2,142 research outputs found
Identification of the plague reservoir in an endemic area of Zambia
Yersinia pestis, the bacterial agent of plague, is primarily a parasite of wild rodents that persists in permanent, discrete enzootic foci throughout the world. The disease is transmitted in humans by bites from fleas of wildlife rodent species. Therefore surveillance is the ultimate public health solution through plague detection in domestic dogs, other carnivores and wild rodents. The investigations of die-offs amongst plague-susceptible colonial rodents are also significant to determine the presence of Y. pestis in a susceptible population.This study details the identification of the plague reservoir in a suspected endemic area of Zambia. The study was undertaken through rodent investigation for the presence of Y. pestis. A total of 105 rodents were sampled routinely and during a suspected plague period. On dissection 4 (3.81%, 95% CI: 1.23â10.0) rodents sampled during an outbreak showed signs of spleen enlargement. The blood, liver, lymph nodes and spleen of each rodent were subjected to culture on 6% sheep blood agar and MaCconkey agar. Colonies obtained were identified as Y. pestis by colony morphologic features, biochemical profiles, mouse inoculation assay and polymerase chain reaction (PCR). The PCR primers used targeted the Y. pestis plasminogen activator gene, chromosomal ferric iron uptake regulation gene and the outer membrane protein B gene.The isolates were also subjected to antibiotic sensitivity tests using the disk diffusion method on Mueller-Hinton agar with sensitivity being observed with ampicillin, amoxicillin, chloramphenicol, gentamycin, streptomycin, tetracycline and trimethoprim-sulfamethoxazole. The findings, identifies a natural reservoir of Y. pestis in Zambia providing the public health officials with a definite host for the control strategy.</jats:p
Continuum Mechanical Parameterisation of Cytoplasmic Dynein from Atomistic Simulation
Cytoplasmic dynein is responsible for intra-cellular transport in eukaryotic cells. Using Fluctuating Finite Element Analysis (FFEA), a novel algorithm that represents proteins as continuum viscoelastic solids subject to thermal noise, we are building computational tools to study the mechanics of these molecular machines. Here we present a methodology for obtaining the material parameters required to represent the flexibility of cytoplasmic dynein within FFEA from atomistic molecular dynamics (MD) simulations, and show this continuum representation is sufficient to capture the principal dynamic properties of the motor
Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice
<p>Background: Dietary restriction (DR) extends lifespan and induces beneficial metabolic effects in many animals. What is far less clear is whether animals retain a metabolic memory to previous DR exposure, that is, can early-life DR preserve beneficial metabolic effects later in life even after the resumption of ad libitum (AL) feeding. We examined a range of metabolic parameters (body mass, body composition (lean and fat mass), glucose tolerance, fed blood glucose, fasting plasma insulin and insulin-like growth factor 1 (IGF-1), insulin sensitivity) in male C57BL/6 mice dietary switched from DR to AL (DR-AL) at 11âmonths of age (mid life). The converse switch (AL-DR) was also undertaken at this time. We then compared metabolic parameters of the switched mice to one another and to age-matched mice maintained exclusively on an AL or DR diet from early life (3âmonths of age) at 1âmonth, 6âmonths or 10âmonths post switch.</p>
<p>Results: Male mice dietary switched from AL-DR in mid life adopted the metabolic phenotype of mice exposed to DR from early life, so by the 10-month timepoint the AL-DR mice overlapped significantly with the DR mice in terms of their metabolic phenotype. Those animals switched from DR-AL in mid life showed clear evidence of a glycemic memory, with significantly improved glucose tolerance relative to mice maintained exclusively on AL feeding from early life. This difference in glucose tolerance was still apparent 10âmonths after the dietary switch, despite body mass, fasting insulin levels and insulin sensitivity all being similar to AL mice at this time.</p>
<p>Conclusions: Male C57BL/6 mice retain a long-term glycemic memory of early-life DR, in that glucose tolerance is enhanced in mice switched from DR-AL in mid life, relative to AL mice, even 10âmonths following the dietary switch. These data therefore indicate that the phenotypic benefits of DR are not completely dissipated following a return to AL feeding. The challenge now is to understand the molecular mechanisms underlying these effects, the time course of these effects and whether similar interventions can confer comparable benefits in humans.</p>
Quantum critical lines in holographic phases with (un)broken symmetry
All possible scaling IR asymptotics in homogeneous, translation invariant
holographic phases preserving or breaking a U(1) symmetry in the IR are
classified. Scale invariant geometries where the scalar extremizes its
effective potential are distinguished from hyperscaling violating geometries
where the scalar runs logarithmically. It is shown that the general critical
saddle-point solutions are characterized by three critical exponents (). Both exact solutions as well as leading behaviors are exhibited.
Using them, neutral or charged geometries realizing both fractionalized or
cohesive phases are found. The generic global IR picture emerging is that of
quantum critical lines, separated by quantum critical points which correspond
to the scale invariant solutions with a constant scalar.Comment: v3: 32+29 pages, 2 figures. Matches version published in JHEP.
