We conclude that the regulatory capacity of the NSL complex is highly context-dependent. Activation by the NSL complex requires a particular promoter architecture defined by combinations of chromatin regulators and core promoter motifs

Nutrition Strategies for Triathlon

Contemporary sports nutrition guidelines recommend that each athlete develop a personalised, periodised and practical approach to eating that allows him or her to train hard, recover and adapt optimally, stay free of illness and injury and compete at their best at peak races. Competitive triathletes undertake a heavy training programme to prepare for three different sports while undertaking races varying in duration from 20 min to 10 h. The everyday diet should be adequate in energy availability, provide CHO in varying amounts and timing around workouts according to the benefits of training with low or high CHO availability and spread high-quality protein over the day to maximise the adaptive response to each session. Race nutrition requires a targeted and well-practised plan that maintains fuel and hydration goals over the duration of the specific event, according to the opportunities provided by the race and other challenges, such as a hot environment. Supplements and sports foods can make a small contribution to a sports nutrition plan, when medical supplements are used under supervision to prevent/treat nutrient deficiencies (e.g. iron or vitamin D) or when sports foods provide a convenient source of nutrients when it is impractical to eat whole foods. Finally, a few evidence-based performance supplements may contribute to optimal race performance when used according to best practice protocols to suit the triathlete’s goals and individual responsiveness

Reference Intervals in Healthy Adult Ugandan Blood Donors and Their Impact on Conducting International Vaccine Trials

BACKGROUND: Clinical trials are increasingly being conducted internationally. In order to ensure enrollment of healthy participants and proper safety evaluation of vaccine candidates, established reference intervals for clinical tests are required in the target population. METHODOLOGY/PRINCIPAL FINDINGS: We report a reference range study conducted in Ugandan adult blood bank donors establishing reference intervals for hematology and clinical chemistry parameters. Several differences were observed when compared to previously established values from the United States, most notably in neutrophils and eosinophils. CONCLUSIONS/SIGNIFICANCE: In a recently conducted vaccine trial in Uganda, 31 percent (n = 69) of volunteers screened (n = 223) were excluded due to hematologic abnormalities. If local reference ranges had been employed, 83% of those screened out due to these abnormalities could have been included in the study, drastically reducing workload and cost associated with the screening process. In addition, toxicity tables used in vaccine and drug trial safety evaluations may need adjustment as some clinical reference ranges determined in this study overlap with grade 1 and grade 2 adverse events

Occupational health and safety and the National Public Health Institute of South Africa : deliberations from a national consultative meeting

On 11 November 2015, the National Department of Health (NDoH) published the National Public Health Institute of South Africa (NAPHISA) Draft Bill 2015 for public comment. The aim of the Draft Bill is: '[t]o provide for the establishment of the National Public Health Institute of South Africa in order to conduct disease and injury surveillance and to provide specialised public health services, public health interventions, training and research directed towards the major health challenges affecting the population of the Republic.'http://www.samj.org.zaam2016School of Health Systems and Public Health (SHSPH

The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development

Mammalian G9a is a histone H3 Lys-9 (H3–K9) methyltransferase localized in euchromatin and acts as a co-regulator for specific transcription factors. G9a is required for proper development in mammals as g9a(−)/g9a(−) mice show growth retardation and early lethality. Here we describe the cloning, the biochemical and genetical analyses of the Drosophila homolog dG9a. We show that dG9a shares the structural organization of mammalian G9a, and that it is a multi-catalytic histone methyltransferase with specificity not only for lysines 9 and 27 on H3 but also for H4. Surprisingly, it is not the H4–K20 residue that is the target for this methylation. Spatiotemporal expression analyses reveal that dG9a is abundantly expressed in the gonads of both sexes, with no detectable expression in gonadectomized adults. In addition we find a low but clearly observable level of dG9a transcript in developing embryos, larvae and pupae. Genetic and RNAi experiments reveal that dG9a is involved in ecdysone regulatory pathways