A Kernel Method for the Two-sample Problem

We propose a framework for analyzing and comparing distributions, allowing us to design statistical tests to determine if two samples are drawn from different distributions. Our test statistic is the largest difference in expectations over functions in the unit ball of a reproducing kernel Hilbert space (RKHS). We present two tests based on large deviation bounds for the test statistic, while a third is based on the asymptotic distribution of this statistic. The test statistic can be computed in quadratic time, although efficient linear time approximations are available. Several classical metrics on distributions are recovered when the function space used to compute the difference in expectations is allowed to be more general (eg.~a Banach space). We apply our two-sample tests to a variety of problems, including attribute matching for databases using the Hungarian marriage method, where they perform strongly. Excellent performance is also obtained when comparing distributions over graphs, for which these are the first such tests

A magnetic reconnection model for explaining the multi-wavelength emission of the microquasars Cyg X-1 and Cyg X-3

Recent studies have indicated that cosmic ray acceleration by a first-order Fermi process in magnetic reconnection current sheets can be efficient enough in the surrounds of compact sources. In this work, we discuss this acceleration mechanism operating in the core region of galactic black hole binaries (or microquasars) and show the conditions under which this can be more efficient than shock acceleration. In addition, we compare the corresponding acceleration rate with the relevant radiative loss rates obtaining the possible energy cut-off of the accelerated particles and also compute the expected spectral energy distribution (SED) for two sources of this class, namely Cygnus X-1 and Cygnus X-3, considering both leptonic and hadronic processes. The derived SEDs are comparable to the observed ones in the low and high energy ranges. Our results suggest that hadronic non-thermal emission due to photo-meson production may produce the very high energy gamma-rays in these microquasars.Comment: 17 pages and 7 figures. Accepted for publication in the Monthly Notices of the Royal Astronomical Society (MNRAS

B + B BARCELONA

Tématem projektu je stavba nového gymnázia v Barceloně, v místě, které je typické svými pravidelnými bloky navrženými architektem Cerdou. Stavbu jsem navrhla s respektem k tvaru parcely. Mým cílem bylo, nevytvořit jen vzdělávací budovu pro studenty, ale také kulturní a společenské centrum pro lidi z okolí. Urbanisticky je parcela koncipovaná jako město samo o sobě, které zve kolemjdoucí k návštěvě. Zůstalo příjemné měřítko pro život.The subjekt of the project is the building of a new secondary school in Barcelona, the place, which is typical with his regular piles designed by architekt Cerda. I projected the building with the respect of the shape of site. My tendency was to not only make a educational building for students, but also the cultural and social centre for local inhabitants. The site is conceived as a small city, which invites passers-by to a visit. The pleasant scale factor stayed on.

Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain

The neural capacity to discriminate between emotions emerges early in development, though little is known about specific factors that contribute to variability in this vital skill during infancy. In adults, DNA methylation of the oxytocin receptor gene (OXTRm) is an epigenetic modification that is variable, predictive of gene expression, and has been linked to autism spectrum disorder and the neural response to social cues. It is unknown whether OXTRm is variable in infants, and whether it is predictive of early social function. Implementing a developmental neuroimaging epigenetics approach in a large sample of infants (N = 98), we examined whether OXTRm is associated with neural responses to emotional expressions. OXTRm was assessed at 5 months of age. At 7 months of age, infants viewed happy, angry, and fearful faces while functional near-infrared spectroscopy was recorded. We observed that OXTRm shows considerable variability among infants. Critically, infants with higher OXTRm show enhanced responses to anger and fear and attenuated responses to happiness in right inferior frontal cortex, a region implicated in emotion processing through action-perception coupling. Findings support models emphasizing oxytocin's role in modulating neural response to emotion and identify OXTRm as an epigenetic mark contributing to early brain function

Stop Co-Annihilation in the Minimal Supersymmetric Standard Model Revisited

We re-examine the stop co-annihilation scenario of the Minimal Supersymmetric Standard Model, wherein a bino-like lightest supersymmetric particle has a thermal relic density set by co-annihilations with a scalar partner of the top quark in the early universe. We concentrate on the case where only the top partner sector is relevant for the cosmology, and other particles are heavy. We discuss the cosmology with focus on low energy parameters and an emphasis on the implications of the measured Higgs boson mass and its properties. We find that the irreducible direct detection signal correlated with this cosmology is generically well below projected experimental sensitivity, and in most cases lies below the neutrino background. A larger, detectable, direct detection rate is possible, but is unrelated to the co-annihilation cosmology. LHC searches for compressed spectra are crucial for probing this scenario

Prepontine non-giant neurons drive flexible escape behavior in zebrafish

Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level. However, how sensory cues are integrated within premotor escape circuits remains poorly understood. Here, we show that in zebrafish, less precipitous threats elicit a delayed escape, characterized by flexible trajectories, which are driven by a cluster of 38 prepontine neurons that are completely separate from the fast escape pathway. Whereas neurons that initiate rapid escapes receive direct auditory input and drive motor neurons, input and output pathways for delayed escapes are indirect, facilitating integration of cross-modal sensory information. These results show that rapid decision-making in the escape system is enabled by parallel pathways for ballistic responses and flexible delayed actions and defines a neuronal substrate for hierarchical choice in the vertebrate nervous system