Etude du reflux gastro-oesophagien au cours des paresthésies pharyngées

CAEN-BU Médecine pharmacie (141182102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Description de la motricité gastro-duodénale au cours de la nutrition entérale chez l'homme (étude de l'influence des fibres alimentaires)

La nutrition entérale est largement utilisée en pratique clinique chez l'homme. Les fibres alimentaires sont de plus en plus souvent introduites dans cette alimentation et en particulier les fibres solubles en raison de leurs effets bénéfiques sur la muqueuse digestive. Cependant, la motricité digestive haute ainsi que l'influence possible des fibres alimentaires au cours de la nutrition entérale n'est pas connue. L'objectif de ce travail a été de décrire la motricité antroduodénale, les variations du volume antral, le reflux gastro-oesophagien, la motricité de l'estomac proximal et les variations du pH gastrique au cours de la nutrition entérale et d'étudier l'influence des différents types de fibres alimantaires contenues sans cette alimentation. Pour cela, 5 protocoles de recherche ont été réalisés.ROUEN-BU Médecine-Pharmacie (765402102) / SudocSudocFranceF

Two new peptides to improve post-operative gastric ileus in dog

Peptides can influence gastrointestinal motility, and from data obtained earlier in rats, we hypothesized that MTL-RP/Ghrelin, as well as CGRP receptor antagonist 8-37, could improve gastric post-operative ileus in dog. Dogs submitted to laparotomy were perfused with or saline or CGRP 8-37 or MTL-RP/Ghrelin on days 1-4 post-operatively while gastric emptying was estimated by measuring the postprandial increase in plasma acetaminophen ingested with a meal. As expected, in saline-treated animals the gastric emptying function was impaired post-operatively. The total amount of acetaminophen emptied (AUC over 150 min) on post-operative days 1-4 reached respectively 31+/-5%, 65+/-8%, 60+/-8% and 62+/-8% of the normal emptying capacity. CGRP antagonist increased the total emptying of acetaminophen to 52+/-5% on day 1, 95+/-2% on day 2 and 103+/-3% (P<0.05) on day 3. The delayed emptying of acetaminophen seen post-operatively in saline-treated animals could be completely reversed by MTL-RP/Ghrelin (P<0.01) whether it was given at 100 microg/kg on day 2 (102+/-7% of the normal emptying capacity), 4 microg/kg on day 3 (106+/-7%) or 20 microg/kg on day 4 (132+/-8%). As found earlier in rodents, CGRP receptor antagonist 8-37 as well as MTL-RP/Ghrelin are potent prokinetics to improve post-operative gastric ileus in dog

Propriétés turbulentes de la couche limite de surface à partir des données OCARINA

National audienc

Incomplete resection rates of 4- to 20-mm non-pedunculated colorectal polyps when using wide-field cold snare resection with routine submucosal injection

Background and study aims Incomplete resection of 4- to 20-mm colorectal polyps occur frequently (> 10 %), putting patients at risk for post-colonoscopy colorectal cancer. We hypothesized that routine use of wide-field cold snare resection with submucosal injection (CSP-SI) might reduce incomplete resection rates (IRRs). Patients and methods Patients aged 45 to 80 years undergoing elective colonoscopies were enrolled in a prospective clinical study. All 4- to 20-mm non-pedunculated polyps were resected using CSP-SI. Post-polypectomy margin biopsies were obtained to determine IRRs through histopathology assessment. The primary outcome was IRR, defined as remnant polyp tissue found on margin biopsies. Secondary outcomes included technical success and complication rates. Results A total of 429 patients (median age 65 years, 47.1 % female, adenoma detection rate 40 %) with 204 non-pedunculated colorectal polyps 4 to 20 mm removed using CSP-SI were included in the final analysis. CSP-SI was technical successful in 97.5 % (199/204) of cases (5 conversion to hot snare polypectomy). IRR for CSP-SI was 3.8 % (7/183) (95 % confidence interval [CI] 2.7 %-5.5 %). IRR was 1.6 % (2/129), 16 % (4/25), and 3.4 % (1/29) for adenomas, serrated lesions, and hyperplastic polyps respectively. IRR was 2.3 % (2/87), 6.3 % (4/64), 4.0 % (6/151), and 3.1 % (1/32) for polyps 4 to 5 mm, 6 to 9 mm, < 10 mm, and 10 to 20 mm, respectively. There were no CSP-SI-related serious adverse events. Conclusions Use of CSP-SI results in lower IRRs compared to what has previously been reported in the literature for hot or cold snare polypectomy when not using wide-field cold snare resection with submucosal injection. CSP-SI showed an excellent safety and efficacy profile, however comparative studies to CSP without SI are required to confirm these results

Mayotte seismic crisis: building knowledge in near real-time by combining land and ocean-bottom seismometers, first results

International audienceSummary The brutal onset of seismicity offshore Mayotte island North of the Mozambique Channel, Indian Ocean, that occurred in May 2018 caught the population, authorities, and scientific community off guard. Around 20 potentially felt earthquakes were recorded in the first 5 days, up to magnitude Mw 5.9. The scientific community had little pre-existing knowledge of the seismic activity in the region due to poor seismic network coverage. During 2018 and 2019, the MAYOBS/REVOSIMA seismology group was progressively built between four French research institutions to improve instrumentation and data sets to monitor what we know now as an on-going exceptional sub-marine basaltic eruption. After the addition of 3 medium-band stations on Mayotte island and 1 on Grande Glorieuse island in early 2019, the data recovered from the Ocean Bottom Seismometers were regularly processed by the group to improve the location of the earthquakes detected daily by the land network. We first built a new local 1D velocity model and established specific data processing procedures. The local 1.66 low VP/VS ratio we estimated is compatible with a volcanic island context. We manually picked about 125,000 P and S phases on land and sea bottom stations to locate more than 5,000 events between February 2019 and May 2020. The earthquakes outline two separate seismic clusters offshore that we named Proximal and Distal. The Proximal cluster, located 10km offshore Mayotte eastern coastlines, is 20 to 50 km deep and has a cylindrical shape. The Distal cluster start 5 km to the east of the Proximal cluster and extends below Mayotte's new volcanic edifice, from 50 km up to 25 km depth. The two clusters appear seismically separated, however our dataset is insufficient to firmly demonstrate this