Epidemiology and fitness effects of wood mouse herpesvirus in a natural host population

Rodent gammaherpesviruses have become important models for understanding human herpesvirus diseases. In particular, interactions between murid herpesvirus 4 and Mus musculus (a non-natural host species) have been extensively studied under controlled laboratory conditions. However, several fundamental aspects of murine gammaherpesvirus biology are not well understood, including how these viruses are transmitted from host to host, and their impacts on host fitness under natural conditions. Here, we investigate the epidemiology of a gammaherpesvirus in free-living wood mice (Apodemus sylvaticus) and bank voles (Myodes glareolus) in a 2-year longitudinal study. Wood mouse herpesvirus (WMHV) was the only herpesvirus detected and occurred frequently in wood mice and also less commonly in bank voles. Strikingly, WMHV infection probability was highest in reproductively active, heavy male mice. Infection risk also showed a repeatable seasonal pattern, peaking in spring and declining through the summer. We show that this seasonal decline can be at least partly attributed to reduced recapture of WMHV-infected adults. These results suggest that male reproductive behaviours could provide an important natural route of transmission for these viruses. They also suggest that gammaherpesvirus infection may have significant detrimental effects in wild hosts, questioning the view that these viruses have limited impacts in natural, co-evolved host species

Description of Supernova Data in Conformal Cosmology without Cosmological Constant

We consider cosmological consequences of a conformal invariant formulation of Einstein's General Relativity where instead of the scale factor of the spatial metrics in the action functional a massless scalar (dilaton) field occurs which scales all masses including the Planck mass. Instead of the expansion of the universe we get the Hoyle-Narlikar type of mass evolution, where the temperature history of the universe is replaced by the mass history. We show that this conformal invariant cosmological model gives a satisfactory description of the new supernova Ia data for the effective magnitude - redshift relation without a cosmological constant and make a prediction for the high-redshift behavior which deviates from that of standard cosmology for $z>1.7$.Comment: 13 pages, 1 figure, includes discussion of SN1997ff, text revise

Possible Single Resonant Production of the Fourth Generation Charged Leptons at γe\gamma e Colliders

Single resonant productions of the fourth standard model generation charged lepton via anomalous interactions at gamma e colliders based on future linear e^+ e^- colliders with 500 GeV and 1 TeV center of mass energies are studied. Signatures of $\gamma e\to \ell_4\to e\gamma$ and $\gamma e\to \ell_4\to eZ$ anomalous processes followed by the hadronic and leptonic decay of the Z boson and corresponding standard model backgrounds are discussed in details. The lowest necessary luminosities to observe these processes and the achievable values of the anomalous coupling strengths are determined.Comment: 9 pages, 6 figures, 4 table

A Computer-Assisted Uniqueness Proof for a Semilinear Elliptic Boundary Value Problem

A wide variety of articles, starting with the famous paper (Gidas, Ni and Nirenberg in Commun. Math. Phys. 68, 209-243 (1979)) is devoted to the uniqueness question for the semilinear elliptic boundary value problem -{\Delta}u={\lambda}u+u^p in {\Omega}, u>0 in {\Omega}, u=0 on the boundary of {\Omega}, where {\lambda} ranges between 0 and the first Dirichlet Laplacian eigenvalue. So far, this question was settled in the case of {\Omega} being a ball and, for more general domains, in the case {\lambda}=0. In (McKenna et al. in J. Differ. Equ. 247, 2140-2162 (2009)), we proposed a computer-assisted approach to this uniqueness question, which indeed provided a proof in the case {\Omega}=(0,1)x(0,1), and p=2. Due to the high numerical complexity, we were not able in (McKenna et al. in J. Differ. Equ. 247, 2140-2162 (2009)) to treat higher values of p. Here, by a significant reduction of the complexity, we will prove uniqueness for the case p=3

Cysteine proteinases from papaya (Carica papaya) in the treatment of experimental Trichuris suis infection in pigs: two randomized controlled trials

