746 research outputs found
Early diagnosis of cancer: systems approach to support clinicians in primary care
Georgia Black and colleagues argue that rather than focusing on the initial consultation efforts to reduce diagnosis times should look at the wider system
Quantum gravity correction, evolution of scalar field and inflation
We take the first nontrivial coefficient of the Schwinger-DeWitt expansion as
a leading correction to the action of the second-derivative metric-dilaton
gravity. To fix the ambiguities related with an arbitrary choice of the gauge
fixing condition and the parametrization for the quantum field, one has to use
the classical equations of motion. As a result, the only corrections are the
ones to the potential of the scalar field. It turns out that the parameters of
the initial classical action may be chosen in such a way that the potential
satisfies most of the conditions for successful inflation.Comment: 11 pages, 3 figure
New Exactly Solvable Two-Dimensional Quantum Model Not Amenable to Separation of Variables
The supersymmetric intertwining relations with second order supercharges
allow to investigate new two-dimensional model which is not amenable to
standard separation of variables. The corresponding potential being the
two-dimensional generalization of well known one-dimensional P\"oschl-Teller
model is proven to be exactly solvable for arbitrary integer value of parameter
all its bound state energy eigenvalues are found analytically, and the
algorithm for analytical calculation of all wave functions is given. The shape
invariance of the model and its integrability are of essential importance to
obtain these results.Comment: 23 page
The Evolution of Grocery Wholesaling and Grocery Wholesalers in Ireland and Britain since the 1930s
Studies of industry evolution are relatively scarce outside of industries defined by narrow technological bases. Studies of wholesaling are rarer still. These are curious features given that it is probable that service industries behave differently to manufacturing ones and that wholesaling is such a key function of many economies. This paper looks at the evolution of grocery wholesaling and grocery wholesalers in Ireland and Britain since 1930. It focuses on the processes and drivers of the wholesale industry. Similarities and differences between the two countries are discussed. Particular emphasis is placed on the role of government action as a triggering mechanism for change and on the role of trade associations and industry leaders in developing and following through on market and non-market strategies. The pathways of industry evolution identified differ from those seen in manufacturing. They therefore raise a number of issues for the development of understanding and conceptualisation in industry evolution studies
Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice
BACKGROUND:
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide in the VIP/secretin/glucagon peptide superfamily. Two active forms, PACAP1-38 and PACAP1-27, act through G protein-coupled receptors, the PAC1 and VPAC1/2 receptors. Effects of PACAP include potent vasomotor activity. Vasomotor activity and organ-specific vasomotor effects of PACAP-deficient mice have not yet been investigated; thus, the assessment of its physiological importance in vasomotor functions is still missing. We hypothesized that backup mechanisms exist to maintain PACAP pathway activity in PACAP knockout (KO) mice. Thus, we investigated the vasomotor effects of exogenous vasoactive intestinal peptide (VIP) and PACAP polypeptides in PACAP wild-type (WT) and PACAP-deficient (KO) male mice.
METHODS:
Carotid and femoral arteries were isolated from 8- to 12-week-old male WT and PACAP-KO mice. Vasomotor responses were measured with isometric myography.
RESULTS:
In the arteries of WT mice the peptides induced relaxations, which were significantly greater to PACAP1-38 than to PACAP1-27 and VIP. In KO mice, PACAP1-38 did not elicit relaxation, whereas PACAP1-27 and VIP elicited significantly greater relaxation in KO mice than in WT mice. The specific PAC1R and VPAC1R antagonist completely blocked the PACAP-induced relaxations.
