Outbreak of diarrhea in cows from a dairy herd in the southern region of Minas Gerais State: detection of bovine coronavirus in the feces

An outbreak of diarrhea in adult cattle from a dairy herd of Lavras county, MG, was described. From a herd of 10 cows, seven became ill. The diarrhea lasted six to 10 days, being more prolonged, intense, and with blood in lacting cows. Other signs included apathy, reduced appetite and milk production, and serous nasolacrimal discharge. Bovine coronavirus was detected in fecal samples from the five cattle tested by nested-RT-PC

Isolamento de rotavírus de cães assintomáticos no Brasil

Relata-se o isolamento de rotavírus, a partir de material fecal de dois cães assintomáticos, no Brasil. A ocorrência de rotavírus foi pesquisada em amostras fecais de nove cães assintomáticos, provenientes do Centro de Controle de Zoonoses do município de Osasco, SP. Duas das nove amostras analisadas, por eletroforese em gel de poliacrilamida, foram positivas. O isolamento de rotavírus foi realizado em linhagem de células MA-104, com adição de 10,0µg/mL de tripsina ao meio de manutenção, e confirmado pelo eletroferótipo característico de grupo

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), "A way of making Europe".Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations from CN parity of C4A and C4B augmented risk. The protection contributed per copy of C4A and C4B differed by sex. Stronger protection was afforded by C4A in men and by C4B in women. C4 CN correlated well with its gene expression and serum protein levels, and less C4 was detected for both in SSc patients. Conditioned analysis suggests that C4 genetics strongly contributes to the SSc association within the major histocompatibility complex locus and highlights classical alleles and amino acid variants of HLA-DRB1 and HLA-DPB1 as C4-independent signals

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction