The evolution of university-industry linkages-A framework

This qualitative study extends literature on research commercialization by examining the dynamic nature of university-industry linkages (UIL). Thirty in-depth interviews conducted in Australia and Germany/the Netherlands provide evidence of the different phases through which UILs evolve and respective measures of success. Communication, understanding, trust, and people are universal drivers, yet managers must consider the variations in the nature of these factors to ensure successful UILs. This study equips managers involved in technology transfer, innovation, and commercialization with critical insights into developing effective relationships. The proposed conceptual framework also uncovers notable theoretical and managerial implications and offers some key research directions. © 2012 Published by Elsevier B.V. All rights reserved.Carolin Plewa, Nisha Korff, Claire Johnson, Gregory Macpherson, Thomas Baaken, Giselle Camille Rampersa

The effect of exposure to radiofrequency fields on cancer risk in the general and working population: a protocol for a systematic review of human observational studies

BACKGROUND: The World Health Organization (WHO) has an ongoing project to assess potential health effects of exposure to radiofrequency electromagnetic fields (RF-EMF) in the general and working population. Here we present the protocol for a systematic review of the scientific literature on cancer hazards from exposure to RF-EMF in humans, commissioned by the WHO as part of that project. OBJECTIVE: To assess the quality and strength of the evidence provided by human observational studies for a causal association between exposure to RF-EMF and risk of neoplastic diseases. ELIGIBILITY CRITERIA: We will include cohort and case-control studies investigating neoplasia risks in relation to three types of exposure to RF-EMF: near-field, head-localized, exposure from wireless phone use (SR-A); far-field, whole body, environmental exposure from fixed-site transmitters (SR-B); near/far-field occupational exposures from use of handheld transceivers or RF-emitting equipment in the workplace (SR-C). While no restriction on tumour type will be applied, we will focus on selected neoplasms of the central nervous system (brain, meninges, pituitary gland, acoustic nerve) and salivary gland tumours (SR-A); brain tumours and leukaemias (SR-B, SR-C). INFORMATION SOURCES: Eligible studies will be identified through Medline, Embase, and EMF-Portal. RISK-OF-BIAS ASSESSMENT: We will use a tailored version of the OHAT's tool to evaluate the study's internal validity. DATA SYNTHESIS: We will consider separately studies on different tumours, neoplasm-specific risks from different exposure sources, and a given exposure-outcome pair in adults and children. When a quantitative synthesis of findings can be envisaged, the main aims of the meta-analysis will be to assess the strength of association and the shape of the exposure-response relationship; to quantify the degree of heterogeneity across studies; and explore the sources of inconsistency (if any). When a meta-analysis is judged inappropriate, we will perform a narrative synthesis, complemented by a structured tabulation of results and appropriate visual displays. EVIDENCE ASSESSMENT: Confidence in evidence will be assessed in line with the GRADE approach. FUNDING: This project is supported by the World Health Organization. Co-financing was provided by the New Zealand Ministry of Health; the Istituto Superiore di Sanita in its capacity as a WHO Collaborating Centre for Radiation and Health; ARPANSA as a WHO Collaborating Centre for Radiation Protection. REGISTRATION: PROSPERO CRD42021236798

Monitoring Ion Channel Function In Real Time Through Quantum Decoherence

In drug discovery research there is a clear and urgent need for non-invasive detection of cell membrane ion channel operation with wide-field capability. Existing techniques are generally invasive, require specialized nano structures, or are only applicable to certain ion channel species. We show that quantum nanotechnology has enormous potential to provide a novel solution to this problem. The nitrogen-vacancy (NV) centre in nano-diamond is currently of great interest as a novel single atom quantum probe for nanoscale processes. However, until now, beyond the use of diamond nanocrystals as fluorescence markers, nothing was known about the quantum behaviour of a NV probe in the complex room temperature extra-cellular environment. For the first time we explore in detail the quantum dynamics of a NV probe in proximity to the ion channel, lipid bilayer and surrounding aqueous environment. Our theoretical results indicate that real-time detection of ion channel operation at millisecond resolution is possible by directly monitoring the quantum decoherence of the NV probe. With the potential to scan and scale-up to an array-based system this conclusion may have wide ranging implications for nanoscale biology and drug discovery.Comment: 7 pages, 6 figure

Polymer sequencing by molecular machines: A framework for predicting the resolving power of a sliding contact force spectroscopy sequencing method

We evaluate an AFM-based single molecule force spectroscopy method for mapping sequences in otherwise difficult to sequence heteropolymers, including glycosylated proteins and glycans. The sliding contact force spectroscopy (SCFS) method exploits a sliding contact made between a nanopore threaded over a polymer axle and an AFM probe. We find that for sliding α- and β- cyclodextrin nanopores over a wide range of hydrophilic monomers, the free energy of sliding is proportional to the sum of two dimensionless, easily calculable parameters representing the relative partitioning of the monomer inside the nanopore or in the aqueous phase, and the friction arising from sliding the nanopore over the monomer. Using this relationship we calculate sliding energies for nucleic acids, amino acids, glycan and synthetic monomers and predict on the basis of these calculations that SCFS will detect N- and O-glycosylation of proteins and patterns of sidechains in glycans. For these applications, SCFS offers an alternative to sequence mapping by mass spectrometry or newly-emerging nanopore technologies that may be easily implemented using a standard AFM

