1,577 research outputs found
L1CAM Expression is Related to Non-Endometrioid Histology, and Prognostic for Poor Outcome in Endometrioid Endometrial Carcinoma
The majority of endometrial carcinomas are classified as Type I endometrioid endometrial carcinomas (EECs) and have a good prognosis. Type II non-endometrioid endometrial carcinomas (NEECs) have a significant worse outcome. Yet, 20Â % of the EECs are associated with an unexplained poor outcome. The aim of this study was to determine if L1CAM expression, a recently reported biomarker for aggressive tumor behavior in endometrial carcinoma, was associated with clinicopathological features of EECs. A total of 103 patients diagnosed as EEC at the Radboud University Medical Centre, based on the pathology report were selected. L1CAM status of these tumors was determined, and histologic slides were reviewed by two expert pathologists. L1CAM-positivity was observed in 17Â % (18/103). Review of the diagnostic slides revealed that 11 out of these 18 L1CAM-positive tumors (61Â %) contained a serous- or mixed carcinoma component that was not initially mentioned in the pathology report. L1CAM-expression was associated with advanced age, poor tumor grade, and lymphovascular space invasion. A worse five year progression free survival rate was observed for patients with L1CAM-positive tumors (55.6Â % for the L1CAM-positive group, compared to 83.3Â % for the L1CAM-negative group PÂ =Â 0.01). L1CAM expression carries prognostic value for histologically classified EEC and supports the identification of tumors with a NEEC component. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12253-016-0047-8) contains supplementary material, which is available to authorized users
Inclusive Electron Scattering from Nuclei at
The inclusive A(e,e') cross section for was measured on H,
C, Fe, and Au for momentum transfers from 1-7 (GeV/c). The scaling
behavior of the data was examined in the region of transition from y-scaling to
x-scaling. Throughout this transitional region, the data exhibit -scaling,
reminiscent of the Bloom-Gilman duality seen in free nucleon scattering.Comment: 4 pages, RevTeX; 4 figures (postscript in .tar.Z file
Scientific Objectives of Einstein Telescope
The advanced interferometer network will herald a new era in observational astronomy. There is a very strong science case to go beyond the advanced detector network and build detectors that operate in a frequency range from 1Hz to 10kHz, with sensitivity a factor 10 better in amplitude. Such detectors will be able to probe a range of topics in nuclear physics, astronomy, cosmology and fundamental physics, providing insights into many unsolved problems in these areas
Spin-Momentum Correlations in Quasi-Elastic Electron Scattering from Deuterium
We report on a measurement of spin-momentum correlations in quasi-elastic
scattering of longitudinally polarized electrons with an energy of 720 MeV from
vector-polarized deuterium. The spin correlation parameter was
measured for the reaction for missing
momenta up to 350 MeV/ at a four-momentum transfer squared of 0.21
(GeV/c). The data give detailed information about the spin structure of the
deuteron, and are in good agreement with the predictions of microscopic
calculations based on realistic nucleon-nucleon potentials and including
various spin-dependent reaction mechanism effects. The experiment demonstrates
in a most direct manner the effects of the D-state in the deuteron ground-state
wave function and shows the importance of isobar configurations for this
reaction.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Lett. for publicatio
Virgo detector characterization and data quality: tools
Detector characterization and data quality studiesâcollectively referred to as DetChar activities in this articleâare paramount to the scientific exploitation of the joint dataset collected by the LIGO-Virgo-KAGRA global network of ground-based gravitational-wave (GW) detectors. They take place during each phase of the operation of the instruments (upgrade, tuning and optimization, data taking), are required at all steps of the dataflow (from data acquisition to the final list of GW events) and operate at various latencies (from near real-time to vet the public alerts to offline analyses). This work requires a wide set of tools which have been developed over the years to fulfill the requirements of the various DetChar studies: data access and bookkeeping; global monitoring of the instruments and of the different steps of the data processing; studies of the global properties of the noise at the detector outputs; identification and follow-up of noise peculiar features (whether they be transient or continuously present in the data); quick processing of the public alerts. The present article reviews all the tools used by the Virgo DetChar group during the third LIGO-Virgo Observation Run (O3, from April 2019 to March 2020), mainly to analyze the Virgo data acquired at EGO. Concurrently, a companion article focuses on the results achieved by the DetChar group during the O3 run using these tools