CONCLUSION:
Our data suggest that in PACAP deficiency, backup mechanisms maintain arterial relaxations to polypeptides, indicating an important physiological role for the PACAP pathway in the regulation of vascular tone
Comparison of the LUNA 3He(alpha,gamma)7Be activation results with earlier measurements and model calculations
Recently, the LUNA collaboration has carried out a high precision measurement
on the 3He(alpha,gamma)7Be reaction cross section with both activation and
on-line gamma-detection methods at unprecedented low energies. In this paper
the results obtained with the activation method are summarized. The results are
compared with previous activation experiments and the zero energy extrapolated
astrophysical S factor is determined using different theoretical models.Comment: Accepted for publication in Journal of Physics
Ultra-sensitive in-beam gamma-ray spectroscopy for nuclear astrophysics at LUNA
Ultra-sensitive in-beam gamma-ray spectroscopy studies for nuclear
astrophysics are performed at the LUNA (Laboratory for Underground Nuclear
Astrophysics) 400 kV accelerator, deep underground in Italy's Gran Sasso
laboratory. By virtue of a specially constructed passive shield, the laboratory
gamma-ray background for E_\gamma < 3 MeV at LUNA has been reduced to levels
comparable to those experienced in dedicated offline underground gamma-counting
setups. The gamma-ray background induced by an incident alpha-beam has been
studied. The data are used to evaluate the feasibility of sensitive in-beam
experiments at LUNA and, by extension, at similar proposed facilities.Comment: accepted, Eur. Phys. J.
Measurement of 25Mg(p; gamma)26Al resonance strengths via gamma spectrometry
The COMPTEL instrument performed the first mapping of the 1.809 MeV photons
in the Galaxy, triggering considerable interest in determing the sources of
interstellar 26Al. The predicted 26Al is too low compared to the observation,
for a better understanding more accurate rates for the 25Mg(p; gamma)26Al
reaction are required. The 25Mg(p;gamma)26Al reaction has been investigated at
the resonances at Er= 745; 418; 374; 304 keV at Ruhr-Universitat-Bochum using a
Tandem accelerator and a 4piNaI detector. In addition the resonance at Er = 189
keV has been measured deep underground laboratory at Laboratori Nazionali del
Gran Sasso, exploiting the strong suppression of cosmic background. This low
resonance has been studied with the 400 kV LUNA accelerator and a HPGe
detector. The preliminary results of the resonance strengths will be reported.Comment: Accepted for publication in Journal of Physics
Constraining the S factor of 15N(p,g)16O at Astrophysical Energies
The 15N(p,g)16O reaction represents a break out reaction linking the first
and second cycle of the CNO cycles redistributing the carbon and nitrogen
abundances into the oxygen range. The reaction is dominated by two broad
resonances at Ep = 338 keV and 1028 keV and a Direct Capture contribution to
the ground state of 16O. Interference effects between these contributions in
both the low energy region (Ep < 338 keV) and in between the two resonances
(338 <Ep < 1028 keV) can dramatically effect the extrapolation to energies of
astrophysical interest. To facilitate a reliable extrapolation the 15N(p,g)16O
reaction has been remeasured covering the energy range from Ep=1800 keV down to
130 keV. The results have been analyzed in the framework of a multi-level
R-matrix theory and a S(0) value of 39.6 keV b has been found.Comment: 15 pages, 9 figure
Microtiming patterns and interactions with musical properties in Samba music
In this study, we focus on the interaction between microtiming patterns and several musical properties: intensity, meter and spectral characteristics. The data-set of 106 musical audio excerpts is processed by means of an auditory model and then divided into several spectral regions and metric levels. The resulting segments are described in terms of their musical properties, over which patterns of peak positions and their intensities are sought. A clustering algorithm is used to systematize the process of pattern detection. The results confirm previously reported anticipations of the third and fourth semiquavers in a beat. We also argue that these patterns of microtiming deviations interact with different profiles of intensities that change according to the metrical structure and spectral characteristics. In particular, we suggest two new findings: (i) a small delay of microtiming positions at the lower end of the spectrum on the first semiquaver of each beat and (ii) systematic forms of accelerando and ritardando at a microtiming level covering two-beat and four-beat phrases. The results demonstrate the importance of multidimensional interactions with timing aspects of music. However, more research is needed in order to find proper representations for rhythm and microtiming aspects in such contexts
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