184 research outputs found
Calculated vibrational and electronic properties of various sodium thiogermanate glasses
We study the vibrational and electronic properties of (x)NaS-(1-x)GeS
glasses through DFT-based molecular dynamics simulations, at different sodium
concentrations (). We compute the vibrational density of states for
the different samples in order to determine the contribution of the Na ions
in the VDOS. With an in-depth analysis of the eigenvectors we determine the
spatial and atomic localization of the different modes, and in particular in
the zone corresponding to the Boson peak. We also calculate the electronic
density of states as well as the partial EDOS in order to determine the impact
of the introduction of the sodium modifiers on the electronic properties of the
GeS matrix.Comment: 9 pages, 6 figures; to appear in Chemical Physics (typo. corrected
Rheological Changes After Stenting of a Cerebral Aneurysm: A Finite Element Modeling Approach
Hemodynamic changes in intracranial aneurysms after stent placement include the appearance of areas with stagnant flow and low shear rates. We investigated the influence of stent placement on blood flow velocity and wall shear stress of an intracranial aneurysm using a finite element modeling approach. To assess viscosity changes induced by stent placement, the rheology of blood as non-Newtonian fluid was taken into account in this model. A two-dimensional model with a parent artery, a smaller branching artery, and an aneurysm located at the bifurcation, before and after stent placement, was used for simulation. Flow velocity plots and wall shear stress before and after stent placement was calculated over the entire cardiac circle. Values for dynamic viscosity were calculated with a constitutive equation that was based on experimental studies and yielded a viscosity, which decreases as the shear rate increases. Stent placement lowered peak velocities in the main vortex of the aneurysm by a factor of at least 4 compared to peak velocities in the main artery, and it considerably decreased the wall shear stress of the aneurysm. Dynamic viscosity increases after stent placement persisted over a major part of the cardiac cycle, with a factor of up to 10, most pronounced near the dome of the aneurysm. Finite element modeling can offer insight into rheological changes induced by stent treatment of aneurysms and allows visualizing dynamic viscosity changes induced by stent placemen
Magnifying NASA Roman GBTDS exoplanet science with coordinated observations by ESA Euclid
The ESA Euclid mission is scheduled to launch on July 1st 2023. This White
Paper discusses how Euclid observations of the Galactic Bulge Time Domain
Survey (GBTDS) area could dramatically enhance the exoplanet science output of
the Nancy Grace Roman Space Telescope (Roman). An early Euclid pre-imaging
survey of the Roman GBTDS fields, conducted soon after launch, can improve
proper motion determinations for Roman exoplanet microlenses that can yield a
factor of up to improvement in exoplanet mass measurements. An
extended Euclid mission would also enable the possibility of sustained
simultaneous observations of the GBTDS by Euclid and Roman that would achieve
large gains in several areas of Roman exoplanet science, including science that
is impossible to achieve with Roman alone. These include: a comprehensive
demographic survey for free-floating planets that includes precision mass
measurements to establish the true nature of individual candidates; detection,
confirmation and mass measurements of exomoons; direct exoplanet mass
measurements through parallax and finite source size effects for a large sample
of bound exoplanets detected jointly by Euclid and Roman; enhanced
false-positive discrimination for the large samples of transiting planets that
Roman will detect. Our main recommendation to NASA and ESA is to initiate a
Joint Study Group as early as possible that can examine how both missions could
best conduct a coordinated campaign. We also encourage flexibility in the GBTDS
scheduling.Comment: 15 pages. Submission to the NASA Roman Core Community Survey White
Paper Cal
Vibrational signature of broken chemical order in a GeS2 glass: a molecular dynamics simulation
Using density functional molecular dynamics simulations, we analyze the
broken chemical order in a GeS glass and its impact on the dynamical
properties of the glass through the in-depth study of the vibrational
eigenvectors. We find homopolar bonds and the frequencies of the corresponding
modes are in agreement with experimental data. Localized S-S modes and 3-fold
coordinated sulfur atoms are found to be at the origin of specific Raman peaks
whose origin was not previously clear. Through the ring size statistics we
find, during the glass formation, a conversion of 3-membered rings into larger
units but also into 2-membered rings whose vibrational signature is in
agreement with experiments.Comment: 11 pages, 8 figures; to appear in Phys. Rev.