Calibration and sensitivity of the Virgo detector during its second science run
The Virgo detector is a kilometer-length interferometer for gravitational
wave detection located near Pisa (Italy). During its second science run (VSR2)
in 2009, six months of data were accumulated with a sensitivity close to its
design. In this paper, the methods used to determine the parameters for
sensitivity estimation and gravitational wave reconstruction are described. The
main quantities to be calibrated are the frequency response of the mirror
actuation and the sensing of the output power. Focus is also put on their
absolute timing. The monitoring of the calibration data as well as the
parameter estimation with independent techniques are discussed to provide an
estimation of the calibration uncertainties. Finally, the estimation of the
Virgo sensitivity in the frequency-domain is described and typical
sensitivities measured during VSR2 are shown.Comment: 30 pages, 23 figures, 1 table. Published in Classical and Quantum
Gravity (CQG), Corrigendum include
Virgo detector characterization and data quality: results from the O3 run
The Advanced Virgo detector has contributed with its data to the rapid growth of the number of detected GW signals in the past few years, alongside the two Advanced LIGO instruments. First during the last month of the Observation Run 2 (O2) in August 2017 (with, most notably, the compact binary mergers GW170814 and GW170817), and then during the full Observation Run 3 (O3): an 11 months data taking period, between April 2019 and March 2020, that led to the addition of 79 events to the catalog of transient GW sources maintained by LIGO, Virgo and now KAGRA. These discoveries and the manifold exploitation of the detected waveforms benefit from an accurate characterization of the quality of the data, such as continuous study and monitoring of the detector noise sources. These activities, collectively named detector characterization and data quality or DetChar, span the whole workflow of the Virgo data, from the instrument front-end hardware to the final analyses. They are described in detail in the following article, with a focus on the results achieved by the Virgo DetChar group during the O3 run. Concurrently, a companion article describes the tools that have been used by the Virgo DetChar group to perform this work
Virgo calibration and reconstruction of the gravitational wave strain during VSR1
Virgo is a kilometer-length interferometer for gravitational waves detection
located near Pisa. Its first science run, VSR1, occured from May to October
2007. The aims of the calibration are to measure the detector sensitivity and
to reconstruct the time series of the gravitational wave strain h(t). The
absolute length calibration is based on an original non-linear reconstruction
of the differential arm length variations in free swinging Michelson
configurations. It uses the laser wavelength as length standard. This method is
used to calibrate the frequency dependent response of the Virgo mirror
actuators and derive the detector in-loop response and sensitivity within ~5%.
The principle of the strain reconstruction is highlighted and the h(t)
systematic errors are estimated. A photon calibrator is used to check the sign
of h(t). The reconstructed h(t) during VSR1 is valid from 10 Hz up to 10 kHz
with systematic errors estimated to 6% in amplitude. The phase error is
estimated to be 70 mrad below 1.9 kHz and 6 micro-seconds above.Comment: 8 pages, 8 figures, proceedings of Amaldi 8 conference, to be
published in Journal of Physics Conference Series (JPCS). Second release:
correct typo
Reconstruction of the gravitational wave signal during the Virgo science runs and independent validation with a photon calibrator
The Virgo detector is a kilometer-scale interferometer for gravitational wave
detection located near Pisa (Italy). About 13 months of data were accumulated
during four science runs (VSR1, VSR2, VSR3 and VSR4) between May 2007 and
September 2011, with increasing sensitivity.
In this paper, the method used to reconstruct, in the range 10 Hz-10 kHz, the
gravitational wave strain time series from the detector signals is
described. The standard consistency checks of the reconstruction are discussed
and used to estimate the systematic uncertainties of the signal as a
function of frequency. Finally, an independent setup, the photon calibrator, is
described and used to validate the reconstructed signal and the
associated uncertainties.
The uncertainties of the time series are estimated to be 8% in
amplitude. The uncertainty of the phase of is 50 mrad at 10 Hz with a
frequency dependence following a delay of 8 s at high frequency. A bias
lower than and depending on the sky direction of the GW is
also present.Comment: 35 pages, 16 figures. Accepted by CQ
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