Forage Options for Tanzania Southern Highlands: Preliminary Assessment

In adequate quality and quantity, forages curtail animal production in sub-Saharan Africa. As such, the potential of livestock agriculture to contribute to household nutrition and incomes is usually compromised, against an increasing consumption of animal source foods. The growing consumption deserve forage interventions that can address the feeding gap, and contribute to improved livestock production, and subsequently livestock keepers’ prosperity. Using “Targeting Tools”, a web GIS system, we mapped the suitability of a wide array of grass and forage legumes for southern highlands. Using the maps, we selected context-specific varieties and procured available seeds/planting materials for pilot trials. Following farmers’ participatory approach, we established forage trials in three districts namely, Mufindi, Njombe and Rugwe of southern Tanzania highlands comprising of fourteen forage treatments. The test forages included; two Cenchrus purpureus (Syn. Pennisetum purpureum) cultivars, two Urochloa (Syn. Brachiaria) hybrids and Chloris gayana. Where applicable, we intercropped the grasses with three forage legumes- Lablab purpureus, Stylosanthes guianensis, and Desmodium intortum, while Tripsacum andersonii (Syn. Tripsacum laxum), a grass, was planted as a local check. We observed clear differences amongst the three districts and treatments. Dry matter accumulation (t ha−1) in the districts, and across the various forage treatments was in the order Rugwe>Mufindi>Njombe, even when accumulation kg DM day−1 was considered, in the early harvests. Most DM accumulation was by Napier grass intercropped with Lablab purpureus that was closely comparable to Chloris gayana-Desmodium intercrop. Further observations across more cuttings, farmer’ preference rankings and quality analysis are under way to inform reliable conclusions. The results would be applicable elsewhere with similar agricultural context and ecologies

MIGUEL MATEO DALLO Y LANA, MEXICAN BAROQUE COMPOSER: A FORGOTTEN TREASURE OF PUEBLA

Title from PDF of the title page, viewed on March 9, 2015Dissertation advisor: Robert BodeVitaDissertation (D.M.A)--Conservatory of Music and Dance. University of Missouri--Kansas City, 2011Includes bibliographical references (pages 158-159)As research into the Mexican Baroque continues to expand, forgotten composers and their works are garnering deserved attention. Miguel Mateo Dallo y Lana (c. 1650-1705), who served as maestro de capilla [chapel master] at the Puebla Cathedral from 1686 to 1705, belongs to the tradition of polychoral composition inherited from musicians of the Spanish Renaissance. His liturgical settings, specifically Domine ad adjubandum me festina/Dixit Dominus and Beatus Vir, contain traits indicative of the Baroque period as well. These works reveal the Dallo y Lana's compositional techniques, which include homophonic declamation of text intermingled with polyphonic episodic material, layered above basso continuo. He worked in a time just before Mexican composers fully embraced Italian models, placing him at the end of the mostly autonomous Mexican tradition.Abstract -- Acknowledgments - Introduction -- Life of Miguel Matel Dallo y Lana -- Dallo y Lana and his contemporaries -- Dallo y Lana and his compositional techniques -- Conclusion -- Appendix: Performance edition of Domine ad adjubandum me festina/dixit dominus -- Performance edition of Beatus vir -- Performance edition of Beatus vir (transposed down) -- Bibliograph

Notch signaling during human T cell development

Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species. Here, we review our current understanding of how Notch signaling is activated and used during human T cell development. First, we set the stage by describing the developmental steps that make up human T cell development before describing the expression profiles of Notch receptors, ligands, and target genes during this process. To delineate stage-specific roles for Notch signaling during human T cell development, we subsequently try to interpret the functional Notch studies that have been performed in light of these expression profiles and compare this to its suggested role in the mouse

Notch Ankyrin Repeat Domain Variation Influences Leukemogenesis and Myc Transactivation

, cell-based and structural analyses to compare the abilities of activated Notch1-4 to support T cell development, induce T cell acute lymphoblastic leukemia/lymphoma (T-ALL), and maintain T-ALL cell growth and survival., a direct Notch target that has an important role in Notch-associated T-ALL.We conclude that the leukemogenic potentials of Notch receptors vary, and that this functional difference stems in part from divergence among the highly conserved ankyrin repeats, which influence the transactivation of specific target genes involved in leukemogenesis

Identification of critical paralog groups with indispensable roles in the regulation of signaling flow

Extensive cross-talk between signaling pathways is required to integrate the myriad of extracellular signal combinations at the cellular level. Gene duplication events may lead to the emergence of novel functions, leaving groups of similar genes - termed paralogs - in the genome. To distinguish critical paralog groups (CPGs) from other paralogs in human signaling networks, we developed a signaling network-based method using cross-talk annotation and tissue-specific signaling flow analysis. 75 CPGs were found with higher degree, betweenness centrality, closeness, and ‘bowtieness’ when compared to other paralogs or other proteins in the signaling network. CPGs had higher diversity in all these measures, with more varied biological functions and more specific post-transcriptional regulation than non-critical paralog groups (non-CPG). Using TGF-beta, Notch and MAPK pathways as examples, SMAD2/3, NOTCH1/2/3 and MEK3/6-p38 CPGs were found to regulate the signaling flow of their respective pathways. Additionally, CPGs showed a higher mutation rate in both inherited diseases and cancer, and were enriched in drug targets. In conclusion, the results revealed two distinct types of paralog groups in the signaling network: CPGs and non-CPGs. Thus highlighting the importance of CPGs as compared to non-CPGs in drug discovery and disease pathogenesis

Computational Models of the Notch Network Elucidate Mechanisms of Context-dependent Signaling

The Notch signaling pathway controls numerous cell fate decisions during development and adulthood through diverse mechanisms. Thus, whereas it functions as an oscillator during somitogenesis, it can mediate an all-or-none cell fate switch to influence pattern formation in various tissues during development. Furthermore, while in some contexts continuous Notch signaling is required, in others a transient Notch signal is sufficient to influence cell fate decisions. However, the signaling mechanisms that underlie these diverse behaviors in different cellular contexts have not been understood. Notch1 along with two downstream transcription factors hes1 and RBP-Jk forms an intricate network of positive and negative feedback loops, and we have implemented a systems biology approach to computationally study this gene regulation network. Our results indicate that the system exhibits bistability and is capable of switching states at a critical level of Notch signaling initiated by its ligand Delta in a particular range of parameter values. In this mode, transient activation of Delta is also capable of inducing prolonged high expression of Hes1, mimicking the “ON” state depending on the intensity and duration of the signal. Furthermore, this system is highly sensitive to certain model parameters and can transition from functioning as a bistable switch to an oscillator by tuning a single parameter value. This parameter, the transcriptional repression constant of hes1, can thus qualitatively govern the behavior of the signaling network. In addition, we find that the system is able to dampen and reduce the effects of biological noise that arise from stochastic effects in gene expression for systems that respond quickly to Notch signaling