Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Inter-loop optimizations in RAJA using loop chains

Typical parallelization approaches such as OpenMP and CUDA provide constructs for parallelizing and blocking for data locality for individual loops. By focusing on each loop separately, these approaches fail to leverage sources of data locality possible due to inter-loop data reuse. The loop chain abstraction provides a framework for reasoning about and applying inter-loop optimizations. In this work, we incorporate the loop chain abstraction into RAJA, a performance portability layer for high-performance computing applications. Using the loop-chain-extended RAJA, or RAJALC, developers can have the RAJA library apply loop transformations like loop fusion and overlapped tiling while maintaining the original structure of their programs. By introducing targeted symbolic evaluation capabilities, we can collect and cache data access information required to verify loop transformations. We evaluate the performance improvement and refactoring costs of our extension. Overall, our results demonstrate 85-98% of the performance improvements of hand-optimized kernels with dramatically fewer code changes. © 2021 Association for Computing Machinery.Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Scalable Critical-Path Based Performance Analysis

Abstract not provide

MGF: A Grid-Enabled MPI Library with a Delegation Mechanism to Improve Collective Operations

Abstract. The success of Grid technologies depends on the ability of libraries and tools to hide the heterogeneous complexity of Grid systems. MPI-based programming libraries can make this environment more accessible to developers with parallel programming skills. In this paper we present MGF, an MPI library which extends the existing MPICH-G2. MGF aims are: to allow parallel MPI applications to be executed on Grids without source code modifications; to give programmers a detailed view of the execution system network topology; to use the most efficient channel available for point-to-point communications and finally, to improve collective operations efficiency introducing a delegation mechanism