Experimental study on the effect of adaptive flaps on the aerodynamics of an Ahmed body

We perform an experimental study on the turbulent flow around a square-back Ahmed body of height, h, at varying Re=u∞h/ν∈[0.5,1]×105, where u∞ is the free-stream velocity and ν is the incoming flow kinematic viscosity, under different yaw angles β=(0∘,-5∘,-10∘), to analyze the use of rear flexibly hinged parallel plates as a control strategy to reduce the drag in a self-adaptive manner under changing flow conditions. The model implements rear parallel rigid flaps of depth d=0.5h, which are mounted with torsional joints through embedded flexible foils of calibrated thickness. This holding system restricts the motion of the plates to a rotary displacement, θ. The fluid-structure dynamics is characterized by the reduced velocity, defined as U∗=u∞/fnh, where fn is the natural frequency of rotary oscillations of the hinged plates, measured in free-decay tests of flaps. In fact, we have explored the range of reduced velocity, U∗=[0,65], varying u∞ and consequently Re. We perform force and pressure measurements to quantify the variations of the drag and the base pressure coefficients while laser displacement sensors are used to obtain the angular flaps motion. Results show that the hinged plates decrease the drag coefficient of the original body by nearly 4.4% for flow conditions aligned with the body axis. Under cross-flow conditions, their efficiency is even larger, attaining relative reductions drag of nearly 9.1% at β=-10∘ (13.5% in comparison with a body with fixed rigid plates of the same depth). Such variations are shown to be associated with a passive reconfiguration process of rear flaps. Additionally, hinged flaps are shown to interact with the reflectional-symmetry-breaking (RSB) modes, typically present in the wake of three-dimensional bodies. At aligned conditions, the interaction with the RSB modes is characterized by two regimes, in such a way that the hinged flaps manage to partially stabilize the RSB modes, and consequently to inhibit the bistable behavior at low values of U∗ (in a similar manner to rigid flaps), while at high values of U∗, they respond dynamically to switches between the opposite wake deflections of the RSB modes, deviating themselves accordingly

Unifying local-global type properties in vector optimization.

It is well-known that all local minimum points of a semistrictly quasiconvex real-valued function are global minimum points. Also, any local maximum point of an explicitly quasiconvex real-valued function is a global minimum point, provided that it belongs to the intrinsic core of the function’s domain. The aim of this paper is to show that these “local min - global min” and “local max - global min” type properties can be extended and unified by a single general localglobal extremality principle for certain generalized convex vector-valued functions with respect to two proper subsets of the outcome space. For particular choices of these two sets, we recover and refine several local-global properties known in the literature, concerning unified vector optimization (where optimality is defined with respect to an arbitrary set, not necessarily a convex cone) and, in particular, classical vector/multicriteria optimization.Nicolae Popovici’s research was supported by a grant of the Romanian Ministry of Research and Innovation, CNCS-UEFISCDI, project number PN-III-P4-ID-PCE- 2016-0190, within PNCDI III

Set optimization - a rather short introduction

Recent developments in set optimization are surveyed and extended including various set relations as well as fundamental constructions of a convex analysis for set- and vector-valued functions, and duality for set optimization problems. Extensive sections with bibliographical comments summarize the state of the art. Applications to vector optimization and financial risk measures are discussed along with algorithmic approaches to set optimization problems

Comparative Live-Cell Imaging Analyses of SPA-2, BUD-6 and BNI-1 in Neurospora crassa Reveal Novel Features of the Filamentous Fungal Polarisome

A key multiprotein complex involved in regulating the actin cytoskeleton and secretory machinery required for polarized growth in fungi, is the polarisome. Recognized core constituents in budding yeast are the proteins Spa2, Pea2, Aip3/Bud6, and the key effector Bni1. Multicellular fungi display a more complex polarized morphogenesis than yeasts, suggesting that the filamentous fungal polarisome might fulfill additional functions. In this study, we compared the subcellular organization and dynamics of the putative polarisome components BUD-6 and BNI-1 with those of the bona fide polarisome marker SPA-2 at various developmental stages of Neurospora crassa. All three proteins exhibited a yeast-like polarisome configuration during polarized germ tube growth, cell fusion, septal pore plugging and tip repolarization. However, the localization patterns of all three proteins showed spatiotemporally distinct characteristics during the establishment of new polar axes, septum formation and cytokinesis, and maintained hyphal tip growth. Most notably, in vegetative hyphal tips BUD-6 accumulated as a subapical cloud excluded from the Spitzenkörper (Spk), whereas BNI-1 and SPA-2 partially colocalized with the Spk and the tip apex. Novel roles during septal plugging and cytokinesis, connected to the reinitiation of tip growth upon physical injury and conidial maturation, were identified for BUD-6 and BNI-1, respectively. Phenotypic analyses of gene deletion mutants revealed additional functions for BUD-6 and BNI-1 in cell fusion regulation, and the maintenance of Spk integrity. Considered together, our findings reveal novel polarisome-independent functions of BUD-6 and BNI-1 in Neurospora, but also suggest that all three proteins cooperate at plugged septal pores, and their complex arrangement within the apical dome of mature hypha might represent a novel aspect of filamentous fungal polarisome architecture

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified