53 research outputs found

    A prospective, multi-center study: Factors related to the management of diabetic foot infections

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    The Turkish Association of Clinical Microbiology and Infectious Diseases, Diabetic Foot Infections Working Group conducted a prospective study to determine the factors affecting the outcomes of diabetic foot infections.A total of 96 patients were enrolled in the study. Microbiological assessment was performed in 86 patients. A total of 115 causative bacteria were isolated from 71 patients. The most frequently isolated bacterial species was Pseudomonas aeruginosa (n0 21, 18.3%). Among cases with bacterial growth, 37 patients (43%) were infected with 38 (33%) antibiotic-resistant bacteria. The mean (±SD) antibiotics cost was 2,220.42 (±994.59) USD in cases infected with resistant bacteria, while it was 1,206.60 (±1,160.6) USD in patients infected with susceptible bacteria (p4.5 cm2 (p00.041, OR02.8); and that related to the failure of the treatment was the growth of resistant bacteria (p00.016, OR05.333). Diabetic foot osteomyelitis is usually a chronic infection and requires surgical therapy. Amputation is the accepted form of treatment for osteomyelitis. Limited limb-saving surgery and prolonged antibiotic therapy directed toward the definitive causative bacteria are most appropriate. This may decrease limb loss through amputations. As a result the infections caused by resistant bacteria may lead to a high cost of antibiotherapy, prolonged hospitalization duration, and failure of the treatment. © Springer-Verlag 2012

    Impact of vaccination on the presence and severity of symptoms in hospitalized patients with an infection of the Omicron variant (B.1.1.529) of the SARS-CoV-2 (subvariant BA.1)

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    International audienceObjectives: The emergence of SARS-CoV-2 variants raised questions about the extent to which vaccines designed in 2020 have remained effective. We aimed to assess whether vaccine status was associated with the severity of Omicron SARS-CoV-2 infection in hospitalized patients. Methods: We conducted an international, multi-centric, retrospective study in 14 centres (Bulgaria, Croatia, France, and Turkey). We collected data on patients hospitalized for ≥24 hours between 1 December 2021 and 3 March 2022 with PCR-confirmed infection at a time of exclusive Omicron circulation and hospitalization related or not related to the infection. Patients who had received prophylaxis by monoclonal antibodies were excluded. Patients were considered fully vaccinated if they had received at least two injections of either mRNA and/or ChAdOx1-S or one injection of Ad26.CoV2-S vaccines. Results: Among 1215 patients (median age, 73.0 years; interquartile range, 57.0–84.0; 51.3% men), 746 (61.4%) were fully vaccinated. In multivariate analysis, being vaccinated was associated with lower 28-day mortality (Odds Ratio [95% Confidence Interval] (OR [95CI]) = 0.50 [0.32–0.77]), intensive care unit admission (OR [95CI] = 0.40 [0.26–0.62]), and oxygen requirement (OR [95CI] = 0.34 [0.25–0.46]), independent of age and comorbidities. When co-analysing these patients with Omicron infection with 948 patients with Delta infection from a study we recently conducted, Omicron infection was associated with lower 28-day mortality (OR [95CI] = 0.53 [0.37–0.76]), intensive care unit admission (OR [95CI] = 0.19 [0.12–0.28]), and oxygen requirements (OR [95CI] = 0.50 [0.38–0.67]), independent of age, comorbidities, and vaccination status. Discussion: Originally designed vaccines have remained effective on the severity of Omicron SARS-CoV-2 infection. Omicron is associated with a lower risk of severe forms, independent of vaccination and patient characteristics

    Repetition or alternation of context influences sequential congruency effect depending on the presence of contingency

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    The sequential congruency effect (SCE) is defined as the decrease in the congruency effect following incongruent trials compared to congruent trials. The effect of context repetition on the SCE was investigated in four experiments. In all the experiments, dynamic visual white noise was used as the contextual feature, and the number of congruent and incongruent trials was equal. In Experiments 1 and 2, by using eight-value Flanker and Stroop tasks, and excluding stimulus- and response-feature repetitions from the analysis, a SCE was observed in both context repetition and alternation conditions. In Experiment 3, using a two-value Flanker task, all trials consisted of stimulus- and response-feature repetitions, and a SCE was only observed in the context repetition condition. In Experiment 4, we used a four-value Flanker task, which enabled half of the trials to be partial/complete repetitions and the other half to be complete alternations. A SCE was observed in both context repetition and alternation conditions irrespective of the stimulus- and response-feature repetitions. This pattern of results suggested that the effects of context repetition on the SCE are subject to a number of factors including stimulus- and response-feature repetitions and contingency biases. When contingency information exists, the presence of stimulus- and response-feature repetitions was no longer effective in yielding effects of context repetition on the SCE. These findings suggest that the usage of information registered in episodic event representations including stimulus-, response- and contextual-features, control parameters and contingency biases results from interactions of a complex pattern of mechanisms, yet to be further explored
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