Euclid-Roman joint microlensing survey: early mass measurement, free floating planets and exomoons
Funding: EB gratefully acknowledge support from NASA grant 80NSSC19K0291. The work of DS is funded by a UK Science and Technology Facilities Council (STFC) PhD studentship. EK also acknowledges support from the STFC. EB, JPB and CR’s work was carried out within the framework of the ANR project COLD-WORLDS supported by the French National Agency for Research with the reference ANR-18-CE31-0002. JPB was supported by the University of Tasmania through the UTAS Foundation, ARC grant DP200101909 and the endowed Warren Chair in Astronomy. JR was supported by NASA ROSES grant 12-EUCLID12-0004, the Nancy Grace Roman Telescope, and JPL, which is run by Caltech under a contract for NASA. RP was supported by the Polish National Agency for Academic Exchange via Polish Returns 2019 grant. DM acknowledges support by the European Research Council (ERC) under the European Union’s FP7 Programme, Grant No. 833031.As the Kepler mission has done for hot exoplanets, the ESA Euclid and NASA Roman missions have the potential to create a breakthrough in our understanding of the demographics of cool exoplanets, including unbound, or "free-floating", planets (FFPs). In this study, we demonstrate the complementarity of the two missions and propose two joint-surveys to better constrain the mass and distance of microlensing events. We first demonstrate that an early brief Euclid survey (7 h) of the Roman microlensing fields will allow the measurement of a large fraction of events relative proper motions and lens magnitudes. Then, we study the potential of simultaneous observations by Roman and Euclid to enable the measurement of the microlensing parallax for the shortest microlensing events. Using detailed simulations of the joint detection yield we show that within one year Roman-Euclid observations will be at least an order of magnitude more sensitive than current ground-based measurements. Depending on the exact distribution of FFP, a joint Roman-Euclid campaign should detect around 130 FFP events within a year, including 110 with measured parallax that strongly constrain the FFP mass, and around 30 FFP events with direct mass and distance measurements. The ability of the joint survey to completely break the microlens mass-distance-velocity degeneracy for a significant subset of events provides a unique opportunity to verify unambiguously the FFP hypothesis or else place abundance limits for FFPs between Earth and Jupiter masses that are up to two orders of magnitude stronger than provided by ground-based surveys. Finally, we study the capabilities of the joint survey to enhance the detection and charcterization of exomoons, and found that it could lead to the detection of the first exomoon.PostprintPeer reviewe
A Real-Space Full Multigrid study of the fragmentation of Li11+ clusters
We have studied the fragmentation of Li11+ clusters into the two
experimentally observed products (Li9+,Li2) and (Li10+,Li) The ground state
structures for the two fragmentation channels are found by Molecular Dynamics
Simulated Annealing in the framework of Local Density Functional theory.
Energetics considerations suggest that the fragmentation process is dominated
by non-equilibrium processes. We use a real-space approach to solve the
Kohn-Sham problem, where the Laplacian operator is discretized according to the
Mehrstellen scheme, and take advantage of a Full MultiGrid (FMG) strategy to
accelerate convergence. When applied to isolated clusters we find our FMG
method to be more efficient than state-of-the-art plane wave calculations.Comment: 9 pages + 6 Figures (in gzipped tar file
Occurrence of Anti-Drug Antibodies against Interferon-Beta and Natalizumab in Multiple Sclerosis: A Collaborative Cohort Analysis
Immunogenicity of biopharmaceutical products in multiple sclerosis is a frequent side effect which has a multifactorial etiology. Here we study associations between anti-drug antibody (ADA) occurrence and demographic and clinical factors. Retrospective data from routine ADA test laboratories in Sweden, Denmark, Austria and Germany (Dusseldorf group) and from one research study in Germany (Munich group) were gathered to build a collaborative multi-cohort dataset within the framework of the ABIRISK project. A subset of 5638 interferon-beta (IFN beta)-treated and 3440 natalizumab-treated patients having data on at least the first two years of treatment were eligible for interval-censored time-to-event analysis. In multivariate Cox regression, IFN beta-1a subcutaneous and IFN beta-1b subcutaneous treated patients were at higher risk of ADA occurrence compared to IFN beta-1a intramuscular-treated patients (pooled HR = 6.4, 95% CI 4.9-8.4 and pooled HR = 8.7, 95% CI 6.6-11.4 respectively). Patients older than 50 years at start of IFN beta therapy developed ADA more frequently than adult patients younger than 30 (pooled HR = 1.8, 95% CI 1.4-2.3). Men developed ADA more frequently than women (pooled HR = 1.3, 95% CI 1.1-1.6). Interestingly we observed that in Sweden and Germany, patients who started IFN beta in April were at higher risk of developing ADA (HR = 1.6, 95% CI 1.1-2.4 and HR = 2.4, 95% CI 1.5-3.9 respectively). This result is not confirmed in the other cohorts and warrants further investigations. Concerning natalizumab, patients older than 45 years had a higher ADA rate (pooled HR = 1.4, 95% CI 1.0-1.8) and women developed ADA more frequently than men (pooled HR = 1.4, 95% CI 1.0-2.0). We confirmed previously reported differences in immunogenicity of the different types of IFN beta. Differences in ADA occurrence by sex and age are reported here for the first time. These findings should be further investigated taking into account other exposures and biomarkers
Occurrence of Anti-Drug Antibodies against Interferon-Beta and Natalizumab in Multiple Sclerosis: A Collaborative Cohort Analysis
