922 research outputs found
Inhibitory effect of rhubarb on intestinal α-glucosidase activity in type 1 diabetic rats
Purpose: To investigate the inhibitory effect of rhubarb on α-glucosidase activity in the small intestine of rats with type 1 diabetes.Methods: Type 1 diabetic rat model was established by intraperitoneally injecting 30 male SD rats with 1 % streptozocin (STZ). Rats with fasting blood glucose > 11 mmol/L (24) were used for the study. The rats were randomly divided into three equal groups including control, acarbose and rhubarb groups. Arcabose® (20 mg/kg /day) and rhubarb (100 mg/kg /day) were given by intra-gastric route via insertion of the cannula through the esophagus. Daily fasting blood glucose and daily postprandial glucose levels were assayed for all groups. On day 6, postprandial blood glucose, blood levels of C-peptide and insulin, and intestinal α-glucosidase were also determined.Results: There were no significant differences in levels of C-peptide, insulin and fasting blood glucose between control, Acarbose® and rhubarb groups (p > 0.05). However, α-glucosidase activity at 0, 30, 60 and 120 min in the rhubarb group was 1759.2, 1812.8, 1379.8 and 772.1 U, respectively,) while in the Acarbose® group it was 178.6, 1260.1, 1126.5, 599.2 U, respectively. α-Glucosidase activity in both groups initially showed an increase (p < 0.05), followed by a decline from 60 to 120 min (p ˂ 0.05). After 120 min, α-glucosidase activity in each of the two groups was significantly decreased compared with untreated control (1200 U) (p ˂ 0.05).Conclusion: The inhibitory effect of rhubarb on intestinal α-glucosidase activity of Type 1 diabetic rats is comparable to that of Arcabose®.This suggests that this plant may have clinically potent anti-diabetic properties.Keywords: Type 1 diabetes, α-Glucosidase activity, Acarbose®, Rhubarb, Postprandial glucose leve
Structure Formation, Melting, and the Optical Properties of Gold/DNA Nanocomposites: Effects of Relaxation Time
We present a model for structure formation, melting, and optical properties
of gold/DNA nanocomposites. These composites consist of a collection of gold
nanoparticles (of radius 50 nm or less) which are bound together by links made
up of DNA strands. In our structural model, the nanocomposite forms from a
series of Monte Carlo steps, each involving reaction-limited cluster-cluster
aggregation (RLCA) followed by dehybridization of the DNA links. These links
form with a probability which depends on temperature and particle
radius . The final structure depends on the number of monomers (i. e. gold
nanoparticles) , , and the relaxation time. At low temperature, the
model results in an RLCA cluster. But after a long enough relaxation time, the
nanocomposite reduces to a compact, non-fractal cluster. We calculate the
optical properties of the resulting aggregates using the Discrete Dipole
Approximation. Despite the restructuring, the melting transition (as seen in
the extinction coefficient at wavelength 520 nm) remains sharp, and the melting
temperature increases with increasing as found in our previous
percolation model. However, restructuring increases the corresponding link
fraction at melting to a value well above the percolation threshold. Our
calculated extinction cross section agrees qualitatively with experiments on
gold/DNA composites. It also shows a characteristic ``rebound effect,''
resulting from incomplete relaxation, which has also been seen in some
experiments. We discuss briefly how our results relate to a possible sol-gel
transition in these aggregates.Comment: 12 pages, 10 figure
Stabilization of Hydrodynamic Flows by Small Viscosity Variations
Motivated by the large effect of turbulent drag reduction by minute
concentrations of polymers we study the effects of a weakly space-dependent
viscosity on the stability of hydrodynamic flows. In a recent Letter [Phys.
Rev. Lett. {\bf 87}, 174501, (2001)] we exposed the crucial role played by a
localized region where the energy of fluctuations is produced by interactions
with the mean flow (the "critical layer"). We showed that a layer of weakly
space-dependent viscosity placed near the critical layer can have a very large
stabilizing effect on hydrodynamic fluctuations, retarding significantly the
onset of turbulence. In this paper we extend these observation in two
directions: first we show that the strong stabilization of the primary
instability is also obtained when the viscosity profile is realistic (inferred
from simulations of turbulent flows with a small concentration of polymers).
