On the full scale and model scale cavitation comparisons of a Deep-V catamaran research vessel

In pushing for greener ships and more sustainable operations, designers and researchers are being challenged to increase vessel performance whilst reducing environmental impact. One topical, and a somewhat challenging aspect of this pursuit, is the reduction in Underwater Radiated Noise (URN). There are several European Collaborative Research Projects currently underway that aim to outline a framework for noise standards, amongst these projects is the Seventh Framework Project (FP7) “Suppression of Underwater Noise Induced by Cavitation” (SONIC) that has been tasked with concentrating on the URN from propeller cavitation; the main contributor to underwater noise generation. As one of the participants of the SONIC project the Newcastle University was involved in the full-scale trials and model-scale propeller testing campaign. The full-scale trial conducted on board Newcastle University’s catamaran research vessel R/V The Princess Royal involved cavitation observations though the dedicated observation windows above each propeller, Propeller Excited Vibration measurements as well as the off-board URN measurements. The model scale tests were made in The Emerson Cavitation Tunnel using a 1:3.5 scale dummy model of the starboard side demi-hull of the vessel. These tests tried to emulate, as best as possible, the full-scale trials in terms of measurement locations and viewing angles

Single coronary artery incidence in 215,140 patients undergoing coronary angiography

Background: The aim of our study is to determine the incidence of single coronary artery (SCA). SCA is a rarely seen coronary anomaly in which the right coronary artery and the left main coronary artery arise from single aortic sinus. Although SCA has a benign course in most cases and its clinical significance is unknown, in some autopsy studies it was shown to be related to sudden cardiac death. Materials and methods: SCA patients detected among 215,140 coronary angiographies (CAG) performed between 1998 and 2013 in SANKO Hospital were included in our study. The classification of CAG was made according to the two different classifications defined by Smith and Lipton and colleagues. Results: A total number of 215,140 patients who underwent routine CAG were included in the study, and SCA was detected in 67 (0.031%) patients. There were 6 (9%) type R-I, 23 (34%) type R-II, 10 (15%) type R-III, 16 (24%) type L-I and 12 (18%) type L-II patients according to the angiographic classification. Conclusions: SCA is rarely seen during routine cardiac catheterisation and its incidence is 0.014–0.066% in angiographic series. In our study, the incidence was shown to be similar to the previous studies.

Morphometric features of the thyroid gland: a cadaveric study of Turkish people

Background: Although racial and ethnic variations in the morphology of anatomical structures are defined well, the size, shape, and weight of the thyroid gland have not previously been reported in Turkish people. This study provides data about the morphometric features of the thyroid gland, thyroid lobes, and pyramidal lobe, and highlights some anatomical variations in people from the Marmara region in Turkey. Material and methods: The material for the present study consisted of thyroid glands obtained from 75 male and 15 female adult cadavers aged between 18 and 80 years. A dissection was carried out and the thyroid glands were exposed. The glands were weighed and measured according to the various age groups of the patients. Results: A pyramidal lobe was found to be present in 57.8% of the cadavers (52/90). During midline dissection of the neck 2 males out of 90 cadavers, giving an incidence of 2.22%, did not show an isthmus. The mean thyroid weight was 26.11 ± 8.14 g. In males it was 26.93 ± 7.96 g while in females it was 21.93 ± 7.98 g. Conclusions: This is the first reported morphometric study on cadaveric thyroid glands from Turkey and it highlights individual and ethnic/racial variations. In order to perform safe and effective surgery and for the accurate diagnosis of thyroid disorders, knowledge of normal anatomy and the variations of the thyroid gland are essential. (Folia Morphol 2011; 70, 2: 103–108

Dual-Band Transmitter and Receiver with Bowtie-Antenna in 0.13 μm SiGe BiCMOS for Gas Spectroscopy at 222 - 270 GHz

This paper presents a transmitter (TX) and a receiver (RX) with bowtie-antenna and silicon lens for gas spectroscopy at 222-270 GHz, which are fabricated in IHP’s 0.13 μm SiGe BiCMOS technology. The TX and RX use two integrated local oscillators for 222 – 256 GHz and 250 – 270 GHz, which are switched for dual-band operation. Due to its directivity of about 27 dBi, the single integrated bowtie-antenna with silicon lens enables an EIRP of about 25 dBm for the TX, and therefore a considerably higher EIRP for the 2-band TX compared to previously reported systems. The double sideband noise temperature of the RX is 20,000 K (18.5 dB noise figure) as measured by the Y-factor method. Absorption spectroscopy of gaseous methanol is used as a measure for the performance of the gas spectroscopy system with TX- and RX-modules