Background: Cysteine proteinases (CPs) from papaya (Carica papaya) possess anthelmintic properties against human soil-transmitted helminths (STH, Ascaris lumbricoides, Trichuris trichiura and hookworm), but there is a lack of supportive and up-to-date efficacy data. We therefore conducted two randomized controlled trials in pigs to assess the efficacy of papaya CPs against experimental infections with T. suis. Methods: First, we assessed efficacy by means of egg (ERR) and adult worm reduction rate (WRR) of a single-oral dose of 450 μmol active CPs (CP450) against low (inoculum of 300 eggs) and high (inoculum of 3,000 eggs) intensity T. suis infections and compared the efficacy with those obtained after a single-oral dose of 400 mg albendazole (ALB). In the second trial, we determined and compared the efficacy of a series of CP doses (45 [CP45], 115 [CP115], 225 [CP225], and 450 [CP450] μmol) against high intensity infections. Results: CP450 was highly efficacious against both levels of infection intensity, resulting in ERR and WRR of more than 97%. For both levels of infection intensity, CP450 was significantly more efficacious compared to ALB by means of WRR (low infection intensity: 99.0% vs. 39.0%; high infection intensity; 97.4% vs. 23.2%). When the efficacy was assessed by ERR, a significant difference was only observed for high intensity infections, CP450 being more efficacious than ALB (98.9% vs. 59.0%). For low infection intensities, there was no significant difference in ERR between CP450 (98.3%) and ALB (64.4%). The efficacy of CPs increased as a function of increasing dose. When determined by ERR, the efficacy ranged from 2.1% for CP45 to 99.2% for CP450. For WRR the results varied from -14.0% to 99.0%, respectively. Pairwise comparison revealed a significant difference in ERR and WRR only between CP45 and CP450, the latter being more efficacious. Conclusions: A single dose of 450 μmol CPs provided greater efficacy against T. suis infections in pigs than a single-oral dose of 400 mg ALB. Although these results highlight the possibility of papaya CPs for controlling human STH, further development is needed in order to obtain and validate an oral formulation for human application

Results from an Einstein@Home Search for Continuous Gravitational Waves from G347.3 at Low Frequencies in LIGO O2 Data

We present results of a search for periodic gravitational wave signals with frequencies between 20 and 400 Hz from the neutron star in the supernova remnant G347.3-0.5 using LIGO O2 public data. The search is deployed on the volunteer computing project Einstein@Home, with thousands of participants donating compute cycles to make this endeavour possible. We find no significant signal candidate and set the most constraining upper limits to date on the amplitude of gravitational wave signals from the target, corresponding to deformations below 10-6 in a large part of the band. At the frequency of best strain sensitivity, near 166 Hz, we set 90% confidence upper limits on the gravitational wave intrinsic amplitude of . Over most of the frequency range our upper limits are a factor of 20 smaller than the indirect age-based upper limit. © 2022. The Author(s). Published by the American Astronomical Society.

Results from an Einstein@Home search for continuous gravitational waves from G347.3 at low frequencies in LIGO O2 data

We present results of a search for periodic gravitational wave signals with frequency between 20 and 400 Hz, from the neutron star in the supernova remnant G347.3-0.5, using LIGO O2 public data. The search is deployed on the volunteer computing project Einstein@Home, with thousands of participants donating compute cycles to make this endevour possible. We find no significant signal candidate and set the most constraining upper limits to date on the amplitude of gravitational wave signals from the target, corresponding to deformations below $10^{-6}$ in a large part of the band. At the frequency of best strain sensitivity, near $166$ Hz, we set 90\%\ confidence upper limits on the gravitational wave intrinsic amplitude of $h_0^{90\%}\approx 7.0\times10^{-26}$. Over most of the frequency range our upper limits are a factor of 20 smaller than the indirect age-based upper limit

Direct Search for Low Mass Dark Matter Particles with CCDs

A direct dark matter search is performed using fully-depleted high-resistivity CCD detectors . Due to their low electronic readout noise (RMS ~ 7 eV) these devices operate with a very low detection threshold of 40 eV, making the search for dark matter particles with low masses (~ 5 GeV) possible. The results of an engineering run performed in a shallow underground site are presented, demonstrating the potential of this technology in the low mass region