Second, we analyze the secondary instability (around the time-dependent primary
instability) and find similar strong stabilization. Since the secondary
instability develops around a time-dependent solution and is three-dimensional,
this brings us closer to the turbulent case. We reiterate that the large effect
is {\em not} due to a modified dissipation (as is assumed in some theories of
drag reduction), but due to reduced energy intake from the mean flow to the
fluctuations. We propose that similar physics act in turbulent drag reduction.Comment: 10 pages, 17 figs., REVTeX4, PRE, submitte
Theory of Melting and the Optical Properties of Gold/DNA Nanocomposites
We describe a simple model for the melting and optical properties of a
DNA/gold nanoparticle aggregate. The optical properties at fixed wavelength
change dramatically at the melting transition, which is found to be higher and
narrower in temperature for larger particles, and much sharper than that of an
isolated DNA link. All these features are in agreement with available
experiments. The aggregate is modeled as a cluster of gold nanoparticles on a
periodic lattice connected by DNA bonds, and the extinction coefficient is
computed using the discrete dipole approximation. Melting takes place as an
increasing number of these bonds break with increasing temperature. The melting
temperature corresponds approximately to the bond percolation threshold.Comment: 5 pages, 4 figure. To be published in Phys. Rev.
Magnetic versus crystal field linear dichroism in NiO thin films
We have detected strong dichroism in the Ni x-ray absorption
spectra of monolayer NiO films. The dichroic signal appears to be very similar
to the magnetic linear dichroism observed for thicker antiferromagnetic NiO
films. A detailed experimental and theoretical analysis reveals, however, that
the dichroism is caused by crystal field effects in the monolayer films, which
is a non trivial effect because the high spin Ni ground state is not
split by low symmetry crystal fields. We present a practical experimental
method for identifying the independent magnetic and crystal field contributions
to the linear dichroic signal in spectra of NiO films with arbitrary
thicknesses and lattice strains. Our findings are also directly relevant for
high spin and systems such as LaFeO, FeO,
VO, LaCrO, CrO, and Mn manganate thin films
3D evolution of a filament disappearance event observed by STEREO
A filament disappearance event was observed on 22 May 2008 during our recent
campaign JOP 178. The filament, situated in the southern hemisphere, showed
sinistral chirality consistent with the hemispheric rule. The event was well
observed by several observatories in particular by THEMIS. One day before the
disappearance, H observations showed up and down flows in adjacent
locations along the filament, which suggest plasma motions along twisted flux
rope. THEMIS and GONG observations show shearing photospheric motions leading
to magnetic flux canceling around barbs. STEREO A, B spacecraft with separation
angle 52.4 degrees, showed quite different views of this untwisting flux rope
in He II 304 \AA\ images. Here, we reconstruct the 3D geometry of the filament
during its eruption phase using STEREO EUV He II 304 \AA\ images and find that
the filament was highly inclined to the solar normal. The He II 304 \AA\ movies
show individual threads, which oscillate and rise to an altitude of about 120
Mm with apparent velocities of about 100 km s, during the rapid
evolution phase. Finally, as the flux rope expands into the corona, the
filament disappears by becoming optically thin to undetectable levels. No CME
was detected by STEREO, only a faint CME was recorded by LASCO at the beginning
of the disappearance phase at 02:00 UT, which could be due to partial filament
eruption. Further, STEREO Fe XII 195 \AA\ images showed bright loops beneath
the filament prior to the disappearance phase, suggesting magnetic reconnection
below the flux rope
Electron energy loss and induced photon emission in photonic crystals
The interaction of a fast electron with a photonic crystal is investigated by
solving the Maxwell equations exactly for the external field provided by the
electron in the presence of the crystal. The energy loss is obtained from the
retarding force exerted on the electron by the induced electric field. The
features of the energy loss spectra are shown to be related to the photonic
band structure of the crystal. Two different regimes are discussed: for small
lattice constants relative to the wavelength of the associated electron
excitations , an effective medium theory can be used to describe the
material; however, for the photonic band structure plays an
important role. Special attention is paid to the frequency gap regions in the
latter case.Comment: 12 pages, 7 figure
Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS
Physics of Solar Prominences: II - Magnetic Structure and Dynamics
Observations and models of solar prominences are reviewed. We focus on
non-eruptive prominences, and describe recent progress in four areas of
prominence research: (1) magnetic structure deduced from observations and
models, (2) the dynamics of prominence plasmas (formation and flows), (3)
Magneto-hydrodynamic (MHD) waves in prominences and (4) the formation and
large-scale patterns of the filament channels in which prominences are located.
Finally, several outstanding issues in prominence research are discussed, along
with observations and models required to resolve them.Comment: 75 pages, 31 pictures, review pape
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