Important addition of an exponent characterizing the IR scaling of the
electric potentia
Cost-effectiveness of HBV and HCV screening strategies:a systematic review of existing modelling techniques
Introduction:
Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling framework. It is therefore difficult to compare cost-effectiveness results between studies. This systematic review aims to summarise and critically assess existing economic models for HBV and HCV in order to identify the main methodological differences in modelling approaches.
Methods:
A structured search strategy was developed and a systematic review carried out. A critical assessment of the decision-analytic models was carried out according to the guidelines and framework developed for assessment of decision-analytic models in Health Technology Assessment of health care interventions.
Results:
The overall approach to analysing the cost-effectiveness of screening strategies was found to be broadly consistent for HBV and HCV. However, modelling parameters and related structure differed between models, producing different results. More recent publications performed better against a performance matrix, evaluating model components and methodology.
Conclusion:
When assessing screening strategies for HBV and HCV infection, the focus should be on more recent studies, which applied the latest treatment regimes, test methods and had better and more complete data on which to base their models. In addition to parameter selection and associated assumptions, careful consideration of dynamic versus static modelling is recommended. Future research may want to focus on these methodological issues. In addition, the ability to evaluate screening strategies for multiple infectious diseases, (HCV and HIV at the same time) might prove important for decision makers
Light hadron, Charmonium(-like) and Bottomonium(-like) states
Hadron physics represents the study of strongly interacting matter in all its
manifestations and the understanding of its properties and interactions. The
interest on this field has been revitalized by the discovery of new light
hadrons, charmonium- and bottomonium-like states. I review the most recent
experimental results from different experiments.Comment: Presented at Lepton-Photon 2011, Mumbai, India; 21 pages, 18 figures;
add more references; some correctio
Unbalanced Holographic Superconductors and Spintronics
We present a minimal holographic model for s-wave superconductivity with
unbalanced Fermi mixtures, in 2+1 dimensions at strong coupling. The breaking
of a U(1)_A "charge" symmetry is driven by a non-trivial profile for a charged
scalar field in a charged asymptotically AdS_4 black hole. The chemical
potential imbalance is implemented by turning on the temporal component of a
U(1)_B "spin" field under which the scalar field is uncharged. We study the
phase diagram of the model and comment on the eventual (non) occurrence of
LOFF-like inhomogeneous superconducting phases. Moreover, we study "charge" and
"spin" transport, implementing a holographic realization (and a generalization
thereof to superconducting setups) of Mott's two-current model which provides
the theoretical basis of modern spintronics. Finally we comment on possible
string or M-theory embeddings of our model and its higher dimensional
generalizations, within consistent Kaluza-Klein truncations and brane-anti
brane setups.Comment: 45 pages, 15 figures; v2: two paragraphs below eq. (3.1) slightly
modified, figure 5 (left) replaced, references added; v3: typos corrected,
comments added, figure 12 replace
Where the Sidewalk Ends: Jets and Missing Energy Search Strategies for the 7 TeV LHC
This work explores the potential reach of the 7 TeV LHC to new colored states
in the context of simplified models and addresses the issue of which search
regions are necessary to cover an extensive set of event topologies and
kinematic regimes. This article demonstrates that if searches are designed to
focus on specific regions of phase space, then new physics may be missed if it
lies in unexpected corners. Simple multiregion search strategies can be
designed to cover all of kinematic possibilities. A set of benchmark models are
created that cover the qualitatively different signatures and a benchmark
multiregion search strategy is presented that covers these models.Comment: 30 pages, 8 Figures, 3 Tables. Version accepted at JHEP. Minor
changes. Added figur
Dark Radiation and Dark Matter in Large Volume Compactifications
We argue that dark radiation is naturally generated from the decay of the
overall volume modulus in the LARGE volume scenario. We consider both
sequestered and non-sequestered cases, and find that the axionic superpartner
of the modulus is produced by the modulus decay and it can account for the dark
radiation suggested by observations, while the modulus decay through the
Giudice-Masiero term gives the dominant contribution to the total decay rate.
In the sequestered case, the lightest supersymmetric particles produced by the
modulus decay can naturally account for the observed dark matter density. In
the non-sequestered case, on the other hand, the supersymmetric particles are
not produced by the modulus decay, since the soft masses are of order the heavy
gravitino mass. The QCD axion will then be a plausible dark matter candidate.Comment: 27 pages, 4 figures; version 3: version published in JHE
The Cyprinodon variegatus genome reveals gene expression changes underlying differences in skull morphology among closely related species
Genes in durophage intersection set at 15 dpf. This is a comma separated table of the genes in the 15 dpf durophage intersection set. Given are edgeR results for each pairwise comparison. Columns indicating whether a gene is included in the intersection set at a threshold of 1.5 or 2 fold are provided. (CSV 13ĂÂ kb
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