90 research outputs found

    Current status of epilepsy in Malaysia and way ahead

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    Epilepsy is the third most common neurological disorder, following stroke and Alzheimer’s disease with the highest frequency of newly identified cases occurring among children and adults. About 50 million people worldwide have epilepsy, and nearly 80% of epilepsy occur in developing countries including Malaysia. In Malaysia, epilepsy is still a highly misunderstood and a number of studies explored the poor understanding of the illness. Epilepsy patients have the serious impact on quality of life. Both individuals and families of the patients have an appalling experience. Another factor is cost of AEDs which is very high. It is a burden for both patients and their families to meet the costs. There is a significant need persists to develop an accessible, cost effective, efficacious and less toxic antiepileptic drugs. Natural products used in traditional herbal medicine can be an important source for the search of novel anti-epileptogenic compounds. A number of plants used in traditional medicine have shown to possess anticonvulsant activity. Malaysia is rich in medicinal plants. Attempts have been made in the past to explore the effectiveness of some medicinal plants for the treatment of epilepsy, but the rationale for selection of plants was not justifiable and hence they failed to get a hit. Some of the Malaysian plants are used by traditional healers in the treatment of epilepsy, but their therapeutic effectiveness is not being scientifically explored. This review focused to enlighten the status of epilepsy and research required for the Malaysian medicinal plants for the treatment of epilepsy.Alina Arulsamy, Bey Hing Goh, Mohd Farooq Shaik

    Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

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    APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for A3B upregulation in cancer are poorly understood. Here we show that a single E2F cis-element mediates repression in normal cells and that expression is activated by its mutational disruption in a reporter construct or the endogenous A3B gene. The same E2F site is required for A3B induction by polyomavirus T antigen indicating a shared molecular mechanism. Proteomic and biochemical experiments demonstrate the binding of wildtype but not mutant E2F promoters by repressive PRC1.6/E2F6 and DREAM/E2F4 complexes. Knockdown and overexpression studies confirm the involvement of these repressive complexes in regulating A3B expression. Altogether, these studies demonstrate that A3B expression is suppressed in normal cells by repressive E2F complexes and that viral or mutational disruption of this regulatory network triggers overexpression in breast cancer and provides fuel for tumor evolution

    Measurement of prompt D0^{0} and D\overline{D}0^{0} meson azimuthal anisotropy and search for strong electric fields in PbPb collisions at root SNN\sqrt{S_{NN}} = 5.02 TeV

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    The strong Coulomb field created in ultrarelativistic heavy ion collisions is expected to produce a rapiditydependent difference (Av2) in the second Fourier coefficient of the azimuthal distribution (elliptic flow, v2) between D0 (uc) and D0 (uc) mesons. Motivated by the search for evidence of this field, the CMS detector at the LHC is used to perform the first measurement of Av2. The rapidity-averaged value is found to be (Av2) = 0.001 ? 0.001 (stat)? 0.003 (syst) in PbPb collisions at ?sNN = 5.02 TeV. In addition, the influence of the collision geometry is explored by measuring the D0 and D0mesons v2 and triangular flow coefficient (v3) as functions of rapidity, transverse momentum (pT), and event centrality (a measure of the overlap of the two Pb nuclei). A clear centrality dependence of prompt D0 meson v2 values is observed, while the v3 is largely independent of centrality. These trends are consistent with expectations of flow driven by the initial-state geometry. ? 2021 The Author. Published by Elsevier B.V. This is an open access article under the CC BY licens

    Measurement of the CP-violating phase ϕs_{s} in the B0^{0}s_{s}→J/ψ φ(1020) →μ⁺μ⁻K⁺K⁻ channel in proton-proton collisions at √s = 13 TeV

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    Observation of electroweak production of Wγ with two jets in proton-proton collisions at √s = 13 TeV

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    A first observation is presented for the electroweak production of a W boson, a photon, and two jets in proton-proton collisions. The W boson decays are selected by requiring one identified electron or muon and an imbalance in transverse momentum. The two jets are required to have a high dijet mass and a large separation in pseudorapidity. The measurement is based on data collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb1^{-1}. The observed (expected) significance for this process is 4.9 (4.6) standard deviations. After combining with previously reported CMS results at 8 TeV, the observed (expected) significance is 5.3 (4.8) standard deviations. The cross section for the electroweak Wγjj_{γjj} production in a restricted fiducial region is measured as 20.4 +/- 4.5 fb and the total cross section for Wγ_{γ} production in association with 2 jets in the same fiducial region is 108 +/- 16 fb. All results are in good agreement with recent theoretical predictions. Constraints are placed on anomalous quartic gauge couplings in terms of dimension-8 effective field theory operators

    The Physics of the B Factories

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    Measurements of production cross sections of polarized same-sign W boson pairs in association with two jets in proton-proton collisions at s=13 TeV

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    The first measurements of production cross sections of polarized same-sign W±W±boson pairs in proton-proton collisions are reported. The measurements are based on a data sample collected with the CMS detector at the LHC at a center-of-mass energy of 13TeV, corresponding to an integrated luminosity of 137fb−1. Events are selected by requiring exactly two same-sign leptons, electrons or muons, moderate missing transverse momentum, and two jets with a large rapidity separation and a large dijet mass to enhance the contribution of same-sign W±W±scattering events. An observed (expected) 95% confidence level upper limit of 1.17 (0.88)fbis set on the production cross section for longitudinally polarized same-sign W±W±boson pairs. The electroweak production of same-sign W±W±boson pairs with at least one of the Wbosons longitudinally polarized is measured with an observed (expected) significance of 2.3 (3.1) standard deviations.SCOAP

    Intelligent enterprises for construction: Bridging the technology and knowledge gAps through innovation and education

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    IFIP International Federation for Information Processing205119-13

    Creating intelligent enterprises in the Singapore construction industry to support a knowledge economy

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    10.1016/j.buildenv.2005.01.021Building and Environment413367-379BUEN

    Construction demand modelling A systematic approach to using economic indicators and a comparative study of alternative forecasting approaches

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    Available from British Library Document Supply Centre-DSC:DX216765 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo
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