Immunogenicity of biopharmaceutical products in multiple sclerosis is a frequent side effect which has a multifactorial etiology. Here we study associations between anti-drug antibody (ADA) occurrence and demographic and clinical factors. Retrospective data from routine ADA test laboratories in Sweden, Denmark, Austria and Germany (Dusseldorf group) and from one research study in Germany (Munich group) were gathered to build a collaborative multi-cohort dataset within the framework of the ABIRISK project. A subset of 5638 interferon-beta (IFN beta)-treated and 3440 natalizumab-treated patients having data on at least the first two years of treatment were eligible for interval-censored time-to-event analysis. In multivariate Cox regression, IFN beta-1a subcutaneous and IFN beta-1b subcutaneous treated patients were at higher risk of ADA occurrence compared to IFN beta-1a intramuscular-treated patients (pooled HR = 6.4, 95% CI 4.9-8.4 and pooled HR = 8.7, 95% CI 6.6-11.4 respectively). Patients older than 50 years at start of IFN beta therapy developed ADA more frequently than adult patients younger than 30 (pooled HR = 1.8, 95% CI 1.4-2.3). Men developed ADA more frequently than women (pooled HR = 1.3, 95% CI 1.1-1.6). Interestingly we observed that in Sweden and Germany, patients who started IFN beta in April were at higher risk of developing ADA (HR = 1.6, 95% CI 1.1-2.4 and HR = 2.4, 95% CI 1.5-3.9 respectively). This result is not confirmed in the other cohorts and warrants further investigations. Concerning natalizumab, patients older than 45 years had a higher ADA rate (pooled HR = 1.4, 95% CI 1.0-1.8) and women developed ADA more frequently than men (pooled HR = 1.4, 95% CI 1.0-2.0). We confirmed previously reported differences in immunogenicity of the different types of IFN beta. Differences in ADA occurrence by sex and age are reported here for the first time. These findings should be further investigated taking into account other exposures and biomarkers
Clinical practice of analysis of anti-drug antibodies against interferon beta and natalizumab in multiple sclerosis patients in Europe:A descriptive study of test results
Antibodies against biopharmaceuticals (anti-drug antibodies, ADA) have been a well-integrated part of the clinical care of multiple sclerosis (MS) in several European countries. ADA data generated in Europe during the more than 10 years of ADA monitoring in MS patients treated with interferon beta (IFNβ) and natalizumab have been pooled and characterized through collaboration within a European consortium. The aim of this study was to report on the clinical practice of ADA testing in Europe, considering the number of ADA tests performed and type of ADA assays used, and to determine the frequency of ADA testing against the different drug preparations in different countries. A common database platform (tranSMART) for querying, analyzing and storing retrospective data of MS cohorts was set up to harmonize the data and compare results of ADA tests between different countries. Retrospective data from six countries (Sweden, Austria, Spain, Switzerland, Germany and Denmark) on 20,695 patients and on 42,555 samples were loaded into tranSMART including data points of age, gender, treatment, samples, and ADA results. The previously observed immunogenic difference among the four IFNβ preparations was confirmed in this large dataset. Decreased usage of the more immunogenic preparations IFNβ-1a subcutaneous (s.c.) and IFNβ-1b s.c. in favor of the least immunogenic preparation IFNβ-1a intramuscular (i.m.) was observed. The median time from treatment start to first ADA test correlated with time to first positive test. Shorter times were observed for IFNβ-1b-Extavia s.c. (0.99 and 0.94 years) and natalizumab (0.25 and 0.23 years), which were introduced on the market when ADA testing was already available, as compared to IFNβ-1a i.m. (1.41 and 2.27 years), IFNβ-1b-Betaferon s.c. (2.51 and 1.96 years) and IFNβ-1a s.c. (2.11 and 2.09 years) which were available years before routine testing began. A higher rate of anti-IFNβ ADA was observed in test samples taken from older patients. Testing for ADA varies between different European countries and is highly dependent on the policy within each country. For drugs where routine monitoring of ADA is not in place, there is a risk that some patients remain on treatment for several years despite ADA positivity. For drugs where a strategy of ADA testing is introduced with the release of the drug, there is a reduced risk of having ADA positive patients and thus of less efficient treatment. This indicates that potential savings in health cost might be achieved by routine analysis of ADA
Human Muscle Satellite Cells as Targets of Chikungunya Virus Infection
BACKGROUND: Chikungunya (CHIK) virus is a mosquito-transmitted alphavirus that causes in humans an acute infection characterised by fever, polyarthralgia, head-ache, and myalgia. Since 2005, the emergence of CHIK virus was associated with an unprecedented magnitude outbreak of CHIK disease in the Indian Ocean. Clinically, this outbreak was characterized by invalidating poly-arthralgia, with myalgia being reported in 97.7% of cases. Since the cellular targets of CHIK virus in humans are unknown, we studied the pathogenic events and targets of CHIK infection in skeletal muscle. METHODOLOGY/PRINCIPAL FINDINGS: Immunohistology on muscle biopsies from two CHIK virus-infected patients with myositic syndrome showed that viral antigens were found exclusively inside skeletal muscle progenitor cells (designed as satelllite cells), and not in muscle fibers. To evaluate the ability of CHIK virus to replicate in human satellite cells, we assessed virus infection on primary human muscle cells; viral growth was observed in CHIK virus-infected satellite cells with a cytopathic effect, whereas myotubes were essentially refractory to infection. CONCLUSIONS/SIGNIFICANCE: This report provides new insights into CHIK virus pathogenesis, since it is the first to identify a cellular target of CHIK virus in humans and to report a selective infection of muscle satellite cells by a viral agent in humans
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