The contribution of testing in the fight against COVID-19: Evidence from Italy

Background: In response to the epidemic of coronavirus disease 2019 (COVID-19), a few countries have rolled out widespread testing of the population, while in other countries only people requiring hospital admission are being screened. After an extensive testing strategy during the initial few weeks in the early phase of the epidemic, the Italian Ministry of Health made its testing policy more stringent. In this study we assess the contribution of the testing policy containing the spread of the COVID-19 epidemic in Northern Italy. Methods: The analysis is focused on the evolution of the epidemic and related health intervention in four regions where ∼80% of the national death toll due to COVID-19 has occurred. The assumed under-estimation of asymptomatic cases has led us to make use of the number of deaths due to the epidemic to analyze the effectiveness of testing. The analysis is conducted through an autoregressive time-series approach where we use official data from the Ministry of Health. Results: The results of the analysis confirm a negative relationship between the number of tests carried out and the progression of the epidemic. In particular, results reveal that the tests are particularly effective in breaking the chain of transmission when they are implemented at the early stages of the spread of the virus. Conclusions: A large-scale testing policy is recommended as a critical contribution to effectively contain the epidemic. In addition, it is highly recommended to set up all necessary measures to enable the quick scale-up of testing capacity whenever required

Seroprevalence and risk factors for toxoplasma infection among pregnant women in Aydin province, Turkey

BACKGROUND: The aims of the present study were to determine the prevalence of toxoplasmosis in pregnant women at first trimester of their pregnancy and to follow up the seroconversion for next two trimesters, and to identify the risk factors and possible contamination routes in Aydin province, Turkey. METHOD: The sample size was calculated as 423 on a prevalence of 50%, d=0.05 at a confidence level of 95% with 10% addition. It was a cross-sectional study with multistage sampling. After a questionnaire applied to the pregnant women, anti-Toxoplasma IgG antibodies were studied with ELISA and IFA, values in conflict with DA test, where IgM antibodies were studied with ELISA and for borderline or positive values of IgM avidity test was used. RESULTS: The mean age of 389 (92.9%) of pregnant women in the study was 24.28+/-4.56 years, the seroprevalence of anti-Toxoplasma IgG antibodies for toxoplasmosis was 30.1%. Seroprevalence was increased with age (p=0.001) and with drinking water consumption other than bottled water (p=0.042). No significant relations were observed between anti-Toxoplasma IgG antibodies and education level, being native or migrant, abortion history, consumption of meat, vegetable and milk/milk products, personal or kitchen hygiene habits, cat owning at home of the pregnant women. No IgM antibody was detected. CONCLUSION: One of every three pregnant women in Aydin was at risk of toxoplasmosis at the first trimester of their pregnancy. Increased seroprevalance with age was a predictable result because of increasing time of exposure. Increased seroprevalence with consumption of municipal and uncontrolled water (well/spring water) supplies was similar with latest epidemiological findings

Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes

Here the authors characterize structural variations (SVs) in a cohort of individuals with complex genomic rearrangements, identifying breakpoints by employing short- and long-read genome sequencing and investigate their impact on gene expression and the three-dimensional chromatin architecture. They find breakpoints are enriched in inactive regions and can result in chromatin domain fusions.Structural variants are a common cause of disease and contribute to a large extent to inter-individual variability, but their detection and interpretation remain a challenge. Here, we investigate 11 individuals with complex genomic rearrangements including germline chromothripsis by combining short- and long-read genome sequencing (GS) with Hi-C. Large-scale genomic rearrangements are identified in Hi-C interaction maps, allowing for an independent assessment of breakpoint calls derived from the GS methods, resulting in >300 genomic junctions. Based on a comprehensive breakpoint detection and Hi-C, we achieve a reconstruction of whole rearranged chromosomes. Integrating information on the three-dimensional organization of chromatin, we observe that breakpoints occur more frequently than expected in lamina-associated domains (LADs) and that a majority reshuffle topologically associating domains (TADs). By applying phased RNA-seq, we observe an enrichment of genes showing allelic imbalanced expression (AIG) within 100 kb around the breakpoints. Interestingly, the AIGs hit by a breakpoint (19/22) display both up- and downregulation, thereby suggesting different mechanisms at play, such as gene disruption and rearrangements of regulatory information. However, the majority of interpretable genes located 200 kb around a breakpoint do not show significant expression changes. Thus, there is an overall robustness in the genome towards large-scale chromosome rearrangements

Detail-preserving switching algorithm for the removal of random-valued impulse noise

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. This paper presents a new algorithm for the denoising of images corrupted with random-valued impulse noise (RVIN). It employs a switching approach that identifies the noisy pixels in the first stage and then estimates their intensity values to restore them. Local statistics of the textons in distinct orientations of the sliding window are exploited to identify the corrupted pixels in an iterative manner; using an adaptive threshold range. Textons are formed by using an isometric grid of minimum local distance that preserves the texture and edge pixels of an image, effectively. At the noise filtering stage, fuzzy rules are used to obtain the noise-free pixels from the proposed tri-directional pixels to estimate the intensity values of identified corrupted pixels. The performance of the proposed denoising algorithm is evaluated on a variety of standard gray-scale images under various intensities of RVIN by comparing it with state-of-the-art denoising methods. The proposed denoising algorithm also has robust denoising and restoration power on biomedical images such as, MRI, X-Ray and CT-Scan. The extensive simulation results based on both quantitative measures and visual representations depict the superior performance of the proposed denoising algorithm for various noise intensities