Label-Free Optical Detection of Biomolecular Translocation through Nanopore Arrays

In recent years, nanopores have emerged as exceptionally promising single-molecule sensors due to their ability to detect biomolecules at subfemtomole levels in a label-free manner. Development of a high-throughput nanopore-based biosensor requires multiplexing of nanopore measurements. Electrical detection, however, poses a challenge, as each nanopore circuit must be electrically independent, which requires complex nanofluidics and embedded electrodes. Here, we present an optical method for simultaneous measurements of the ionic current across an array of solid-state nanopores, requiring no additional fabrication steps. Proof-of-principle experiments are conducted that show simultaneous optical detection and characterization of ssDNA and dsDNA using an array of pores. Through a comparison with electrical measurements, we show that optical measurements are capable of accessing equivalent transmembrane current information

Bilayer-spanning DNA nanopores with voltage-switching between open and closed state.

Membrane-spanning nanopores from folded DNA are a recent example of biomimetic man-made nanostructures that can open up applications in biosensing, drug delivery, and nanofluidics. In this report, we generate a DNA nanopore based on the archetypal six-helix-bundle architecture and systematically characterize it via single-channel current recordings to address several fundamental scientific questions in this emerging field. We establish that the DNA pores exhibit two voltage-dependent conductance states. Low transmembrane voltages favor a stable high-conductance level, which corresponds to an unobstructed DNA pore. The expected inner width of the open channel is confirmed by measuring the conductance change as a function of poly(ethylene glycol) (PEG) size, whereby smaller PEGs are assumed to enter the pore. PEG sizing also clarifies that the main ion-conducting path runs through the membrane-spanning channel lumen as opposed to any proposed gap between the outer pore wall and the lipid bilayer. At higher voltages, the channel shows a main low-conductance state probably caused by electric-field-induced changes of the DNA pore in its conformation or orientation. This voltage-dependent switching between the open and closed states is observed with planar lipid bilayers as well as bilayers mounted on glass nanopipettes. These findings settle a discrepancy between two previously published conductances. By systematically exploring a large space of parameters and answering key questions, our report supports the development of DNA nanopores for nanobiotechnology.The SH lab is supported by the Leverhulme Trust (RPG-170), UCL Chemistry, EPSRC (Institutional Sponsorship Award), the National Physical Laboratory, and Oxford Nanopore Technologies. KG acknowledges funding from the Winton Program of Physics for Sustainability, Gates Cambridge and the Oppenheimer Trust. UFK was supported by an ERC starting grant #261101.This is the final version of the article. It was first published by ACS under the ACS AuthorChoice license at http://dx.doi.org/10.1021/nn5039433 This permits copying and redistribution of the article or any adaptations for non-commercial purposes

Key success factors for research institutions in research commercialization and industry linkages: outcomes of a German/Australian cooperative project

http://www.amazon.com/New-Directions-Technology-Management/dp/0080451152/ref=si3_rdr_bb_produc

Organisational culture differences and market orientation: an exploratory study of barriers to university-industry relationships

Copyright © 2004-2006 Inderscience Enterprises Limited.Despite the growing importance of university–industry relationships (UIR) and the high proportion of such linkages failing, little is known on barriers to the formation and development of these relationships. This exploratory study aims at exploring such barriers. Organisational culture difference (OCD), such as differences in motivation, time orientation and market orientation (MO), were found to negatively effect UIR formation and development. Negative perceptions of universities' MO clearly emerged from the data. Indeed, universities' MO should be considered as a broad concept based on all value creation factors, not just 'business skills'. Finally, internal structures, bureaucracy and academics' individualistic way of working were identified as further factors potentially hindering university–industry relationships. Managerial implications involve recognising the role of individuals, their passion and experience, in overcoming the barriers identified in this study.Carolin Plewa, Pascale Quester, Thomas Baake

Marketing orientation in university-industry linkages

Initially published as a CD-ROM. Has since been made available online.The concept of marketing orientation (MO hereafter) has been extensively studied in a large range of business-to-business and business-to-customer contexts. However, to date, the issue of universities’ market orientation in research-oriented university-industry linkages has been largely ignored. This is surprising, as linkages between universities and industry entities increase in relevance and number in today’s competitive marketplace. Hence, this exploratory study aims to explore the concept of MO as it applies to universities dealing with industries as their clients. Following a brief review of MO literature, a series of 100 telephone and four in-depth interviews were conducted with experienced research clients and ten in-depth interviews with university staff. Negative perceptions of universities’ MO emerged from the data, with 51% of telephone respondents perceiving research institutions as not market oriented, confirmed by comments and in-depth interviews. Discussions of the relevance and scope of universities’ MO led to the finding that universities’ MO should be considered as a broad concept based on all value creation factors, not just ‘business skills’. Finally, internal structures, bureaucracy, the academics’ individualistic way of working and organizational culture differences were identified as factors potentially hindering MO practice in universities

Science marketing: Best practice, research agenda and a conceptual framework

http://www.affiniscape.com/associations/213/files/conferences/2005%20wmc%20program.pd